Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints

Journal of Controlled Release

Volumn 144, Issue 2, 2010, Pages 242-250

  Schmitt, Frédéric ^a   Lagopoulos, Lucienne ^a,b   Käuper, Peter ^b   Rossi, Nathanaël ^b   Busso, Nathalie ^c   Barge, Jérôme ^d   Wagnières, Georges ^d   Laue, Carsten ^b   Wandrey, Christine ^d   Juillerat Jeanneret, Lucienne ^a  

^a UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

^b Département de l'Appareil Locomoteur ^*

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d EPFL   (Switzerland)

Author keywords

Chitosan; Hyaluronate; Macrophages; Nanogels; Photodynamic therapy; Rheumatoid arthritis

Indexed keywords

ARTICULAR JOINTS; CONTROL-CELL; FUNCTIONALIZED; HYALURONATE; INFLAMMATORY DISORDERS; INTRACELLULAR LOCALIZATION; LONG-TERM RETENTION; LOW MOLECULAR MASS; MOUSE MODELS; MURINE FIBROBLASTS; NANOGELS; PHOTOCYTOTOXICITY; PHOTODYNAMIC TREATMENTS; PROMISING MATERIALS; RHEUMATOID ARTHRITIS; TARGETED DELIVERY; THERAPEUTIC AGENTS; THERAPEUTIC INDEX;

CELL CULTURE; CHITIN; CHITOSAN; DYES; FLUORESCENCE MICROSCOPY; HEALTH; HYDROGELS; LIGANDS; MACROPHAGES; NANOSTRUCTURED MATERIALS; OPTICAL MATERIALS; PATHOLOGY; PHOTOSENSITIZERS; PLASMONS;

PHOTODYNAMIC THERAPY;

CHITOSAN; CHLORIN E6; FLUORESCEIN; HYALURONIC ACID; METHYLPREDNISOLONE ACETATE; NITRIC OXIDE; PHOTOSENSITIZING AGENT; RHODAMINE; SERUM AMYLOID A; TETRAPHENYLCHLORINTETRACARBOXYLIC ACID; TETRAPHENYLPORPHYRINTETRASULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; DRUG UPTAKE; FIBROBLAST; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VIVO STUDY; KNEE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, RHEUMATOID; CELL LINE; CHITOSAN; HUMANS; JOINTS; MACROPHAGES; MICE; NIH 3T3 CELLS; PHOTOSENSITIZING AGENTS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE;

EID: 77952670612     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.02.008     Document Type: Article

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