Preventing AID, a physiological mutator, from deleterious activation: Regulation of the genomic instability that is associated with antibody diversity

International Immunology

Volumn 22, Issue 4, 2010, Pages 227-235

  Nagaoka, Hitoshi ^a   Tran, Thinh Huy ^b   Kobayashi, Maki ^a   Aida, Masatoshi ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b RIKEN   (Japan)

Author keywords

Aicda; B cell; Top1; Transcription; Tumorigenesis

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; DNA TOPOISOMERASE; IMMUNOGLOBULIN; NEUROGENIC DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR PAX5;

ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; CARCINOGENESIS; DNA CLEAVAGE; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENE TARGETING; GENOMIC INSTABILITY; HUMAN; LYMPHOCYTE ACTIVATION; MOLECULAR EVOLUTION; NONHUMAN; ONCOGENE; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; CYTIDINE DEAMINASE; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; ENHANCER ELEMENTS, GENETIC; GENE SILENCING; GENOMIC INSTABILITY; HUMANS; IMMUNOGLOBULIN G; JAPAN; PROTO-ONCOGENES; TRANSCRIPTION, GENETIC;

EID: 77952583868     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq023     Document Type: Article

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