Does medical therapy for thoracic aortic aneurysms really work? Are β-blockers truly indicated? PRO

Cardiology Clinics

Volumn 28, Issue 2, 2010, Pages 255-260

  Elefteriades, John A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aortic dissection; Thoracic aortic aneurysm; Type B dissection; blockers

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GLYCERYL TRINITRATE; NITROPRUSSIDE SODIUM; PROPRANOLOL; TRIMETAPHAN; VASODILATOR AGENT;

ACUTE DISEASE; AORTA DISSECTION; AORTA PRESSURE; BLOOD PRESSURE REGULATION; CHRONIC DISEASE; DISEASE SEVERITY; HEART LEFT VENTRICLE EJECTION TIME; HUMAN; HYPERTENSION; MARFAN SYNDROME; NONHUMAN; PRIORITY JOURNAL; REVIEW; THORACIC AORTA ANEURYSM; TREATMENT INDICATION; TREATMENT OUTCOME; ANEURYSM, DISSECTING; AORTIC ANEURYSM, THORACIC; BLOOD PRESSURE; DRUG EFFECTS; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; PATHOPHYSIOLOGY;

ADRENERGIC BETA-ANTAGONISTS; ANEURYSM, DISSECTING; AORTIC ANEURYSM, THORACIC; BLOOD PRESSURE; HUMANS; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 77952651160     PISSN: 07338651     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccl.2010.02.016     Document Type: Review

References (22)

1. Wheat M.W., Palmer R.F., Barley T.D., et al. Treatment of dissecting aneurysms of the aorta without surgery. J Thorac Cardiovasc Surg 1965, 50:364.
2. Palmer R.F., Wheat M.W. Treatment of dissecting aneurysms of the aorta. Ann Thorac Surg 1967, 4:38-52.
3. Simpson C.F., Boucek R.J. The B-aminopropionitrile fed turkey: a model for detecting potential drug action on arterial tissue. Cardiovasc Res 1983, 17(1):26-32.
4. Boucek R.J., Gunja-Smith J., Noble L., et al. Modulation by propranlol of the lysyl cross-links in elastin and collagen of the aneurysm-prone turkey. Biochem Pharmacol 1983, 32:275-280.
5. Yin F.C., Brin K.P., Ting C.T., et al. Arterial hemodynamics indexes in Marfan's syndrome. Circulation 1989, 79(4):854-862.
6. Fuster V., Andrews P. Medical treatment of the aorta. Cardiol Clin 1999, 17(4):697-715.
7. Moran J.F., Derkac W.M., Conkle D.M. Pharmacologic control of acute aortic dissection in hypertensive dogs. Surg Forum 1978, 29:231-234.
8. Erbel R., Alfonso F., Boileau C., et al. Diagnosis and management of aortic dissection: task force on aortic dissection, European society of cardiology. Eur Heart J 2004, 22(18):1642-1681.
9. Elefteriades J.A., Geha A.S., Cohen L.S. Acute aortic emergencies. House officer guide to ICU care 1994, Lippincott-Raven, New York. 2nd edition.
10. Beaven D.W., Murphy E.A. Dissecting aneurysms during methonium therapy: a report on nine cases treated for hypertension. Br Med J 1956, 49(58):77-80.
11. Shores J., Berger K.R., Murphy E.A., et al. Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome. N Engl J Med 1994, 330(19):1335-1341.
12. Rossi-Foulkes R., Roman M.J., Rosen S.E., et al. Phenotypic features and impact of beta blocker or calcium antagonist therapy on aortic lumen size in the Marfan syndrome. Am J Cardiol 1999, 83:1364-1368.
13. Yetman A.T., Bournemeier R.A., McCrindle B.W., et al. Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilatation in patients with the Marfan syndrome. Am J Cardiol 2005, 95:1125-1127.
14. Nollen GJ, Westerhof BE, Groenink M. Aortic pressure-area relation in Marfan patients with and without beta blocking agents: a new non-invasive approach. Heart 2004;90:314-8.
15. Haouzi A., Berglund H., Pelikan P.C., et al. Heterogeneous aortic response to acute beta-adrenergic blockade in Marfan syndrome. Am Heart J 1997, 133(1):60-63.
16. Groenink M., de Roos A., Mulder B.J., et al. Changes in aortic distensibility and pulse wave velocity assessed with magnetic resonance imaging following beta-blocker therapy in the Marfan syndrome. Am J Cardiol 1998, 82:203-208.
17. Meijboom L.J., Westerhof B.E., Noilen G.J., et al. Beta-blocking therapy in patients with the Marfan syndrome and entire aortic replacement. Eur J Cardiothorac Surg 2004, 26:901-906.
18. Rios A.S., Silber E.N., Bavishi N., et al. Effect of long-term beta-blockade on aortic root compliance in patients with Marfan syndrome. Am Heart J 1999, 137:1051-1061.
19. Kodama K., Nishigami K., Sakamoto T., et al. Tight heart rate control reduces secondary adverse events in patients with Type B aortic dissection. Circulation 2008, 118(Suppl I):S167-S170.
20. Hatzaras I.S., Bible J.E., Kallias G.J., et al. Role of exertion or emotion as inciting events for acute aortic dissection. Am J Cardiol 2007, 100:1470-1472.
21. Elefteriades J.A., Hatzaras I., Tranquilli M.A., et al. Weight lifting and rupture of silent aortic aneurysms. JAMA 2003, 290:2803.
22. Hatzaras I., Tranquilli M., Coady M.A., et al. Weight lifting and aortic dissection: More evidence for a connection. Cardiology 2006, 107(2):103-106.