Attitudes to drug trials among relatives of unconscious intensive care patients

BMC Anesthesiology

Volumn 10, Issue , 2010, Pages

  Perner, Anders ^a   Ibsen, Michael ^a   Bonde, Jan ^a  

^a Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; DENMARK; DRUG SCREENING; FAMILY ATTITUDE; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; INFORMED CONSENT; INTENSIVE CARE; MALE; PATIENT CARE; QUESTIONNAIRE; RISK BENEFIT ANALYSIS; SUBURBAN AREA; UNCONSCIOUSNESS;

EID: 77952592332     PISSN: None     EISSN: 14712253     Source Type: Journal    
DOI: 10.1186/1471-2253-10-6     Document Type: Article

References (14)

1. Harvey SE, Elbourne D, Ashcroft J, Jones CM, Rowan K. Informed consent in clinical trials in critical care: experience from the PAC-Man Study. Intensive Care Med 2006, 32:2020-2025. 10.1007/s00134-006-0358-4, 17019555.
2. Lemaire F, Bion J, Blanco J, Damas P, Druml C, Falke K, Kesecioglu J, Larsson A, Mancebo J, Matamis D, Pesenti A, Pimentel J, Ranieri M. The European Union Directive on Clinical Research: present status of implementation in EU member states' legislations with regard to the incompetent patient. Intensive Care Med 2005, 31:476-479. 10.1007/s00134-005-2574-8, 15711974.
3. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999, 340:409-417. 10.1056/NEJM199902113400601, 9971864.
4. Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008, 358:877-887. 10.1056/NEJMoa067373, 18305265.
5. Madsen SM, Mirza MR, Holm S, Hilsted KL, Kampmann K, Riis P. Attitudes towards clinical research amongst participants and nonparticipants. J Intern Med 2002, 251:156-168. 10.1046/j.1365-2796.2002.00949.x, 11905591.
6. Vincent JL, Moreno R, Takala J, Willatts S, De MA, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239.
7. Chenaud C, Merlani P, Verdon M, Ricou B. Who should consent for research in adult intensive care? Preferences of patients and their relatives: a pilot study. J Med Ethics 2009, 35:709-712. 10.1136/jme.2008.028068, 19880710.
8. Burgess E, Singhal N, Amin H, McMillan DD, Devrome H. Consent for clinical research in the neonatal intensive care unit: a retrospective survey and a prospective study. Arch Dis Child Fetal Neonatal Ed 2003, 88:F280-F285. 10.1136/fn.88.4.F280, 1721584, 12819158.
9. Ciroldi M, Cariou A, Adrie C, Annane D, Castelain V, Cohen Y, Delahaye A, Joly LM, Galliot R, Garrouste-Org, Papazian L, Michel F, Barnes NK, Schlemmer B, Pochard F, Azoulay E. Ability of family members to predict patient's consent to critical care research. Intensive Care Med 2007, 33:807-813. 10.1007/s00134-007-0582-6, 17361388.
10. Azoulay E, Pochard F, Chevret S, Adrie C, Annane D, Bleichner G, Bornstain C, Bouffard Y, Cohen Y, Feissel M, Goldgran-Toledano D, Guitton C, Hayon J, Iglesias E, Joly LM, Jourdain M, Laplace C, Lebert C, Pingat J, Poisson C, Renault A, Sanchez O, Selcer D, Timsit JF, Le G, Schlemmer B. Half the family members of intensive care unit patients do not want to share in the decision-making process: a study in 78 French intensive care units. Crit Care Med 2004, 32:1832-1838. 10.1097/01.CCM.0000139693.88931.59, 15343009.
11. Scales DC, Smith OM, Pinto R, Barrett KA, Friedrich JO, Lazar NM, Cook DJ, Ferguson ND. Patients' preferences for enrolment into critical-care trials. Intensive Care Med 2009, 35:1703-1712. 10.1007/s00134-009-1552-y, 19551372.
12. Jansen TC, Kompanje EJ, Bakker J. Deferred proxy consent in emergency critical care research: ethically valid and practically feasible. Crit Care Med 2009, 37:S65-S68. 10.1097/CCM.0b013e3181920851, 19104227.
13. Annane D, Outin H, Fisch C, Bellissant E. The effect of waiving consent on enrollment in a sepsis trial. Intensive Care Med 2004, 30:321-324. 10.1007/s00134-003-2065-8, 14714106.
14. Lemaire F. Informed consent for and regulation of critical care research. Curr Opin Crit Care 2008, 14:696-699. 10.1097/MCC.0b013e328315a62, 19005312.