A DRD2 polymorphism predicts PANSS score variability in schizophrenia patients treated with antipsychotics

Psychiatry Research

Volumn 177, Issue 3, 2010, Pages 367-368

  Voisey, Joanne ^a   Swagell, Christopher D ^a   Hughes, Ian P ^a   Barnes, Mark ^b   Burton, Simon C ^b   van Daal, Angela ^a,c   Morris, C Phillip ^a   Lawford, Bruce R ^a,b   Young, Ross McD ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c BOND UNIVERSITY   (Australia)

Author keywords

Dopamine; Genetics; Genotype; Medication; Psychological disorder

Indexed keywords

CLOZAPINE; DOPAMINE 2 RECEPTOR; NEUROLEPTIC AGENT; OLANZAPINE; RISPERIDONE;

ADULT; ALLELE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; PATIENT COMPLIANCE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SCORING SYSTEM;

ADULT; ANTIPSYCHOTIC AGENTS; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA; YOUNG ADULT;

EID: 77952669568     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2010.02.015     Document Type: Letter

References (5)

1. Amador X.F., Gorman J.M. Psychopathologic domains and insight in schizophrenia. Psychiatric Clinics of North America 1998, 21:27-42.
2. Duan J., Wainwright M.S., Comeron J.M., Saitou N., Sanders A.R., Gelernter J., Gejman P.V. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Human Molecular Genetics 2003, 12:205-216.
3. Hofer A., Kemmler G., Eder U., Honeder M., Hummer M., Fleischhacker W.W. Attitudes toward antipsychotics among outpatient clinic attendees with schizophrenia. Journal of Clinical Psychiatry 2002, 63:49-53.
4. Kapur S., Seeman P. Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. Journal of Psychiatry and Neuroscience 2000, 25:161-166.
5. Lawford B.R., Young R.M., Swagell C.D., Barnes M., Burton S.C., Ward W.K., Heslop K.R., Shadforth S., van Daal A., Morris C.P. The C/C genotype of the C957T polymorphism of the dopamine D2 receptor is associated with schizophrenia. Schizophrenia Research 2005, 73:31-37.