Raltegravir penetration in seminal plasma of healthy volunteers

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 6, 2010, Pages 2744-2745

  Calcagno, Andrea ^a   Bonora, Stefano ^a   D'Avolio, Antonio ^a   Siccardi, Marco ^a   Simiele, Marco ^a   Chiesa, Mattia ^a   De Requena, Daniel Gonzalez ^a   Di Perri, Giovanni ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RALTEGRAVIR;

ADULT; DRUG BLOOD LEVEL; DRUG PENETRATION; HUMAN; HUMAN EXPERIMENT; LETTER; MALE; NORMAL HUMAN; OPEN STUDY; PRIORITY JOURNAL; SEMINAL PLASMA;

ADULT; HIV INTEGRASE INHIBITORS; HUMANS; MALE; PYRROLIDINONES; SEMEN;

EID: 77952600233     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00241-10     Document Type: Letter

References (5)

1. Barau, C., C. Delaugerre, J. Braun, N. de Castro, V. Furlan, I. Charreau, L. Gérard, C. Lascoux-Combe, J. M. Molina, and A. M. Taburet. 2010. High concentration of raltegravir in semen of HIV-infected men: results from a substudy of the EASIER-ANRS 138 trial. Antimicrob. Agents Chemother. 54:937-939.
2. Chan, D. J. 2005. Pathophysiology of HIV-1 in semen: current evidence for compartmentalisation and penetration by antiretroviral drugs. Curr. HIV Res. 3:207-222.
3. D'Avolio, A., L. Baietto, M. Siccardi, M. Sciandra, M. Simiele, V. Oddone, S. Bonora, and G. Di Perri. 2008. An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients. Ther. Drug Monit. 30:662-669.
4. Jones, A. E., J. A. Talameh, K. B. Patterson, N. L. Rezk, H. A. Prince, and A. D. M. Kashuba. 2009. First-dose and steady-state pharmacokinetics of raltegravir in the genital tract of HIV negative women, abstr. O-06. Abstr. 10th Int. Workshop Clin. Pharmacol. HIV Ther., Amsterdam, Netherlands, 15 April to 1 May 2009.
5. Kalichman, S. C., G. Di Berto, and L. Eaton. 2008. Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings. Sex. Transm. Dis. 35:55-60.