A Deletion Polymorphism in Glutathione-S-Transferase Mu (GSTM1) and/or Theta (GSTT1) Is Associated with an Increased Risk of Toxicity after Autologous Blood and Marrow Transplantation

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 6, 2010, Pages 801-808

  Hahn, Theresa ^a   Zhelnova, Eugenia ^b   Sucheston, Lara ^a   Demidova, Irina ^b   Savchenko, Valery ^b   Battiwalla, Minoo ^a   Smiley, Shannon L ^a   Ambrosone, Christine B ^a   McCarthy, Philip L ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NATIONAL RESEARCH CENTER FOR HEMATOLOGY   (Russian Federation)

Author keywords

Autologous and allogeneic BMT; Glutathione S transferase; Polymorphisms; Regimen related toxicity

Indexed keywords

BUSULFAN; CALCINEURIN INHIBITOR; CARBOPLATIN; CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; DNA; ETOPOSIDE; FLUDARABINE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE MU; GLUTATHIONE TRANSFERASE THETA; MELPHALAN; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISONE; THIOTEPA; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BLADDER DISEASE; BREAST CANCER; CANCER SURVIVAL; CARDIOTOXICITY; CENTRAL NERVOUS SYSTEM DISEASE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL TOXICITY; GENE AMPLIFICATION; GENE DELETION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HODGKIN DISEASE; HOMOZYGOTE; HUMAN; LIVER TOXICITY; LUNG TOXICITY; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIPLE MYELOMA; MUTATIONAL ANALYSIS; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; NEPHROTOXICITY; NONHODGKIN LYMPHOMA; RUSSIAN FEDERATION; UNITED STATES; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; BONE MARROW TRANSPLANTATION; CHILD; CONTINENTAL POPULATION GROUPS; DRUG TOXICITY; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HEMATOLOGIC NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOSCOW; NEW YORK; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; POLYMORPHISM, GENETIC; RADIATION INJURIES; RISK; RISK FACTORS; SEQUENCE DELETION; SURVIVAL ANALYSIS; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION; YOUNG ADULT;

EID: 77952584497     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.01.001     Document Type: Article

References (26)

1. Hayes J.D., Ellis E.M., Neal G.E., Harrison D.J., Manson M.M. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress. Biochem Soc Symp 1999, 64:141-168.
2. Ambrosone C.B., Tian C., Ahn J., et al. Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study. Breast Cancer Res 2006, 8:R40.
3. Sun J., Chen Y., Li M., Ge Z. Role of antioxidant enzymes on ionizing radiation resistance. Free Radic Biol Med 1998, 24:586-593.
4. Ritter C.A., Sperker B., Grube M., Dressel D., Kunert-Keil C., Kroemer H.K. Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol 2002, 137:1100-1106.
5. Czerwinski M., Gibbs J.P., Slattery J.T. Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos 1996, 24:1015-1019.
6. Dirven H.A., van Ommen B., van Bladeren P.J. Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione. Cancer Res 1994, 54:6215-6220.
7. Hayes J.D., McLellan L.I. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 1999, 31:273-300.
8. Paumi C.M., Ledford B.G., Smitherman P.K., Townsend A.J., Morrow C.S. Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity. J Biol Chem 2001, 276:7952-7956.
9. Bruhn C., Brockmoller J., Kerb R., Roots I., Borchert H.H. Concordance between enzyme activity and genotype of glutathione S-transferase theta (GSTT1). Biochem Pharmacol 1998, 56:1189-1193.
10. Hayes J.D., Strange R.C. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology 2000, 61:154-166.
11. Srivastava A., Poonkuzhali B., Shaji R.V., et al. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood 2004, 104:1574-1577.
12. Goekkurt E., Stoehlmacher J., Stueber C., et al. Pharmacogenetic analysis of liver toxicity after busulfan/cyclophosphamide-based allogeneic hematopoietic stem cell transplantation. Anticancer Res 2007, 27:4377-4380.
13. Terakura S., Murata M., Nishida T., et al. Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients. Bone Marrow Transplant 2006, 37:381-386.
14. Ueda K., Ishitsu T., Seo T., et al. Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity. Pharmacogenomics 2007, 8:435-442.
15. Fukushima Y., Seo T., Hashimoto N., Higa Y., Ishitsu T., Nakagawa K. Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for increased serum gamma-glutamyltransferase in valproic acid-treated patients. Clin Chim Acta 2008, 389:98-102.
16. Lucena M.I., Andrade R.J., Martinez C., et al. Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury. Hepatology 2008, 48:588-596. Spanish Group for the Study of Drug-Induced Liver Disease.
17. Arand M., Mühlbauer R., Hengstler J., et al. A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal Biochem 1996, 236:184-186.
18. Garte S., Gaspari L., Alexandrie A.K., et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev 2001, 10:1239-1248.
19. Bigatti M.P., Santovito A. Glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) polymorphisms in a sample of the population in Northern Italy. Genetika 2007, 43:827-830.
20. Suarez-Kurtz G., Vargens D.D., Struchiner C.J., Bastos-Rodrigues L., Pena S.D. Self-reported skin color, genomic ancestry and the distribution of GST polymorphisms. Pharmacogenet Genomics 2007, 17:765-771.
21. Adams C.H., Werely C.J., Victor T.C., Hoal E.G., Rossouw G., van Helden P.D. Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence. Clin Chem Lab Med 2003, 41:600-605.
22. Bearman S.I., Appelbaum F.R., Buckner C.D., et al. Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 1988, 6:1562-1568.
23. Davies S.M., Radloff G.A., Defor T., Batish S.D., Giampetro P.F., Auerbach A.D. Clinical phenotype of fanconi anemia is influenced by polymorphism in glutathione-S-transferase theta. Blood 2001, 98:783a.
24. Naoe T., Tagawa Y., Kiyoi H., et al. Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy. Leukemia 2002, 16:203-208.
25. Rocha V., Porcher R., Fernandes J.F., et al. Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia. Leukemia 2009, 23:545-556.
26. Bauer V., Bauer F. Reactive oxygen species as mediators of tissue protection and injury. Gen Physiol Biophys 1999, 18:7-14.