Allogenic platelet gel in the treatment of pressure sores: A pilot study

International Wound Journal

Volumn 7, Issue 3, 2010, Pages 184-190

  Scevola, Silvia ^a   Nicoletti, Giovanni ^a   Brenta, Federica ^a   Isernia, Paola ^b   Maestri, Marcello ^b   Faga, Angela ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b San Matteo Research and Care Institute   (Italy)

Author keywords

Chronic wound; Difficult to heal wound; Growth factors; Platelet gel; Pressure sores; Ulcer

Indexed keywords

BIOMATERIAL; PLATELET GEL; UNCLASSIFIED DRUG; GEL; PLATELET DERIVED GROWTH FACTOR;

ALLOGRAFT; ARTICLE; CHRONIC WOUND; CLINICAL ARTICLE; CLINICAL PRACTICE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECUBITUS; FEMALE; GRANULATION TISSUE; HUMAN; ITALY; MALE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD INJURY; WOUND DRESSING; WOUND HEALING; ALLOTRANSPLANTATION; ANALYSIS OF VARIANCE; CHRONIC DISEASE; CLASSIFICATION; COMPLICATION; DRUG EFFECTS; GEL; INTRADERMAL DRUG ADMINISTRATION; NONPARAMETRIC TEST; PRESSURE ULCER; PROCEDURES; SEVERITY OF ILLNESS INDEX; SKIN CARE; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ANALYSIS OF VARIANCE; CHRONIC DISEASE; FEMALE; GELS; GRANULATION TISSUE; HUMANS; ITALY; MALE; PILOT PROJECTS; PLATELET-DERIVED GROWTH FACTOR; PRESSURE ULCER; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SKIN CARE; SPINAL CORD INJURIES; STATISTICS, NONPARAMETRIC; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; WOUND HEALING;

EID: 77952701297     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/j.1742-481X.2010.00671.x     Document Type: Article

References (25)

1. Kholar N, Lipton A. Platelets as a source of fibroblast growth promoting activity. Exp Cell Res 1974 87 : 297 301.
2. Kaplan K, Broekman M, Chernoff A, Lesznik GL, Drillings M. Platelet alpha-granule proteins. Blood 1979 53 : 604 618.
3. Rothe M, Falanga V. Growth factors. Arch Dermatol 1989 125 : 1390 1398.
4. Heldin CH, Westermark B. Platelet-derived growth factor: Mechanism of action and possible in vivo function. Cell Regul 1990 1 : 555 566.
5. Pierce GF, Tarpley JE, Tseng J, Bready J, Chang D, Kenney WC, Rudolph R, Robson MC, Vande Berg J, Reid P. Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic non-healing wounds. J Clin Invest 1995 96 : 1336 1350.
6. Hom DB, Linzie B, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg. 2007 9 (3 174 183.
7. Luccarelli E, Beccheroni A, Donati D, Sangiorgi L, Cenacchi A, Del Vento AM, Meotti C, Zambon Bertoja A, Giardino R, Fornasari PM, Mercuri M, Picci P. Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 2003 24 : 3095 3100.
8. Knighton DL, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic non-healing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg 1986 204 : 322 330.
9. Knighton D, Ciresi K, Fiegel VD, Schumerth S, Butler E, Cerra F. Stimulation of repair in chronic, non-healing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet 1990 170 : 56 60.
10. Atri SC, Misra J, Bisht D, Misra K. Use of homologous platelet factors in achieving total healing of recalcitrant skin ulcers. Surgery 1990 108 : 508 512.
11. Senet P, Bon FX, Benbunan M, Bussel A, Traineau R, Calvo F, Dubertret L, Dosquet C. Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. J Vasc Surg 2003 38 : 1342 1348.
12. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, Moroni M, Carabelli A. Platelet gel for healing cutaneous chronic wounds. Transfus Apheresis Sci 2004 30 : 145 151.
13. Mazzucco L, Medici D, Serra M, Panizza R, Rivara G, Orecchia S, Libener R, Cattana E, Levis A, Betta PG, Borzini P. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion 2004 44 : 1013 1018.
14. Robson MC, Phillips LG, Lawrence T, Bishop JB, Youngerman JS, Hayward PG, Broemeling LD, Heggers JP. The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores. Ann Surg 1992 216 : 401 408.
15. Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GF. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet 1992 339 : 23 5.
16. Robson MC, Hill DP, Smith PD, Wang X, Meyer-Siegler K, Ko F, VandeBerg JS, Payne WG, Ochs D, Robson LE. Sequential cytokine therapy for pressure ulcers: clinical and mechanistic response. Ann Surg 2000 231 : 600 611.
17. Mustoe TA, Cutler NR, Allman RM, Goode PS, Deuel TF. A phase II study to evaluate recombinant platelet-derived growth factor-BB in the treatment of stage 3 and 4 pressure ulcers. Arch Surg 1994 129 : 213 219.
18. Eppley B, Woodell J, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implication for wound healing. Plast Reconstr Surg 2004 114 : 1502 1508.
19. Payne WG, Ochs D, Meltzer D, Hill DP, Mannari RJ, Robson LE, Robson MC. Long-term outcome study of growth factor-treated pressure ulcers. Am J Surg 2001 181 : 81 6.
20. Pierce GF, Tarpley JE, Allman RM, Goode PS, Serdar CM, Morris B, Mustoe TA, Berg JV. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB. AJP 1994, 145 : 1399 1410.
21. Landi F, Aloe L, Russo A, Cesari M, Onder G, Bonini S, Carbonin PU, Bernabei R. Topical treatment of pressure ulcers with nerve growth factor. Ann Intern Med 2003 139 : 635 641.
22. Black J, Baharestani M, Cuddigan J, Dorner B, Edsberg L, Langemo D, Posthauer ME, Ratliff C, Taler G. National Pressure Ulcer Advisory Panel's updated pressure ulcer staging system. National Pressure Ulcer Advisory Panel. Dermatol Nurs 2007 19 : 343 349.
23. Stotts NA, Hunt TK. Managing bacterial colonization and infection. Clin Geriatr Med 1997 13 : 565 573.
24. Nedeau AE, Bauer RJ, Gallagher K, Chen H, Liu ZJ, Velazquez OC. A CXCL5 and bFGF-dependent effect of PDGF-B- activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp Cell Res 2008 314 : 2176 2186.
25. Ponte AL, Marais E, Gallav N, Langonné A, Delorme B, Hérault O, Charbord P, Domenech J. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 2007 25 : 1737 1745.