Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer

Radiotherapy and Oncology

Volumn 95, Issue 3, 2010, Pages 303-307

  Shin, Sang Joon ^a   Kim, Nam Kyu ^a   Keum, Ki Chang ^a   Kim, Ho Geun ^a   Im, Jun Seok ^b   Choi, Hye Jin ^a   Baik, Seung Hyuk ^a   Choen, Jae Hee ^a   Jeung, Hei Cheul ^a   Rha, Sun Young ^a   Roh, Jae Kyung ^a   Chung, Hyun Cheol ^a   Ahn, Joong Bae ^a  

^a Department of Internal Medicine ^*

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Irinotecan; Preoperative chemoradiotherapy; Rectal cancer; S 1

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; IRINOTECAN;

ABDOMINAL PAIN; ADULT; AGED; ANAL PAIN; ANEMIA; ANOREXIA; ANUS DISEASE; ARTICLE; BLADDER DISEASE; BLOOD TOXICITY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; COLON RESECTION; DIARRHEA; FATIGUE; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; INCONTINENCE; INFECTION; MALE; NEUTROPENIA; OUTCOME ASSESSMENT; PHASE 2 CLINICAL TRIAL; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RADIATION SICKNESS; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CANCER; RECTUM SURGERY; SEPSIS; SEPTIC SHOCK; TREATMENT FAILURE; URINARY TRACT INFECTION;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; OXONIC ACID; RECTAL NEOPLASMS; TEGAFUR;

EID: 77952581386     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.02.003     Document Type: Article

References (34)

1. Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
2. Bosset J.F., Collette L., Calais G., et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355 (2006) 1114-1123
3. Gerard J.P., Conroy T., Bonnetain F., et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 24 (2006) 4620-4625
4. Rodel C., Martus P., Papadoupolos T., et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23 (2005) 8688-8696
5. Vecchio F.M., Valentini V., Minsky B.D., et al. The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys 62 (2005) 752-760
6. Theodoropoulos G., Wise W.E., Padmanabhan A., et al. T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 45 (2002) 895-903
7. Kuo L.J., Liu M.C., Jian J.J., et al. Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy?. Ann Surg Oncol 14 (2007) 2766-2772
8. Bouzourene H., Bosman F.T., Seelentag W., Matter M., and Coucke P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 94 (2002) 1121-1130
9. Saltz L.B., Cox J.V., Blanke C., et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343 (2000) 905-914
10. Rich T.A., and Kirichenko A.V. Camptothecin schedule and timing of administration with irradiation. Oncology (Williston Park) 15 (2001) 37-41
11. Shirasaka T., Shimamato Y., Ohshimo H., et al. Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 7 (1996) 548-557
12. Choi H.J., Kim N.K., Keum K.C., et al. Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer. Radiother Oncol 87 (2008) 361-366
13. Kim J.H., Beets G.L., Kim M.J., Kessels A.G., and Beets-Tan R.G. High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size?. Eur J Radiol 52 (2004) 78-83
14. Mandard A.M., Dalibard F., Mandard J.C., et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer 73 (1994) 2680-2686
15. Sanghera P., Wong D.W., McConkey C.C., Geh J.I., and Hartley A. Chemoradiotherapy for rectal cancer: an updated analysis of factors affecting pathological response. Clin Oncol (R Coll Radiol) 20 (2008) 176-183
16. Glynne-Jones R., Dunst J., and Sebag-Montefiore D. The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?. Ann Oncol 17 (2006) 361-371
17. Dunst J., Reese T., Sutter T., et al. Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J Clin Oncol 20 (2002) 3983-3991
18. Ngan S.Y., Michael M., Mackay J., et al. A phase I trial of preoperative radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer. Br J Cancer 91 (2004) 1019-1024
19. Souglakos J., Androulakis N., Mavroudis D., et al. Multicenter dose-finding study of concurrent capecitabine and radiotherapy as adjuvant treatment for operable rectal cancer. Int J Radiat Oncol Biol Phys 56 (2003) 1284-1287
20. Kim J.S., Cho M.J., Song K.S., and Yoon W.H. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 54 (2002) 403-408
21. Kim J.C., Kim T.W., Kim J.H., et al. Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 63 (2005) 346-353
22. Krishnan S., Janjan N.A., Skibber J.M., et al. Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 66 (2006) 762-771
23. Diaz-Gonzalez J.A., Calvo F.A., Cortes J., et al. Preoperative chemoradiation with oral tegafur within a multidisciplinary therapeutic approach in patients with T3-4 rectal cancer. Int J Radiat Oncol Biol Phys 61 (2005) 1378-1384
24. Fernandez-Martos C., Aparicio J., Bosch C., et al. Preoperative uracil, tegafur, and concomitant radiotherapy in operable rectal cancer: a phase II multicenter study with 3 years' follow-up. J Clin Oncol 22 (2004) 3016-3022
25. Hofheinz R.D., von Gerstenberg-Helldorf B., Wenz F., et al. Phase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer. J Clin Oncol 23 (2005) 1350-1357
26. Klautke G., Kuchenmeister U., Foitzik T., et al. Concurrent chemoradiation with capecitabine and weekly irinotecan as preoperative treatment for rectal cancer: results from a phase I/II study. Br J Cancer 94 (2006) 976-981
27. Iles S., Gollins S., Susnerwala S., et al. Irinotecan+5-fluorouracil with concomitant pre-operative radiotherapy in locally advanced non-resectable rectal cancer: a phase I/II study. Br J Cancer 98 (2008) 1210-1216
28. Willeke F., Horisberger K., Kraus-Tiefenbacher U., et al. A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer. Br J Cancer 96 (2007) 912-917
29. Mohiuddin M., Winter K., Mitchell E., et al. Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012. J Clin Oncol 24 (2006) 650-655
30. Mehta V.K., Cho C., Ford J.M., et al. Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer. Int J Radiat Oncol Biol Phys 55 (2003) 132-137
31. Sato T., Kokuba Y., Koizumi W., Hayakawa K., Okayasu I., Watanabe M., et al. Trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 69 (2007) 1442-1447
32. Ajani J.A., Faust J., Ikeda K., et al. Phase I pharmacokinetic study of S-1 plus cisplatin in patients with advanced gastric carcinoma. J Clin Oncol 23 (2005) 6957-6965
33. Aschele C., Pinto C., Cordio S., et al. Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: pathologic response analysis of the Studio Terapia Adiuvante Reto (STAR)-01 randomized phase III trial (abstract #4008). J Clin Oncol 27 (2009) 804s
34. Gerard J., Azria D., Gourgou-Bourgade S., et al. Randomized multicenter phase III trial comparing two neoadjuvant chemoradiotherapy (CT-RT) regimens (RT45-Cap versus RT50-Capox) in patients with locally advanced rectal cancer: results of the ACCORD 12/0405 PRODIGE 2 (abstract #4007). J Clin Oncol 27 (2009) 979s