Association between androgens, intima-media thickness and the metabolic syndrome in obese adolescent girls

Clinical Endocrinology

Volumn 72, Issue 6, 2010, Pages 770-774

  De Sousa, Gideon ^a   Brodoswki, Christian ^a   Kleber, Michaela ^a   Wunsch, Rainer ^a   Reinehr, Thomas ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADOLESCENT; ADULT; ARTERIAL WALL THICKNESS; ARTICLE; CHILD; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE; BLOOD; BLOOD PRESSURE; BODY MASS; GLUCOSE TOLERANCE TEST; INTIMA; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICS; TUNICA MEDIA;

ADOLESCENT; ANDROGENS; BLOOD PRESSURE; BODY MASS INDEX; CHILD; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; METABOLIC SYNDROME X; OBESITY; ORGAN SIZE; STATISTICS AS TOPIC; TESTOSTERONE; TUNICA INTIMA; TUNICA MEDIA;

EID: 77952653298     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03710.x     Document Type: Article

References (44)

1. Korhonen, S., Hippelainen, M., Vanhala, M. et al. (2003) The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study. Fertility and Sterility, 79, 1327 1334.
2. Weinberg, M.E., Manson, J.E., Buring, J.E. et al. (2006) Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women. Metabolism, 55, 1473 1480.
3. Golden, S.H., Ding, J., Szklo, M. et al. (2004) Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study. American Journal of Epidemiology, 160, 540 548.
4. Hauner, H., Ditschuneit, H.H., Pal, S.B. et al. (1988) Fat distribution, endocrine and metabolic profile in obese women with and without hirsutism. Metabolism, 37, 281 286.
5. Ehrmann, D.A. (2005) Polycystic ovary syndrome. New England Journal of Medicine, 352, 1223 1236.
6. Glueck, C.J., Papanna, R., Wang, P. et al. (2003) Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism, 52, 908 915.
7. Cibula, D., Cifkova, R., Fanta, M. et al. (2000) Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome. Human Reproduction, 15, 785 789.
8. Apridonidze, T., Essah, P.A., Iuorno, M.J. et al. (2005) Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 90, 1929 1935.
9. Reaven, G.M. (1991) Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease. American Heart Journal, 121, 1283 1288.
10. Eckel, R.H., Grundy, S.M. Zimmet, P.Z. (2005) The metabolic syndrome. Lancet, 365, 1415 1428.
11. Isomaa, B., Almgren, P., Tuomi, T. et al. (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care, 24, 683 689.
12. Glueck, C.J., Morrison, J.A., Friedman, L.A. et al. (2006) Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents. Metabolism, 55, 508 514.
13. Coviello, A.D., Legro, R.S. Dunaif, A. (2006) Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. Journal of Clinical Endocrinology and Metabolism, 91, 492 497.
14. Richards, G.E., Cavallo, A., Meyer, W.J. III. et al. (1985) Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history. Journal of Pediatrics, 107, 893 897.
15. Reinehr, T., de, S.G., Roth, C.L. et al. (2005) Androgens before and after weight loss in obese children. Journal of Clinical Endocrinology and Metabolism, 90, 5588 5595.
16. Wabitsch, M., Hauner, H., Heinze, E. et al. (1995) Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction. Journal of Clinical Endocrinology and Metabolism, 80, 3469 3475.
17. Silfen, M.E., Denburg, M.R., Manibo, A.M. et al. (2003) Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents. Journal of Clinical Endocrinology and Metabolism, 88, 4682 4688.
18. Reinehr, T., Kiess, W., de Sousa, G. et al. (2006) Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism, 55, 113 118.
19. Davis, P.H., Dawson, J.D., Riley, W.A. et al. (2001) Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine study. Circulation, 104, 2815 2819.
20. Ahluwalia, N., Drouet, L., Ruidavets, J.B. et al. (2006) Metabolic syndrome is associated with markers of subclinical atherosclerosis in a French population-based sample. Atherosclerosis, 186, 345 353.
21. Reinehr, T., Wunsch, R., de Sousa, G. et al. (2008) Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness. Atherosclerosis, 199, 193 200.
22. Kromeyer-Hauschild, K., Wabitsch, M., Geller, F. et al. (2001) Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschrift Für Kinderheilkunde, 149, 807 818.
23. Cole, T.J., Bellizzi, M.C., Flegal, K.M. et al. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. British Medical Journal, 320, 1240 1243.
24. Cole, T.J. (1990) The LMS method for constructing normalized growth standards. European Journal of Clinical Nutrition, 44, 45 60.
25. Kromeyer-Hausschild, K., Gläßer, N. Zellner, K. (2008) Waist circumference percentile in Jena children (Germany) 6 to 18 years of age. Aktuelle Ernährungsmedizin, 33, 116 122.
26. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics, 114, 555 576.
27. Matthews, D.R., Hosker, J.P., Rudenski, A.S. et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412 419.
28. Genuth, S., Alberti, K.G., Bennett, P. et al. (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care, 26, 3160 3167.
29. American Diabetes Association 2004) Diagnosis and classification of diabetes mellitus. Diabetes Care, 27 suppl 1, 5 10.
30. Zimmet, P., Alberti, K.G., Kaufman, F. et al. (2007) The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatric Diabetes, 8, 299 306.
31. Vermeulen, A., Verdonck, L. Kaufman, J.M. (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism, 84, 3666 3672.
32. Wunsch, R., de Sousa, G., Toschke, A.M. et al. (2006) Intima-media thickness in obese children before and after weight loss. Pediatrics, 118, 2334 2340.
33. Braunstein, G.D., Johnson, B.D., Stanczyk, F.Z. et al. (2008) Relations between endogenous androgens and estrogens in postmenopausal women with suspected ischemic heart disease. Journal of Clinical Endocrinology and Metabolism, 93, 4268 4275.
34. Franks, S. (2008) Polycystic ovary syndrome in adolescents. International Journal of Obesity, 32, 1035 1041.
35. Pasquali, R., Casimirri, F., de Iasio, R. et al. (1995) Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. Journal of Clinical Endocrinology and Metabolism, 80, 654 658.
36. Willis, D. Franks, S. (1995) Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin-like growth factor receptor. Journal of Clinical Endocrinology and Metabolism, 80, 3788 3790.
37. Poretsky, L. (1991) On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocrine Reviews, 12, 3 13.
38. Barbieri, R.L., Makris, A., Randall, R.W. et al. (1986) Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. Journal of Clinical Endocrinology and Metabolism, 62, 904 910.
39. Sudi, K.M., Gallistl, S., Borkenstein, M.H. et al. (2001) Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese children. Endocrine, 14, 429 435.
40. Phillips, G.B., Jing, T. Heymsfield, S.B. (2008) Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women. Metabolism, 57, 838 844.
41. Rachmiel, M., Kives, S., Atenafu, E. et al. (2008) Primary amenorrhea as a manifestation of polycystic ovarian syndrome in adolescents: a unique subgroup? Archives of Pediatrics & Adolescent Medicine, 162, 521 525.
42. Hurwitz, E.N. Netterstrom, B. (2001) The intima media thickness and coronary risk factors. International Angiology, 20, 118 125.
43. Bots, M.L., Hofman, A. Grobbee, D.E. (1997) Increased common carotid intima-media thickness. Adaptive response or a reflection of atherosclerosis? Findings from the Rotterdam study. Stroke 28, 2442 2447.
44. Lorenz, M.W., Markus, H.S., Bots, M.L. et al. (2007) Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation, 115, 459 467.