Fracturing support for the role of systemic retinoid therapy as a cause of bone demineralization

Archives of Dermatology

Volumn 146, Issue 5, 2010, Pages 551-553

  DiGiovanna, John J ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; BEXAROTENE; ETRETIN; ETRETINATE; ISOTRETINOIN; RETINOIC ACID; RETINOL;

ACNE; BONE DEMINERALIZATION; CANCER PREVENTION; CUTANEOUS T CELL LYMPHOMA; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFICACY; DRUG ELIMINATION; ECZEMA; EDITORIAL; FRACTURE; GENETIC SUSCEPTIBILITY; HEADACHE; HUMAN; HYPEROSTOSIS; MUSCULOSKELETAL DISEASE; NONHUMAN; OSTEOPHYTE; PATIENT CARE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PSORIASIS; RECOMMENDED DRUG DOSE; RETINOL INTOXICATION; SKIN CANCER; SKIN DISEASE; SYSTEMIC THERAPY; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; VITAMIN METABOLISM;

BONE DEMINERALIZATION, PATHOLOGIC; FRACTURES, BONE; HUMANS; RETINOIDS; VITAMIN A;

EID: 77952635710     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archdermatol.2010.81     Document Type: Editorial

References (43)

1. DiGiovanna JJ. Systemic retinoid therapy. Dermatol Clin. 2001;19(1):161-167.
2. Peck GL, Olsen TG, Yoder FW, et al. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Engl J Med. 1979;300(7):329-333.
3. Peck GL, Yoder FW. Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid. Lancet. 1976;2(7996):1172-1174.
4. Hathcock JN, Hattan DG, Jenkins MY, McDonald JT, Sundaresan PR, Wilkening VL. Evaluation of vitamin A toxicity. Am J Clin Nutr. 1990;52(2):183-202.
5. Lips P. Hypervitaminosis A and fractures. N Engl J Med. 2003;348(4):347-349.
6. English PB. Clinical communication: a case of hyperostosis due to hypervitaminosis A in a cat. J Small Anim Pract. 1969;10(4):207-212.
7. Gallina AM, Wolke RE, Frier HI, Eaton HD, Helmboldt CF. Bone lesions in mild chronic bovine hypervitaminosis A. Arch Exp Veterinarmed. 1970;24(5):1091-1200.
8. Seawright AA, English PB, Gartner RJ. Hypervitaminosis A and hyperostosis of the cat. Nature. 1965;206(989):1171-1172.
9. Seawright AA, English PB, Gartner RJ. Hypervitaminosis A of the cat. Adv Vet Sci Comp Med. 1970;14:1-27.
10. Seawright AA, Hrdlicka J. Severe retardation of growth with retention and displacement of incisors in young cats fed a diet of raw sheep liver high in vitamin A. Aust Vet J. 1974;50(7):306-315.
11. Rothenberg AB, Berdon WE, Woodard JC, Cowles RA. Hypervitaminosis A-induced premature closure of epiphyses (physeal obliteration) in humans and calves (hyena disease): a historical review of the human and veterinary literature. Pediatr Radiol. 2007;37(12):1264-1267.
12. Bartolozzi G, Bernini G, Marianelli L, Corvaglia E. Chronic hypervitaminosis A in infants, and children: description of 2 cases and critical review of the literature. Riv Clin Pediatr. 1967;80(4):231-290.
13. DiGiovanna JJ, Peck GL. Oral synthetic retinoid treatment in children. Pediatr Dermatol. 1983;1(1):77-88. (Pubitemid 14152415)
14. DiGiovanna JJ, Sollitto RB, Abangan DL, Steinberg SM, Reynolds JC. Osteoporosis is a toxic effect of long-term etretinate therapy. Arch Dermatol. 1995;131(11): 1263-1267.
15. DiGiovanna JJ. Isotretinoin effects on bone. J Am Acad Dermatol. 2001;45(5):S176-S182.
16. Silverman AK, Ellis CN, Voorhees JJ. Hypervitaminosis A syndrome: a paradigm of retinoid side effects. J Am Acad Dermatol. 1987;16(5, pt 1):1027-1039. (Pubitemid 17073138)
17. DiGiovanna JJ, Helfgott RK, Gerber LH, Peck GL. Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate. N Engl J Med. 1986;315(19):1177-1182.
18. Gerber LH, Helfgott RK, Gross EG, Hicks JE, Ellenberg SS, Peck GL. Vertebral abnormalities associated with synthetic retinoid use. J Am Acad Dermatol. 1984; 10(5, pt 1):817-823.
19. Milstone LM, McGuire J, Ablow RC. Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid. J Am Acad Dermatol. 1982;7(5):663-666. (Pubitemid 12000536)
20. Wendling D, Hafsaoui C, Laurain JM, Runge M, Magy-Bertrand N, Prati C. Dysphagia and hypervitaminosis A: cervical hyperostosis. Joint Bone Spine. 2009; 76(4):409-411.
21. Brun P, Baran R. Neonatal ichthyosis treated for seven years with etretinate without effects on growth or ossification: a case report. Curr Ther Res. 1986;40(4): 657-663.
22. Ellis CN, Voorhees JJ. Etretinate therapy. J Am Acad Dermatol. 1987;16(2, pt 1): 267-291.
23. Gilbert M, Ellis CN, Voorhees JJ. Lack of skeletal radiographic changes during short-term etretinate therapy for psoriasis. Dermatologica. 1986;172(3):160-163. (Pubitemid 16167304)
24. Glover MT, Peters AM, Atherton DJ. Surveillance for skeletal toxicity of children treated with etretinate. Br J Dermatol. 1987;116(5):609-614.
25. Halkier-Sørensen L, Andresen J. A retrospective study of bone changes in adults treated with etretinate. J Am Acad Dermatol. 1989;20(1):83-87. (Pubitemid 19033851)
26. McGuire J, Lawson JP. Skeletal changes associated with chronic isotretinoin and etretinate administration. Dermatologica. 1987;175(suppl 1):169-181. (Pubitemid 17164527)
27. Okada N, Nomura M, Morimoto S, Ogihara T, Yoshikawa K. Bone mineral density of the lumbar spine in psoriatic patients with long term etretinate therapy. J Dermatol. 1994;21(5):308-311. (Pubitemid 24225124)
28. Ruiz-Maldonado R, Tamayo L. Retinoids in disorders of keratinization: their use in children. Dermatologica. 1987;175(suppl 1):125-132. (Pubitemid 17164521)
29. KocijancicM.13-cis-retinoic acidandbonedensity. Int J Dermatol. 1995;34(10):733-734.
30. Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone densities in patients receiving isotretinoin for cystic acne. Arch Dermatol. 1999;135(8):961-965.
31. Margolis DJ, Attie M, Leyden JJ. Effects of isotretinoin on bone mineralization during routine therapy with isotretinoin for acne vulgaris. Arch Dermatol. 1996; 132(7):769-774.
32. DiGiovanna JJ, Langman CB, Tschen EH, et al. Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne. J Am Acad Dermatol. 2004;51(5):709-717.
33. Lenchik L, Leib ES, Hamdy RC, Binkley NC, Miller PD, Watts NB; International Society for Clinical Densitometry Position Development Panel and Scientific Advisory Committee. Executive summary International Society for Clinical Densitometry position development conference Denver, Colorado, July 20-22, 2001. J Clin Densitom. 2002;5(suppl):S1-S3.
34. Hamdy RC, Petak SM, Lenchik L; International Society for Clinical Densitometry Position Development Panel and Scientific Advisory Committee. Which central dual X-ray absorptiometry skeletal sites and regions of interest should be used to determine the diagnosis of osteoporosis? J Clin Densitom. 2002;5(suppl):S11-S18.
35. Faulkner RA, Davison KS, Bailey DA, Mirwald RL, Baxter-Jones AD. Size-corrected BMD decreases during peak linear growth: implications for fracture incidence during adolescence. J Bone Miner Res. 2006;21(12):1864-1870.
36. Fournier PE, Rizzoli R, Slosman DO, Theintz G, Bonjour JP. Asynchrony between the rates of standing height gain and bone mass accumulation during puberty. Osteoporos Int. 1997;7(6):525-532.
37. Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int. 2000;11(12):985-1009.
38. Erdogan BS, Yuksel D, Aktan S, Ergin S, Kirac FS. The effects of isotretinoin treatment on bone mineral density in patients with nodulocystic acne. J Eur Acad Dermatol Venereol. 2006;20(8):1006-1007. (Pubitemid 44241396)
39. Tekin NS, Ozdolap S, Sarikaya S, Keskin SI. Bone mineral density and bone turn-over markers in patients receiving a single course of isotretinoin for nodulocystic acne. Int J Dermatol. 2008;47(6):622-625. (Pubitemid 351676511)
40. Ribaya-Mercado JD, Blumberg JB. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev. 2007;65(10):425-438. (Pubitemid 351804344)
41. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr. 2006;83(2):191-201. (Pubitemid 44713178)
42. Kawahara TN, Krueger DC, Engelke JA, Harke JM, Binkley NC. Short-term vitamin A supplementation does not affect bone turnover in men. J Nutr. 2002; 132(6):1169-1172.
43. Vestergaard P, Rejnmark L, Mosekilde L. High-dose treatment with vitamin A analogues and risk of fractures. Arch Dermatol. 2010;146(5):478-482.