Role of filamentation in Galleria mellonella killing by Candida albicans

Microbes and Infection

Volumn 12, Issue 6, 2010, Pages 488-496

  Fuchs, Beth Burgwyn ^a   Eby, Josh ^a   Nobile, Clarissa J ^b   El Khoury, Joseph B ^a   Mitchell, Aaron P ^b   Mylonakis, Eleftherios ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Candida albicans; Filamentation; Galleria mellonella; Hyphae

Indexed keywords

BCR1 PROTEIN; FLO8 PROTEIN; FUNGAL PROTEIN; KEM1 PROTEIN; SUV3 PROTEIN; TEC1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOFILM; BLOOD CELL; CANDIDA ALBICANS; CONTROLLED STUDY; FEMALE; FUNGAL FILAMENTATION; FUNGAL PHENOMENA AND FUNCTIONS; FUNGAL VIRULENCE; FUNGUS HYPHAE; GALLERIA MELLONELLA; HOST PATHOGEN INTERACTION; LEPIDOPTERA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; ANIMAL; CANDIDIASIS; CYTOCHEMISTRY; DISEASE MODEL; GENETICS; KAPLAN MEIER METHOD; MICROBIOLOGY; MOTH; PATHOGENICITY; PHYSIOLOGY;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; DISEASE MODELS, ANIMAL; FEMALE; HISTOCYTOCHEMISTRY; HYPHAE; KAPLAN-MEIERS ESTIMATE; MICE; MOTHS; KAPLAN-MEIER ESTIMATE;

CANDIDA ALBICANS; GALLERIA MELLONELLA; MAMMALIA;

EID: 77952580828     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2010.03.001     Document Type: Article

References (24)

1. Douglas L.J. Candida biofilms and their role in infection. Trends Microbiol. 11 (2003) 30-36
2. Hawser S.P., and Douglas L.J. Resistance of Candida albicans biofilms to antifungal agents in vitro. Antimicrobial Agents Chemother. 39 (1995) 2128-2131
3. Berman J., and Sudbery P.E. Candida albicans: a molecular revolution built on lessons from budding yeast. Nat. Rev. Genet. 3 (2002) 918-930
4. Kobayashi S.D., and Cutler J.E. Candida albicans hyphal formation and virulence: is there a clearly defined role?. Trends Microbiol. 6 (1998) 92-94
5. Brennan M., Thomas D.Y., Whiteway M., and Kavanagh K. Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae. FEMS Immunol Med Microbiol 34 (2002) 153-157
6. Cotter G., Doyle S., and Kavanagh K. Development of an insect model for the in vivo pathogenicity testing of yeasts. FEMS Immunol. Med. Microbiol. 27 (2000) 163-169
7. Bergin D., Brennan M., and Kavanagh K. Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella. Microbes Infect. 5 (2003) 1389-1395
8. Bergin D., Murphy L., Keenan J., Clynes M., and Kavanagh K. Pre-exposure to yeast protects larvae of Galleria mellonella from a subsequent lethal infection by Candida albicans and is mediated by the increased expression of antimicrobial peptides. Microbes Infect. 8 (2006) 2105-2112
9. Nobile C.J., and Mitchell A.P. Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr. Biol. 15 (2005) 1150-1155
10. Richard M.L., Nobile C.J., Bruno V.M., and Mitchell A.P. Candida albicans biofilm-defective mutants. Eukaryot. Cell 4 (2005) 1493-1502
11. Cao F., Lane S., Raniga P.P., Lu Y., Zhou Z., Ramon K., Chen J., and Liu H. The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans. Mol. Biol. Cell 17 (2006) 295-307
12. Nobile C.J., Solis N., Myers C.L., Fay A.J., Deneault J.S., Nantel A., Mitchell A.P., and Filler S.G. Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions. Cell Microbiol. 10 (2008) 2180-2196
13. Nobile C.J., and Mitchell A.P. Large-scale gene disruption using the UAU1 cassette. Methods Mol. Biol. 499 (2009) 175-194
14. Mylonakis E., Moreno R., El Khoury J.B., Idnurm A., Heitman J., Calderwood S.B., Ausubel F.M., and Diener A. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect. Immun. 73 (2005) 3842-3850
15. Bergin D., Reeves E.P., Renwick J., Wientjes F.B., and Kavanagh K. Superoxide production in Galleria mellonella hemocytes: identification of proteins homologous to the NADPH oxidase complex of human neutrophils. Infect. Immun. 73 (2005) 4161-4170
16. Breger J., Fuchs B.B., Aperis G., Moy T.I., Ausubel F.M., and Mylonakis E. Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathog. 3 (2007) e18
17. Nobile C.J., Andes D.R., Nett J.E., Smith F.J., Yue F., Phan Q.T., Edwards J.E., Filler S.G., and Mitchell A.P. Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog. 2 (2006) e63
18. Schweizer A., Rupp S., Taylor B.N., Rollinghoff M., and Schroppel K. The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Mol. Microbiol. 38 (2000) 435-445
19. Lo H.J., Kohler J.R., DiDomenico B., Loebenberg D., Cacciapuoti A., and Fink G.R. Nonfilamentous C. albicans mutants are avirulent. Cell 90 (1997) 939-949
20. An H.S., Lee K.H., and Kim J. Identification of an exoribonuclease homolog, CaKEM1/ CaXRN1, in Candida albicans and its characterization in filamentous growth. FEMS Microbiol. Lett. 235 (2004) 297-303
21. Gillum A.M., Tsay E.Y., and Kirsch D.R. Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae Ura3 and E. coli PyrF mutations. Mol. Gen. Genet. 198 (1984) 179-182
22. Wilson R.B., Davis D., and Mitchell A.P. Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol. 181 (1999) 1868-1874
23. Davis D., Edwards Jr. J.E., Mitchell A.P., and Ibrahim A.S. Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect. Immun. 68 (2000) 5953-5959
24. Davis D.A., Bruno V.M., Loza L., Filler S.G., and Mitchell A.P. Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis. Genetics 162 (2002) 1573-1581