An allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities

FEBS Journal

Volumn 277, Issue 11, 2010, Pages 2543-2549

  Jiang, Dazhi ^a   Xu, Jiacui ^a   Sheng, Yongjie ^a   Sun, Yanhong ^a   Zhang, Jin ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Activity; Allosteric; DNAzyme; Grafting; Regulation

Indexed keywords

DEOXYRIBONUCLEOTIDE; DNA; DNAZYME; METAL ION; RNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; DNA CLEAVAGE; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME ANALYSIS; IN VITRO STUDY; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA CLEAVAGE;

ALLOSTERIC REGULATION; BASE SEQUENCE; CATALYTIC DOMAIN; DEOXYRIBONUCLEASES; DEOXYRIBONUCLEOTIDES; DNA; DNA, CATALYTIC; GENETIC VARIATION; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RIBONUCLEASE, PANCREATIC; RNA;

EID: 77952705516     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07669.x     Document Type: Article

References (27)

1. Emilsson GM Breaker RR (2002) Deoxyribozymes: new activities and new applications. Cell Mol Life Sci 59, 596 607.
2. Höbartner C Silverman SK (2007) Recent advances in DNA catalysis. Biopolymers 87, 279 292.
3. Wang DY Sen D (2001) A novel mode of regulation of an RNA-cleaving DNAzyme by effectors that bind to both enzyme and substrate. J Mol Biol 310, 723 734.
4. Wang DY, Lai BHY Sen D (2002) A general strategy for effector-mediated control of RNA-cleaving ribozymes and DNA enzymes. J Mol Biol 318, 33 43.
5. Liu Y Sen D (2004) Light-regulated catalysis by an RNA-cleaving deoxyribozyme. J Mol Biol 341, 887 892.
6. 8 thioether-linked adenosine. J Am Chem Soc 126, 12720 12721.
7. Keiper S Vyle JS (2006) Reversible photocontrol of deoxyribozyme- catalyzed RNA cleavage under multiple-turnover conditions. Angew Chem Int Ed Engl 45, 3306 3309.
8. Lusic H, Young DD, Lively MO Deiters A (2007) Photochemical DNA activation. Org Lett 9, 1903 1906.
9. Chiuman W Li Y (2007) Efficient signaling platforms built from a small catalytic DNA and doubly labeled fluorogenic substrates. Nucleic Acids Res 35, 401 405.
10. Chiuman W Li Y (2007) Simple fluorescent sensors engineered with catalytic DNA 'MgZ' based on a non-classic allosteric design. PLoS ONE 11, e1124.
11. 2+ ions in aqueous solution with high sensitivity and selectivity. J Am Chem Soc 129, 9838 9839.
12. Liu J Lu Y (2007) Rational design of 'turn-on' allosteric DNAzyme catalytic beacons for aqueous mercury ions with ultra high sensitivity and selectivity. Angew Chem Int Ed Engl 46, 7587 7590.
13. Hollenstein M, Hipolito C, Lam C, Dietrich D Perrin DM (2008) A highly selective DNAzyme sensor for mercuric ions. Angew Chem Int Ed Engl 47, 4346 4350.
14. Li J Lu Y (2000) A highly sensitive and selective catalytic DNA biosensor for lead ions. J Am Chem Soc 122, 10466 10467.
15. Liu J, Brown AK, Meng X, Cropek DM, Istok JD, Watson DB Lu Y (2007) A catalytic beacon sensor for uranium with parts-pertrillion sensitivity and millionfold selectivity. Proc Natl Acad Sci USA 104, 2056 2061.
16. Chen X, Wang Y, Liu Q, Zhang Z, Fan C He L (2006) Construction of molecular logic gates with a DNA-cleaving deoxyribozyme. Angew Chem Int Ed Engl 45, 1759 1762.
17. Stojanovic MN, Semova S, Kolpashchikov D, Macdonald J, Morgan C Stefanovic D (2005) Deoxyribozyme-based ligase logic gates and their initial circuits. J Am Chem Soc 127, 6914 6915.
18. Lederman H, Macdonald J, Stefanovic D Stojanovic MN (2006) Deoxyribozyme-based three-input logic gates and construction of a molecular full adder. Biochemistry 45, 1194 1199.
19. Macdonald J, Li Y, Sutovic M, Lederman H, Pendri K, Lu W, Andrews BL, Stefanovic D Stojanovic MN (2006) Medium scale integration of molecular logic gates in an automaton. Nano Lett 6, 2598 2603.
20. Bishop JD Klavins E (2007) An improved autonomous DNA nanomotor. Nano Lett 7, 2574 2577.
21. Carmi N, Balkhi SR Breaker RR (1998) Cleaving DNA with DNA. Proc Natl Acad Sci USA 95, 2233 2237.
22. Santoro SW Joyce GF (1997) A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA 94, 4262 4266.
23. Cruz RPG, Withers JB Li Y (2004) Dinucleotide junction cleavage versatility of 8-17 deoxyribozyme. Chem Biol 11, 57 67.
24. Schlosser K, Gu J, Sule L Li Y (2008) Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme. Nucleic Acids Res 36, 1472 1481.
25. Peracchi A, Bonaccio M Clerici M (2005) A mutational analysis of the 8-17 deoxyribozyme core. J Mol Biol 352, 783 794.
26. Curtis EA Bartel DP (2005) New catalytic structures from an existing ribozyme. Nat Struct Mol Biol 12, 994 1000.
27. Schultes EA Bartel DP (2000) One sequence, two ribozymes: implications for the emergence of new ribozyme folds. Science 289, 448 452.