Validation of different replication markers for the detection of beta-cell proliferation in human pancreatic tissue

Regulatory Peptides

Volumn 162, Issue 1-3, 2010, Pages 115-121

  Köhler, Christina U ^a   Kreuter, Alexander ^b   Rozynkowski, Martha C ^a   Rahmel, Tim ^a   Uhl, Waldemar ^b   Tannapfel, Andrea ^b   Schmidt, Wolfgang E ^a   Meier, Juris J ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Beta cell replication; Ki67; MCM7; PCNA

Indexed keywords

CYCLINE; INSULIN; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 7;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; EXOCRINE CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

ADULT; BIOLOGICAL MARKERS; CELL PROLIFERATION; HUMANS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MIDDLE AGED;

EID: 77952668617     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.12.021     Document Type: Article

References (48)

1. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965, 14:619-633.
2. Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
3. Meier J.J., Bhushan A., Butler A.E., Rizza R.A., Butler P.C. Sustained beta-cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?. Diabetologia 2005, 48:2221-2228.
4. Meier J.J., Bhushan A., Butler P.C. The potential for stem cell therapy in diabetes. Pediatr Res 2006, 59:65R-73R.
5. Levine F., Itkin-Ansari P. beta-cell Regeneration: neogenesis, replication or both?. J Mol Med 2008, 86:247-258.
6. Butler P.C., Meier J.J., Butler A.E., Bhushan A. The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab 2007, 3:758-768.
7. Ritzel R.A. Therapeutic approaches based on beta-cell mass preservation and/or regeneration. Front Biosci 2009, 14:1835-1850.
8. Bouwens L., Pipeleers D.G. Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia 1998, 41:629-633.
9. Bonner-Weir S., Baxter LA Schuppin G.T., Smith F.E. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 1993, 42:1715-1720.
10. Meier J.J., Lin J.C., Butler A.E., Galasso R., Martinez D.S., Butler P.C. Direct evidence of attempted beta-cell regeneration in an 89-year old patient with recent onset type 1 diabetes. Diabetologia 2006, 49:1838-1844.
11. Meier J.J. Beta cell mass in diabetes: a realistic therapeutic target?. Diabetologia 2008, 51:703-713. [Electronic publication 2008 Mar 2004].
12. Meier J.J., Butler A.E., Saisho Y., Monchamp T., Galasso R., Bhushan A., Rizza R.A., Butler P.C. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 2008, 57:1584-1594. [Electronic publication 2008 Mar 1511].
13. Taupin P. BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation. Brain Res Rev 2007, 53:198-214.
14. Panzuto F., Nasoni S., Falconi M., Corleto V.D., Capurso G., Cassetta S., Di Fonzo M., Tornatore V., Milione M., Angeletti S., Cattaruzza M.S., Ziparo V., Bordi C., Pederzoli P., Delle Fave G. Prognostic factors and survival in endocrine tumor patients: comparison between gastrointestinal and pancreatic localization. Endocr Relat Cancer 2005, 12:1083-1092.
15. Menge B.A., Tannapfel A., Belyaev O., Drescher R., Muller C., Uhl W., Schmidt W.E., Meier J.J. Partial pancreatectomy in adult humans does not provoke beta-cell regeneration. Diabetes 2008, 57:142-149. [Electronic publication 2007 Oct 2024].
16. Schluter C., Duchrow M., Wohlenberg C., Becker M.H., Key G., Flad H.D., Gerdes J. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 1993, 123:513-522.
17. Yang J., Ramnath N., Moysich K.B., Asch H.L., Swede H., Alrawi S.J., Huberman J., Geradts J., Brooks J.S., Tan D. Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer 2006, 6:203.
18. Limesand S.W., Jensen J., Hutton J.C., Hay W.W. Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol 2005, 288:R1297-R1305.
19. Wei H., Wang C., Chen L. Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha. Pancreas 2006, 32:159-163.
20. Makinen K., Loimas S., Hakala T., Eskelinen M. Tumour suppressor protein [p53], apoptosis inhibiting protein [Bcl-2] and proliferating cell nuclear antigen [PCNA] expressions in a rat pancreatic tumour model. Anticancer Res 2007, 27:23-26.
21. Essers J., Theil A.F., Baldeyron C., van Cappellen W.A., Houtsmuller A.B., Kanaar R., Vermeulen W. Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol 2005, 25:9350-9359.
22. Freeman A., Morris L.S., Mills A.D., Stoeber K., Laskey R.A., Williams G.H., Coleman N. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 1999, 5:2121-2132.
23. Laskey R. The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation. Philos Trans R Soc Lond B Biol Sci 2005, 360:1119-1132.
24. Padmanabhan V., Callas P., Philips G., Trainer T.D., Beatty B.G. DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancer. J Clin Pathol 2004, 57:1057-1062.
25. Grutzmann R., Pilarsky C., Ammerpohl O., Luttges J., Bohme A., Sipos B., Foerder M., Alldinger I., Jahnke B., Schackert H.K., Kalthoff H., Kremer B., Kloppel G., Saeger H.D. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Neoplasia 2004, 6:611-622.
26. Meier J.J., Menge B.A., Breuer T.G., Muller C.A., Tannapfel A., Uhl W., Schmidt W.E., Schrader H. Functional assessment of pancreatic beta-cell area in humans. Diabetes 2009, 58:1595-1603.
27. Halban P.A. Cell therapy for type 2 diabetes: is it desirable and can we get it?. Diabetes Obes Metab 2008, 10(Suppl 4):205-211.
28. Meier J.J., Butler A.E., Galasso R., Rizza R.A., Butler P.C. Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. Diabetologia 2006, 49:2689-2696.
29. Meier J.J., Butler A.E., Galasso R., Butler P.C. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care 2006, 29:1554-1559.
30. Bannigan J., Langman J. The cellular effect of 5-bromodeoxyuridine on the mammalian embryo. J Embryol Exp Morphol 1979, 50:123-135.
31. Chen S., Turner S., Tsang E., Stark J., Turner H., Mahsut A., Keifer K., Goldfinger M., Hellerstein M.K. Measurement of pancreatic islet cell proliferation by heavy water labeling. Am J Physiol Endocrinol Metab 2007, 293:E1459-E1464.
32. Jones A.S., Roland N.J., Caslin A.W., Cooke T.G., Cooke L.D., Forster G. A comparison of cellular proliferation markers in squamous cell carcinoma of the head and neck. J Laryngol Otol 1994, 108:859-864.
33. Pich A., Ponti R., Valente G., Chiusa L., Geuna M., Novero D., Palestro G. MIB-1, Ki67, and PCNA scores and DNA flow cytometry in intermediate grade malignant lymphomas. J Clin Pathol 1994, 47:18-22.
34. Nordstrom B., Strang P., Bergstrom R., Nilsson S., Tribukait B. A comparison of proliferation markers and their prognostic value for women with endometrial carcinoma. Ki-67, proliferating cell nuclear antigen, and flow cytometric S-phase fraction. Cancer 1996, 78:1942-1951.
35. Xue W.C., Khoo U.S., Ngan H.Y., Chan K.Y., Chiu P.M., Tsao S.W., Cheung A.N. Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters. Histopathology 2003, 43:485-490.
36. Li S.S., Xue W.C., Khoo U.S., Ngan H.Y., Chan K.Y., Tam I.Y., Chiu P.M., Ip P.P., Tam K.F., Cheung A.N. Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis. Histopathology 2005, 46:307-313.
37. Fujioka S., Shomori K., Nishihara K., Yamaga K., Nosaka K., Araki K., Haruki T., Taniguchi Y., Nakamura H., Ito H. Expression of minichromosome maintenance 7 [MCM7] in small lung adenocarcinomas [pT1]: prognostic implication. Lung Cancer 2009, 65:223-229.
38. Fujita M., Kiyono T., Hayashi Y., Ishibashi M. hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. J Biol Chem 1996, 271:4349-4354.
39. Shohet J.M., Hicks M.J., Plon S.E., Burlingame S.M., Stuart S., Chen S.Y., Brenner M.K., Nuchtern J.G. Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. Cancer Res 2002, 62:1123-1128.
40. Celis J.E., Celis A. Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc Natl Acad Sci U S A 1985, 82:3262-3266.
41. Kurki P., Vanderlaan M., Dolbeare F., Gray J., Tan E.M. Expression of proliferating cell nuclear antigen [PCNA]/cyclin during the cell cycle. Exp Cell Res 1986, 166:209-219.
42. Jaskulski D., deRiel J.K., Mercer W.E., Calabretta B., Baserga R. Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science 1988, 240:1544-1546.
43. Bruno S., Crissman H.A., Bauer K.D., Darzynkiewicz Z. Changes in cell nuclei during S phase: progressive chromatin condensation and altered expression of the proliferation-associated nuclear proteins Ki-67, cyclin [PCNA], p105, and p34. Exp Cell Res 1991, 196:99-106.
44. Tsurusawa M., Ito M., Zha Z., Kawai S., Takasaki Y., Fujimoto T. Cell-cycle-associated expressions of proliferating cell nuclear antigen and Ki-67 reactive antigen of bone marrow blast cells in childhood acute leukemia. Leukemia 1992, 6:669-674.
45. Forsburg S.L. Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev 2004, 68:109-131.
46. Reers C., Erbel S., Esposito I., Schmied B., Buchler M.W., Nawroth P.P., Ritzel R.A. Impaired islet turnover in human donor pancreata with aging. Eur J Endocrinol 2009, 160:185-191.
47. Perfetti R., Zhou J., Doyle M.E., Egan J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000, 141:4600-4605.
48. Naryzhny S.N. Proliferating cell nuclear antigen: a proteomics view. Cell Mol Life Sci 2008, 65:3789-3808.