Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation

Journal of Bone and Mineral Research

Volumn 25, Issue 6, 2010, Pages 1246-1256

  Zhao, Lan ^a   Huang, Jian ^a   Guo, Ruolin ^a   Wang, Yi ^a   Chen, Di ^a   Xing, Lianping ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

JunB; MSC; Osteoblasts; Proteasome; Ubiquitination

Indexed keywords

ALKALINE PHOSPHATASE; CYCLIN D1; MESSENGER RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE SMURF1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; BONE MARROW; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN DEGRADATION; UBIQUITINATION;

AMINO ACID MOTIFS; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOGENESIS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-JUN; STROMAL CELLS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77952694691     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.28     Document Type: Article

References (31)

1. Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. 2002;2:389-406. (Pubitemid 34436569)
2. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89:747-754. (Pubitemid 27516177)
3. Komori Y, Yagi H, Nomura S, et al. Targeted disruption of Cbfa 1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89:755-764. (Pubitemid 27516178)
4. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 1999;400:687-693. (Pubitemid 129516185)
5. Ying SX, Hussain ZJ, Zhang YE. Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation. J Biol Chem. 2003;278:39029-39036.
6. Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D. E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem. 2003;278:27939-27944. (Pubitemid 36899988)
7. Wang HR, Zhang Y, Ozdamar B, et al. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science. 2003;302:1775-1779. (Pubitemid 37505743)
8. Kavsak P, Rasmussen RK, Causing CG, et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation. Mol Cell. 2000;6:1365-1375. (Pubitemid 32045929)
9. Murakami G, Watabe T, Takaoka K, Miyazono K, Imamura T. Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol Biol Cell. 2003;14:2809-2817.
10. Xie W, Wang Y, Huang Y, Yang H, Wang J, Hu Z. Toll-like receptor 2 mediates invasion via activating NF-κB in MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun. 2009;379:1027-1032.
11. Narimatsu M, Bose R, Pye M, et al. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009;137:295-307.
12. Ingham RJ, Gish G, Pawson T. The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene. 2004;23:1972-1984.
13. Yamashita M, Ying SX, Zhang GM, et al. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell. 2005;121:101-113.
14. Guo R, Yamashita M, Zhang Q, et al. Ubiquitin Ligase Smurf1 Mediates Tumor Necrosis Factor-induced Systemic Bone Loss by Promoting Proteasomal Degradation of Bone Morphogenetic Signaling Proteins. J Biol Chem. 2008;283:23084-23092.
15. Shen R, Chen M, Wang YJ, et al. Smad6 Interacts with Runx2 and Mediates Smad Ubiquitin Regulatory Factor 1-induced Runx2 Degradation. J Biol Chem. 2006;281:3569-3576.
16. Kaneki H, Guo R, Chen D, et al. Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts. J Biol Chem. 2006;281:4326-4333.
17. Matsuo K, Owens JM, Tonko M, Elliott C, Chambers TJ, Wagner EF. Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Nature Genetics. 2000;24:184-187.
18. Huang J, Zhao L, Yang Q, Xue Y. AhSSK1, a novel SKP1-like protein that interacts with the S-locus F-box protein SLF. Plant J. 2006;46:780-793.
19. Chalaux E, Lopez-Rovira T, Rosa JL, Bartrons R, Ventura F. JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2. J Biol Chem. 1998;273:537-543. (Pubitemid 28042242)
20. Kenner L, Hoebertz A, Beil T, et al. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol. 2004;164:613-623. (Pubitemid 38233322)
21. Hess J, Hartenstein B, Teurich S, Schmidt D, Schorpp-Kistner M, Angel P. Defective endochondral ossification in mice with strongly compromised expression of JunB. J Cell Sci. 2003;116:4587-4596. (Pubitemid 37461613)
22. Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M. Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. Embo J. 2000;19:2056-2068. (Pubitemid 30237581)
23. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001;20:2390-2400.
24. Mukherjee S, Raje N, Schoonmaker JA, et al. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest. 2008;118:491-504.
25. Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF. JunB is essential for mammalian placentation. Embo J. 1999;18:934-948.
26. Sato T, Abe T, Nakamoto N, et al. Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line. Biochem Biophys Res Commun. 2008;377:126-130.
27. Datta NS, Pettway GJ, Chen C, Koh AJ, McCauley LK. Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells. J Bone Miner Res. 2007;22:951-964.
28. Piechaczyk M, Farras R. Regulation and function of JunB in cell proliferation. Biochem Soc Trans. 2008;36:864-867.
29. Gao M, Labuda T, Xia Y, et al. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004;306:271-275. (Pubitemid 39336871)
30. Gallagher E, Gao M, Liu YC, Karin M. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A. 2006;103:1717-1722. (Pubitemid 43228759)
31. Chang L, Kamata H, Solinas G, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006;124:601-613.