An enzymatic model of the growth hormone-releasing hormone oscillator incorporating neuronal synchronization

Journal of Theoretical Biology

Volumn 264, Issue 3, 2010, Pages 984-989

  Caplan, S Roy ^a,b   Tannenbaum, Gloria S ^b   Johnstone, Rose M ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Baselator; GHRH; Hyperneuron; Primer; Pulse

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; PHOSPHATASE; PHOSPHOTRANSFERASE;

ENZYME ACTIVITY; HORMONE; MODELING;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SYNCHRONIZATION; CHEMICAL REACTION KINETICS; ENZYME ACTIVITY; ENZYME MECHANISM; EXOCYTOSIS; FEEDBACK SYSTEM; GAP JUNCTION; GROWTH HORMONE RELEASE; MATHEMATICAL MODEL; NERVE CELL; NERVE ENDING; OSCILLATOR; PHOSPHORYLATION AND DEPHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; CALCIUM; CALCIUM CHANNELS; COMPUTER SIMULATION; EXOCYTOSIS; FEEDBACK, PHYSIOLOGICAL; GROWTH HORMONE-RELEASING HORMONE; HUMANS; KINETICS; MODELS, BIOLOGICAL; NERVE NET; NEURONS;

EID: 77952594259     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2010.02.042     Document Type: Article

References (18)

1. Balthasar N., Mery P.-F., Magoulas C.B., Mathers K.E., Martin A., Mollard P., Robinson I.C.A.F. Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: a ventral hypothalamic network. Endocrinology 2003, 144:2728-2740.
2. Borisovska M., Zhao Y., Tsytsyura Y., Glyvuk N., Takamori S., Matti U., Rettig J., Südhof T., Bruns D. v-SNAREs control exocytosis of vesicles from priming to fusion. EMBO J. 2005, 24:2114-2126.
3. Caplan S.R., Essig A. Bioenergetics and linear Nonequilibrium Thermodynamics 1983, Harvard University Press, Cambridge, Mass.
4. Farhy L.S., Straume M., Johnson M.l., Kovatchev B., Veldhuis J.D. A construct of interactive feedback control of the GH axis in the male. Am. J. Physiol. 2001, 281:R38-R51.
5. Hameroff S. Consciousness, neurobiology and quantum mechanics: the case for a connection. The Emerging Physics of Consciousness 2006, 193. Springer, New York. J.A. Tuszynski (Ed.).
6. Hofer P., Fringeli U.P. Acetylcholinesterase kinetics. Eur. Biophys. J. 1980, 6(Suppl. 1):41.
7. Lipkow K., Andrews S.S., Bray D. Simulated diffusion of phosphorylated CheY through the cytoplasm of Escherichia coli. J. Bacteriol. 2005, 187:45-53.
8. Mehra A., Hong C.I., Shi M., Loros J.J., Dunlap J.C., Ruoff P. Circadian rhythmicity by autocatalysis. PLoS Comput. Biol. 2006, 2(7):e96. 10.1371/journal.pcbi.0020096.
9. Reits E., Griekspoor A., Neijssen J., Groothuis T., Jalink K., van Veelen P., Janssen H., Calafat J., Drijfhout J.W., Neefjes J. Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC Class I. Immunity 2003, 18:97-108.
10. Robinson, I.C.A.F., Hindmarsh, P.C., 1999. The growth hormone secretory pattern and statural growth. In: Handbook of Physiology, Section 7: The Endocrine System, vol. V: Hormonal Control of Growth. Kostyo, J.L. (volume editor), Goodman, H.M. (section editor), Oxford University Press, New York, pp. 329-395.
11. Schilstra M.J., Veldink G.A., Vliegenthart J.F.G. Kinetic analysis of the induction period in lipoxygenase catalysis. Biochemistry 1993, 32:7686-7691.
12. Shiosaka S., Yamamoto T., Hertzberg E.L., Nagy J.L. Gap junction protein in rat hippocampus: correlative light and electron microscope immuno-histochemical localization. J. Comp. Neurol. 1989, 281:282-297.
13. Tannenbaum G.S., Martin J.B. Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 1976, 98:562-570.
14. Traub R.D., Draguhn A., Whittington M.A., Baldeweg T., Bibbig A., Buhl E.H., Schmitz D. Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis. Rev. Neurosci. 2002, 13:1-30.
15. Wagner C., Caplan S.R., Tannenbaum G.S. Genesis of the ultradian rhythm of growth hormone secretion: a new model unifying experimental observations in rats. Am. J. Physiol. 1998, 275:E1046-E1054.
16. Wagner C., Caplan S.R., Tannenbaum G.S. Interactions of ghrelin signaling pathways with the growth hormone neuroendocrine axis: a new and experimentally tested model. J. Mol. Endocrinol. 2009, 43:105-119.
17. Walz D. Biothermokinetics of processes and energy conversion. Biochim. Biophys. Acta 1990, 1019:171-224.
18. Walz D., Caplan S.R. Chemical oscillations arise solely from kinetic nonlinearity and hence can occur near equilibrium. Biophys. J. 1995, 69:1698-1707.