Targeted deletion of NF-κB p50 diminishes the cardioprotection of histone deacetylase inhibition

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 6, 2010, Pages

  Zhang, L X ^a   Zhao, Y ^a   Cheng, G ^b   Guo, T L ^c   Chin, Y E ^a   Liu, P Y ^d   Zhao, T C ^a,d  

^a BROWN UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ischemia; Myocardial infarction; Myocardium

Indexed keywords

HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; LYSINE; SMALL INTERFERING RNA; TRICHOSTATIN A;

ACETYLATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA BINDING; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE DELETION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOPRECIPITATION; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ACETYLATION; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NECROSIS; NF-KAPPA B P50 SUBUNIT; RNA, SMALL INTERFERING; VENTRICULAR FUNCTION, LEFT;

EID: 77952651453     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01015.2009     Document Type: Article

References (46)

1. Antos CL, McKinsey TA, Dreitz M, Hollingsworth LM, Zhang CL, Schreiber K, Rindt H, Gorczynski RJ, Olson EN. Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors. J Biol Chem 278: 28930-28937, 2003. (Pubitemid 36935803)
2. Ashburner BP, Westerheide SD, Baldwin AS Jr. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21: 7065-7077, 2001.
3. Bauerle PA, Baltimore D. NF-κB: ten years after. Cell 87: 13-20, 1996.
4. Chen LF, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-kappa B action regulated by reversible acetylation. Science 293: 1653-1657, 2001. (Pubitemid 32807844)
5. Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications. Cell 103: 263-267, 2000.
6. Deng WG, Wu KK. Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol 171: 6581-6588, 2003. (Pubitemid 37532089)
7. Engelbrecht AM, Niesler C, Page C, Lochner A. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res Cardiol 99: 338-350, 2004. (Pubitemid 39236724)
8. Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1. Biol Chem 274: 11713-11720, 1999. (Pubitemid 129518426)
9. Finnin MS, Donigian JR, Cohen A, Richon VM, Rifkind RA, Marks PA, Breslow R, Pavletich NP. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 401: 188-193, 1999. (Pubitemid 29436325)
10. Fryer RM, Auchampach JA, Gross GJ. Therapeutic receptor targets of ischemic preconditioning. Cardiovasc Res 55: 520-525, 2002.
11. Grozinger CM, Hassig CA, Schreiber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci USA 96: 4868-4873, 1999.
12. Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J 22: 3549-3560, 2008.
13. Gallo P, Latronico MV, Gallo P, Grimaldi S, Borgia F, Todaro M, Jones P, Gallinari P, De Francesco R, Ciliberto G, Steinkühler C, Esposito G, Condorelli G. Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure. Cardiovasc Res 80: 416-424, 2008.
14. Hansen JC, Tse C, Wolffe AP. Structure and function of the core histone N-termini: more than meets the eye. Biochemistry 37: 17637-17644,1998.
15. Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci USA 95: 3519-3524, 1998. (Pubitemid 28173160)
16. Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, Altucci L, Nervi C, Minucci S, Pelicci PG. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 11: 71-76, 2005. (Pubitemid 40215840)
17. Kee HJ, Sohn IS, Nam KI, Park JE, Yin Z, Ahn Y, Jeong MH, Bang YJ, Kim N, Kim JK, Kim KK, Epstein JA, Kook H. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation 113: 51-95, 2006.
18. Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, Olson EN, Hill JA. Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation 113: 2579-25788, 2006. (Pubitemid 43948006)
19. Lee TM, Lin MS, Chang NC. Inhibition of histone deacetylase on ventricular remodeling in infarcted rats. Am J Physiol Heart Circ Physiol 293: H968-H977, 2007.
20. Li RC, Ping P, Zhang J, Wead WB, Cao X, Gao J, Zheng Y, Huang S, Han J, Bolli R. PKC epsilon modulates NF-κ B and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol 279: H1679-H1689, 2000.
21. Li CF, Browder W, Kao RL. Early activation of transcription factor NF-κ B during ischemia in perfuse rat heart. Am J Physiol Heart Circ Physiol 276: H543-H552, 1999. (Pubitemid 29100623)
22. Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389: 251-260, 1997. (Pubitemid 27406632)
23. Maulik N, Sato M, Price BD, Das DK. An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia. FEBS Lett 429: 365-369, 1998. (Pubitemid 28300393)
24. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K, Sawa Y, Kaneda Y, Higaki J, Ogihara T. In vivo transfection of cis element "decoy" against nuclear factor κ B binding site prevents myocardial infarction. Nat Med 3: 894-899, 1997.
25. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemicmyocardium. Circulation 74: 1124-1136, 1986.
26. Ren M, Leng Y, Jeong M, Leeds PR, Chuang DM. Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. J Neurochem 89: 1358-1367, 2004. (Pubitemid 38802657)
27. Sanderson L, Taylor GW, Aboagye EO, Alao JP, Latigo JR, Coombes RC, Vigushin DM. Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin A after intraperitoneal administration to mice. Drug Metab Dispos 32: 1132-1138, 2004. (Pubitemid 39287587)
28. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-κ B. Annu Rev Cell Biol 10: 405-455, 1994.
29. Strahl BD, Allis CD. The language of covalent histone modifications. Nature 403: 41-45, 2000.
30. Tantini B, Fiumana E, Cetrullo S, Pignatti C, Bonavita F, Shantz LM, Giordano E, Muscari C, Flamigni F, Guarnieri C, Stefanelli C, Caldarera CM. Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia. J Mol Cell Cardiol 40: 775-782, 2006. (Pubitemid 43817037)
31. Turner BM. Histone acetylation and an epigenetic code. Bioessays 22: 836-845, 2000.
32. Timmers L, van Keulen JK, Hoefer IE, Meijs MF, van Middelaar B, den Ouden K, van Echteld CJ, Pasterkamp G, de Kleijn DP. Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction. Circ Res 104: 699-706, 2009.
33. Van Wylen DM, Thornton JD, Downey JM. The natural history of preconditioning: cardioprotection depends on duration of transient ischemia and time to subsequent ischemia. Coron Artery Dis 2: 613-619, 1991.
34. Verdin E, Dequiedt F, Kasler HG. Class II histone deacetylases: versatile regulators. Trends Genet 19: 286-923, 2003. (Pubitemid 36507011)
35. Vigushi DM, Coombes RC. Targeted histone deacetylase inhibition for cancer therapy. Curr Cancer Target 4: 205-218, 2004. (Pubitemid 38332557)
36. Vitadello M, Penzo D, Petronilli V, Michieli G, Gomirato S, Menabò R, Di Lisa F, Gorza L. Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia. FASEB J 17: 923-925, 2003.
37. Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol Cell Biol 19: 7816-7827, 1999. (Pubitemid 29493445)
38. Xuan YT, Tang XL, Banerjee S, Takano H, Li RC, Han H, Qiu Y, Li JJ, Bolli R. Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits. Circ Res 84: 1095-1109, 1999. (Pubitemid 29227689)
39. Yoshida M, Kijima M, Akita M, Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265: 17174-17179, 1990. (Pubitemid 20334262)
40. Zhao TC, Cheng G, Zhang LX, Tseng YT, Padbury JF. Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. Cardiovasc Res 76: 473-481, 2007. (Pubitemid 350007465)
41. Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, Shannon RP. Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther 317: 1106-1113, 2006. (Pubitemid 43764114)
42. Zhao TC, Kukreja RC. Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel. J Mol Cell Cardiol 34: 263-277, 2002.
43. Zhao TC, Kukreja RC. Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse. Am J Physiol Heart Circ Physiol 285: H434-H441, 2003.
44. Ishida A, Fujita N, Kitazawa R, Tsuruo T. Transforming growth factorbeta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone. J Biol Chem 277: 26217-26224, 2002. (Pubitemid 34967109)
45. Wang Y, Wu TR, Cai S, Welte T, Chin YE. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol Cell Biol 13: 4505-4512, 2000. (Pubitemid 30396098)
46. Zhao TC, Taher MM, Valerie KC, Kukreja RC. p38 Triggers late preconditioning elicited by anisomycin in heart: involvement of NFkappaB and iNOS. Circ Res 89: 915-922, 2001.