메뉴 건너뛰기




Volumn 3, Issue 3, 2010, Pages 267-280

Strategies for the real-time detection of Ca2+ channel events of single cells: Recent advances and new possibilities

Author keywords

Ca2+ channel; Fluorescent probes; Intracellular Ca2+; Lab on a chip; Microfluidics; Patch clamp; Real time kinetics; Single cell analysis; Whole cell recording

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; VOLTAGE GATED CALCIUM CHANNEL;

EID: 77952565662     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/ecp.10.16     Document Type: Review
Times cited : (10)

References (136)
  • 1
    • 33846474121 scopus 로고    scopus 로고
    • G-proteincoupled receptors and cancer
    • Dorsam RT, Gutkind JS. G-proteincoupled receptors and cancer. Nat. Rev. Cancer 7 (2), 79-94 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.2 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 3
    • 0035283073 scopus 로고    scopus 로고
    • Orphan G-protein-coupled receptors and natural ligand discovery
    • Howard AD, McAllister G, Feighner SD et al. Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol. Sci. 22 (3), 132-140 (2001).
    • (2001) Trends Pharmacol. Sci. , vol.22 , Issue.3 , pp. 132-140
    • Howard, A.D.1    McAllister, G.2    Feighner, S.D.3
  • 6
    • 0036452735 scopus 로고    scopus 로고
    • An industrial perspective on utilizing functional ion channel assays for high throughput screening
    • Worley JF 3rd, Main MJ. An industrial perspective on utilizing functional ion channel assays for high throughput screening. Receptors Channels 8 (5-6), 269-282 (2002).
    • (2002) Receptors Channels , vol.8 , Issue.5-6 , pp. 269-282
    • Worley III, J.F.1    Main, M.J.2
  • 7
    • 0033830548 scopus 로고    scopus 로고
    • Abnormal intracellular Ca (2+) homeostasis and disease
    • Missiaen L, Robberecht W, van den Bosch L et al. Abnormal intracellular Ca (2+) homeostasis and disease. Cell Calcium 28 (1), 1-21 (2000).
    • (2000) Cell. Calcium , vol.28 , Issue.1 , pp. 1-21
    • Missiaen, L.1    Robberecht, W.2    Van Den Bosch, L.3
  • 8
    • 0022556251 scopus 로고
    • Cytotoxicity of phenazine methosulfate in isolated rat hepatocytes is associated with superoxide anion production, thiol oxidation and alterations in intracellular calcium ion homeostasis
    • Maridonneau-Parini I, Mirabelli F, Richelmi P, Bellomo G. Cytotoxicity of phenazine methosulfate in isolated rat hepatocytes is associated with superoxide anion production, thiol oxidation and alterations in intracellular calcium ion homeostasis. Toxicology Lett. 31 (2), 175-181 (1986).
    • (1986) Toxicology Lett. , vol.31 , Issue.2 , pp. 175-181
    • Maridonneau-Parini, I.1    Mirabelli, F.2    Richelmi, P.3    Bellomo, G.4
  • 9
    • 33747599910 scopus 로고    scopus 로고
    • 2+ and Na+ regulation in normal and failing hearts
    • 2+ and Na+ regulation in normal and failing hearts. J. Pharmacologic. Sci. 100 (5), 315-322 (2006).
    • (2006) J. Pharmacologic. Sci. , vol.100 , Issue.5 , pp. 315-322
    • Bers, D.M.1    Despa, S.2
  • 11
    • 0004122931 scopus 로고    scopus 로고
    • Saunders College Publishing, New York, NY, USA
    • Garrett RH, Grisham CM. Biochemistry. Saunders College Publishing, New York, NY, USA, 540-561 (1999).
    • (1999) Biochemistry. , pp. 540-561
    • Garrett, R.H.1    Grisham, C.M.2
  • 12
    • 33845296446 scopus 로고    scopus 로고
    • Altered cardiac myocyte Ca regulation in heart failure
    • Bers DM. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda) 21, 380-387 (2006).
    • (2006) Physiology (Bethesda) , vol.21 , pp. 380-387
    • Bers, D.M.1
  • 13
    • 0034683082 scopus 로고    scopus 로고
    • Calcium fluxes involved in control of cardiac myocyte contraction
    • Bers DM. Calcium fluxes involved in control of cardiac myocyte contraction. Circ. Res 87 (4), 275-281 (2000).
    • (2000) Circ. Res. , vol.87 , Issue.4 , pp. 275-281
    • Bers, D.M.1
  • 14
    • 33751564999 scopus 로고    scopus 로고
    • 2+ entry channels
    • 2+ entry channels. J. Cell. Biochem. 99 (6), 1503-1516 (2006).
    • (2006) J. Cell. Biochem. , vol.99 , Issue.6 , pp. 1503-1516
    • Chakrabarti, R.1
  • 15
    • 7744242400 scopus 로고    scopus 로고
    • Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: The causative role of calcium
    • Jow GM, Chou CJ, Chen BF, Tsai JH. Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: the causative role of calcium. Cancer Lett. 216 (2), 165-173 (2004).
    • (2004) Cancer Lett. , vol.216 , Issue.2 , pp. 165-173
    • Jow, G.M.1    Chou, C.J.2    Chen, B.F.3    Tsai, J.H.4
  • 16
    • 0027436464 scopus 로고
    • Intracellular calcium mediates the cytotoxicity of lipid A in LLC-PK1 cells
    • Mayeux PR, Shah SV. Intracellular calcium mediates the cytotoxicity of lipid A in LLC-PK1 cells. J. Pharmacol. Exp. Ther. 266 (1), 47-51 (1993).
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , Issue.1 , pp. 47-51
    • Mayeux, P.R.1    Shah, S.V.2
  • 17
    • 0032833924 scopus 로고    scopus 로고
    • Requirement of intracellular calcium mobilization for peroxynitrite-induced poly (ADP-ribose) synthetase activation and cytotoxicity
    • Virag L, Scott GS, Antal-Szalmas P, O'Connor M, Ohshima H, Szabo C. Requirement of intracellular calcium mobilization for peroxynitrite-induced poly (ADP-ribose) synthetase activation and cytotoxicity. Mol. Pharmacol. 56 (4), 824-833 (1999).
    • (1999) Mol. Pharmacol. , vol.56 , Issue.4 , pp. 824-833
    • Virag, L.1    Scott, G.S.2    Antal-Szalmas, P.3    O'Connor, M.4    Ohshima, H.5    Szabo, C.6
  • 18
    • 0030872625 scopus 로고    scopus 로고
    • Acanthamoeba castellanii metabolites increase the intracellular calcium level and cause cytotoxicity in wish cells
    • Mattana A, Bennardini F, Usai S, Fiori PL, Franconi F, Cappuccinelli P. Acanthamoeba castellanii metabolites increase the intracellular calcium level and cause cytotoxicity in wish cells. Microb. Pathog. 23 (2), 85-93 (1997).
    • (1997) Microb. Pathog. , vol.23 , Issue.2 , pp. 85-93
    • Mattana, A.1    Bennardini, F.2    Usai, S.3    Fiori, P.L.4    Franconi, F.5    Cappuccinelli, P.6
  • 19
    • 0028143317 scopus 로고
    • The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin
    • Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res. 54 (23), 6167-6175 (1994).
    • (1994) Cancer Res. , vol.54 , Issue.23 , pp. 6167-6175
    • Furuya, Y.1    Lundmo, P.2    Short, A.D.3    Gill, D.L.4    Isaacs, J.T.5
  • 22
    • 0027340729 scopus 로고
    • 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria
    • 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science (NY) 262 (5134), 744-747 (1993).
    • (1993) Science (NY) , vol.262 , Issue.5134 , pp. 744-747
    • Rizzuto, R.1    Brini, M.2    Murgia, M.3    Pozzan, T.4
  • 23
    • 0027340387 scopus 로고
    • 2+ to supramicromolar levels in a pancreatic β-cell line. Possible role in glucose and agonistinduced insulin secretion
    • 2+ to supramicromolar levels in a pancreatic β-cell line. Possible role in glucose and agonistinduced insulin secretion. J. Biol. Chem. 268 (30), 22385-22390 (1993).
    • (1993) J. Biol. Chem. , vol.268 , Issue.30 , pp. 22385-22390
    • Rutter, G.A.1    Theler, J.M.2    Murgia, M.3    Wollheim, C.B.4    Pozzan, T.5    Rizzuto, R.6
  • 24
    • 0344825875 scopus 로고    scopus 로고
    • Cytochrome c binds to inositol (1, 4, 5) trisphosphate receptors, amplifying calcium-dependent apoptosis
    • Boehning D, Patterson RL, Sedaghat L, Glebova NO, Kurosaki T, Snyder SH. Cytochrome c binds to inositol (1, 4, 5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat. Cell Biol. 5 (12), 1051-1061 (2003).
    • (2003) Nat. Cell. Biol. , vol.5 , Issue.12 , pp. 1051-1061
    • Boehning, D.1    Patterson, R.L.2    Sedaghat, L.3    Glebova, N.O.4    Kurosaki, T.5    Snyder, S.H.6
  • 25
    • 0034668833 scopus 로고    scopus 로고
    • Mitochondria and calcium: From cell signalling to cell death
    • Pt
    • Duchen MR. Mitochondria and calcium: from cell signalling to cell death. J. Physiol. 529 (Pt 1), 57-68 (2000).
    • (2000) J. Physiol. , vol.529 , Issue.1 , pp. 57-68
    • Duchen, M.R.1
  • 26
    • 32244436232 scopus 로고    scopus 로고
    • Mitochondria: A target for cancer therapy
    • Armstrong JS. Mitochondria: a target for cancer therapy. Br. J. Pharmacol. 147 (3), 239-248 (2006).
    • (2006) Br. J. Pharmacol. , vol.147 , Issue.3 , pp. 239-248
    • Armstrong, J.S.1
  • 27
    • 33749178260 scopus 로고    scopus 로고
    • Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
    • Festjens N, Vanden Berghe T, Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim. Biophys. Acta 1757 (9-10), 1371-1387 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1757 , Issue.9-10 , pp. 1371-1387
    • Festjens, N.1    Berghe, T.V.2    Vandenabeele, P.3
  • 28
    • 33748324499 scopus 로고    scopus 로고
    • Correlation between oxidative stress and alteration of intracellular calcium handling in isoproterenol-induced myocardial infarction
    • Diaz-Munoz M, Alvarez-Perez MA, Yanez L et al. Correlation between oxidative stress and alteration of intracellular calcium handling in isoproterenol-induced myocardial infarction. Mol. Cell Biochem. 289 (1-2), 125-136 (2006).
    • (2006) Mol. Cell. Biochem. , vol.289 , Issue.1-2 , pp. 125-136
    • Diaz-Munoz, M.1    Alvarez-Perez, M.A.2    Yanez, L.3
  • 30
    • 0036877142 scopus 로고    scopus 로고
    • The endoplasmic reticulum: A multifunctional signaling organelle
    • Berridge MJ. The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 32 (5-6), 235-249 (2002).
    • (2002) Cell. Calcium , vol.32 , Issue.5-6 , pp. 235-249
    • Berridge, M.J.1
  • 31
    • 0025998995 scopus 로고
    • Intracellular calcium changes associated with in vitro lymphokine-activated killer and natural killer cell cytotoxicity
    • Burkey BB, Omann GM, Wolf GT. Intracellular calcium changes associated with in vitro lymphokine-activated killer and natural killer cell cytotoxicity. Arch. Otolaryngol. Head Neck Surg. 117 (11), 1281-1286 (1991).
    • (1991) Arch. Otolaryngol. Head Neck Surg. , vol.117 , Issue.11 , pp. 1281-1286
    • Burkey, B.B.1    Omann, G.M.2    Wolf, G.T.3
  • 32
    • 0025883509 scopus 로고
    • Tumor necrosis factor-α stimulates prolactin release from anterior pituitary cells: A possible involvement of intracellular calcium mobilization
    • Koike K, Masumoto N, Kasahara K et al. Tumor necrosis factor-α stimulates prolactin release from anterior pituitary cells: a possible involvement of intracellular calcium mobilization. Endocrinology 128 (6), 2785-2790 (1991).
    • (1991) Endocrinology , vol.128 , Issue.6 , pp. 2785-2790
    • Koike, K.1    Masumoto, N.2    Kasahara, K.3
  • 33
    • 0037199964 scopus 로고    scopus 로고
    • Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins
    • Hurne AM, Chai CL, Moerman K, Waring P. Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins. J. Biol. Chem. 277 (35), 31631-31638 (2002).
    • (2002) J. Biol. Chem. , vol.277 , Issue.35 , pp. 31631-31638
    • Hurne, A.M.1    Chai, C.L.2    Moerman, K.3    Waring, P.4
  • 34
    • 30644474893 scopus 로고    scopus 로고
    • Pharmacogenetics and cardiac ion channels
    • Roepke TK, Abbott GW. Pharmacogenetics and cardiac ion channels. Vascul. Pharmacol. 44 (2), 90-106 (2006).
    • (2006) Vascul. Pharmacol. , vol.44 , Issue.2 , pp. 90-106
    • Roepke, T.K.1    Abbott, G.W.2
  • 35
    • 4344613647 scopus 로고    scopus 로고
    • The patch clamp technique in ion channel research
    • Jurkat-Rott K, Lehmann-Horn F. The patch clamp technique in ion channel research. Curr. Pharm. Biotechnol. 5 (4), 387-395 (2004).
    • (2004) Curr. Pharm. Biotechnol. , vol.5 , Issue.4 , pp. 387-395
    • Jurkat-Rott, K.1    Lehmann-Horn, F.2
  • 39
    • 33847729959 scopus 로고    scopus 로고
    • Using polarizationshaped optical vortex traps for single-cell nanosurgery
    • Jeffries GD, Edgar JS, Zhao Y, Shelby JP, Fong C, Chiu DT. Using polarizationshaped optical vortex traps for single-cell nanosurgery. Nano Lett. 7 (2), 415-420 (2007).
    • (2007) Nano Lett. , vol.7 , Issue.2 , pp. 415-420
    • Jeffries, G.D.1    Edgar, J.S.2    Zhao, Y.3    Shelby, J.P.4    Fong, C.5    Chiu, D.T.6
  • 40
    • 77952569722 scopus 로고    scopus 로고
    • SASCA tackles single drug-resistant cancer cells
    • Mukhopadhyay R. SASCA tackles single drug-resistant cancer cells. Anal. Chem. 80, 3951 (2008).
    • (2008) Anal. Chem. , vol.80 , pp. 3951
    • Mukhopadhyay, R.1
  • 41
    • 44949119668 scopus 로고    scopus 로고
    • Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip
    • Li XJ, Ling V, Li PCH. Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip. Anal. Chem. 80 (11), 4095-4102 (2008).
    • (2008) Anal. Chem. , vol.80 , Issue.11 , pp. 4095-4102
    • Li, X.J.1    Ling, V.2    Li, P.C.H.3
  • 43
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260 (6), 3440-3450 (1985).
    • (1985) J. Biol. Chem. , vol.260 , Issue.6 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 44
    • 0024336003 scopus 로고
    • Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores
    • Minta A, Kao JP, Tsien RY. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J. Biol. Chem. 264 (14), 8171-8178 (1989).
    • (1989) J. Biol. Chem. , vol.264 , Issue.14 , pp. 8171-8178
    • Minta, A.1    Kao, J.P.2    Tsien, R.Y.3
  • 46
    • 84904992053 scopus 로고    scopus 로고
    • Fluorescent calcium indicators based on BAPTA
    • Putney JW Jr Ed.. CRC Taylor and Francis, NY, USA
    • Poenie M. Fluorescent calcium indicators based on BAPTA. In: Calcium Signaling. Putney JW Jr (Ed.). CRC Taylor and Francis, NY, USA, 1-50 (2006).
    • (2006) Calcium Signaling. , pp. 1-50
    • Poenie, M.1
  • 49
    • 1542493288 scopus 로고    scopus 로고
    • Evaluation of FLIPR calcium 3 assay kit - A new no-wash fluorescence calcium indicator reagent
    • Zhang Y, Kowal D, Kramer A, Dunlop J. Evaluation of FLIPR calcium 3 assay kit - a new no-wash fluorescence calcium indicator reagent. J. Biomol. Screen. 8 (5), 571-577 (2003).
    • (2003) J. Biomol. Screen. , vol.8 , Issue.5 , pp. 571-577
    • Zhang, Y.1    Kowal, D.2    Kramer, A.3    Dunlop, J.4
  • 50
    • 0037228849 scopus 로고    scopus 로고
    • No-wash dyes for calcium flux measurement
    • Mehlin C, Crittenden C, Andreyka J. No-wash dyes for calcium flux measurement. Biotechniques, 34 (1), 164-166 (2003).
    • (2003) Biotechniques , vol.34 , Issue.1 , pp. 164-166
    • Mehlin, C.1    Crittenden, C.2    Andreyka, J.3
  • 51
    • 33845782385 scopus 로고    scopus 로고
    • 2+ indicators: Using genetics and molecular design to understand complex physiology
    • Pt
    • 2+ indicators: using genetics and molecular design to understand complex physiology. J. Physiol. 578 (Pt 1), 55-67 (2007).
    • (2007) J. Physiol. , vol.578 , Issue.1 , pp. 55-67
    • Kotlikoff, M.I.1
  • 52
    • 77952560777 scopus 로고    scopus 로고
    • Genetically encoded fluorescent calcium indicator proteins
    • Putney JW Jr Ed.. CRC Taylor and Francis group, NY, USA
    • Miyawaki A, Nagai T, Mizuno H. Genetically encoded fluorescent calcium indicator proteins. In: Calcium Signaling. Putney JW Jr (Ed.). CRC Taylor and Francis group, NY, USA, 101-111 (2006).
    • (2006) Calcium Signaling. , pp. 101-111
    • Miyawaki, A.1    Nagai, T.2    Mizuno, H.3
  • 53
    • 0342333575 scopus 로고
    • Cloning and sequence analysis of cDNA for the luminescent protein aequorin
    • Inouye S, Noguchi M, Sakaki Y et al. Cloning and sequence analysis of cDNA for the luminescent protein aequorin. Proc. Natl Acad. Sci. USA 82 (10), 3154-3158 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , Issue.10 , pp. 3154-3158
    • Inouye, S.1    Noguchi, M.2    Sakaki, Y.3
  • 54
    • 5544273772 scopus 로고    scopus 로고
    • Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments
    • Missiaen L, Van Acker K, Van Baelen K et al. Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments. Cell Calcium 36 (6), 479-487 (2004).
    • (2004) Cell. Calcium , vol.36 , Issue.6 , pp. 479-487
    • Missiaen, L.1    Van Acker, K.2    Van Baelen, K.3
  • 56
    • 77952557087 scopus 로고    scopus 로고
    • Targeted aequorins
    • Putney JW Jr Ed.. CRC Taylor & Francis, NY, USA
    • Prandini A, Rizutto R. Targeted Aequorins. In: Calcium Signaling. Putney JW Jr (Ed.). CRC Taylor & Francis, NY, USA, 113-124 (2006).
    • (2006) Calcium Signaling. , pp. 113-124
    • Prandini, A.1    Rizutto, R.2
  • 57
    • 0035129282 scopus 로고    scopus 로고
    • 2+) probe composed of a single green fluorescent protein
    • 2+) probe composed of a single green fluorescent protein. Nat. Biotechnol. 19 (2), 137-141 (2001).
    • (2001) Nat. Biotechnol. , vol.19 , Issue.2 , pp. 137-141
    • Nakai, J.1    Ohkura, M.2    Imoto, K.3
  • 58
    • 46349085255 scopus 로고    scopus 로고
    • Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators
    • Mao T, O'Connor DH, Scheuss V, Nakai J, Svoboda K. Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators. PLoS ONE 3 (3), e1796 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.3
    • Mao, T.1    O'Connor, D.H.2    Scheuss, V.3    Nakai, J.4    Svoboda, K.5
  • 59
    • 49749136198 scopus 로고    scopus 로고
    • A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulum
    • Rehberg M, Lepier A, Solchenberger B, Osten P, Blum R. A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulum. Cell Calcium 44 (4), 386-399 (2008).
    • (2008) Cell. Calcium , vol.44 , Issue.4 , pp. 386-399
    • Rehberg, M.1    Lepier, A.2    Solchenberger, B.3    Osten, P.4    Blum, R.5
  • 64
    • 0347134477 scopus 로고    scopus 로고
    • Microfluidic devices fabricated in poly (dimethylsiloxane) for biological studies
    • Sia SK, Whitesides GM. Microfluidic devices fabricated in poly (dimethylsiloxane) for biological studies. Electrophoresis 24 (21), 3563-3576 (2003).
    • (2003) Electrophoresis , vol.24 , Issue.21 , pp. 3563-3576
    • Sia, S.K.1    Whitesides, G.M.2
  • 65
    • 4544263876 scopus 로고    scopus 로고
    • A three-dimensional flow control concept for single-cell experiments on a microchip. 1. Cell selection, cell retention, cell culture, cell balancing, and cell scanning
    • Peng XY, Li PCH. A three-dimensional flow control concept for single-cell experiments on a microchip. 1. Cell selection, cell retention, cell culture, cell balancing, and cell scanning. Anal. Chem. 76 (18), 5273-5281 (2004).
    • (2004) Anal. Chem. , vol.76 , Issue.18 , pp. 5273-5281
    • Peng, X.Y.1    Li, P.C.H.2
  • 66
    • 4544383117 scopus 로고    scopus 로고
    • A three-dimensional flow control concept for single-cell experiments on a microchip. 2. Fluorescein diacetate metabolism and calcium mobilization in a single yeast cell as stimulated by glucose and pH changes
    • Peng XY, Li PC. A three-dimensional flow control concept for single-cell experiments on a microchip. 2. Fluorescein diacetate metabolism and calcium mobilization in a single yeast cell as stimulated by glucose and pH changes. Anal. Chem. 76 (18), 5282-5292 (2004).
    • (2004) Anal. Chem. , vol.76 , Issue.18 , pp. 5282-5292
    • Peng, X.Y.1    Li, P.C.2
  • 67
    • 0242586122 scopus 로고    scopus 로고
    • Microfluidic device for single-cell analysis
    • Wheeler AR, Throndset WR, Whelan RJ et al. Microfluidic device for single-cell analysis. Anal. Chem. 75 (14), 3581-3586 (2003).
    • (2003) Anal. Chem. , vol.75 , Issue.14 , pp. 3581-3586
    • Wheeler, A.R.1    Throndset, W.R.2    Whelan, R.J.3
  • 69
    • 27544510749 scopus 로고    scopus 로고
    • Microfluidic selection and retention of a single cardiac myocyte, on-chip dye loading, cell contraction by chemical stimulation, and quantitative fluorescent analysis of intracellular calcium
    • Li XJ, Li PCH. Microfluidic selection and retention of a single cardiac myocyte, on-chip dye loading, cell contraction by chemical stimulation, and quantitative fluorescent analysis of intracellular calcium. Anal. Chem. 77 (14), 4315-4322 (2005).
    • (2005) Anal. Chem. , vol.77 , Issue.14 , pp. 4315-4322
    • Li, X.J.1    Li, P.C.H.2
  • 70
    • 60549084955 scopus 로고    scopus 로고
    • Contraction study of a single cardiac muscle cell in a microfluidic chip
    • Li XJ, Li PCH. Contraction study of a single cardiac muscle cell in a microfluidic chip. Methods Mol. Biol. 321, 199-225 (2006).
    • (2006) Methods Mol. Biol. , vol.321 , pp. 199-225
    • Li, X.J.1    Li, P.C.H.2
  • 71
    • 77949314572 scopus 로고    scopus 로고
    • Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip
    • Li XJ, Xue X, Li PCH. Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip. Integr. Biol. 1 (1), 90-98 (2009).
    • (2009) Integr. Biol. , vol.1 , Issue.1 , pp. 90-98
    • Li, X.J.1    Xue, X.2    Li, P.C.H.3
  • 72
    • 0346710425 scopus 로고    scopus 로고
    • Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows
    • Kaji H, Nishizawa M, Matsue T. Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows. Lab On A Chip 3 (3), 208-211 (2003).
    • (2003) Lab. on a Chip , vol.3 , Issue.3 , pp. 208-211
    • Kaji, H.1    Nishizawa, M.2    Matsue, T.3
  • 73
    • 37549009490 scopus 로고    scopus 로고
    • Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery
    • Li XJ, Huang J, Tibbits GF, Li PCH. Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery. Electrophoresis 28 (24), 4723-4733 (2007).
    • (2007) Electrophoresis , vol.28 , Issue.24 , pp. 4723-4733
    • Li, X.J.1    Huang, J.2    Tibbits, G.F.3    Li, P.C.H.4
  • 74
    • 0042823497 scopus 로고    scopus 로고
    • Stimulation of single isolated adult ventricular myocytes within a low volume using a planar microelectrode array
    • Klauke N, Smith GL, Cooper J. Stimulation of single isolated adult ventricular myocytes within a low volume using a planar microelectrode array. Biophys. J. 85 (3), 1766-1774 (2003).
    • (2003) Biophys. J. , vol.85 , Issue.3 , pp. 1766-1774
    • Klauke, N.1    Smith, G.L.2    Cooper, J.3
  • 75
    • 14844286513 scopus 로고    scopus 로고
    • Stimulation of isolated ventricular myocytes within an open architecture microarray
    • Klauke N, Smith GL, Cooper JM. Stimulation of isolated ventricular myocytes within an open architecture microarray. IEEE Transactions Biomed. Engineer. 52 (3), 531-538 (2005).
    • (2005) IEEE Transactions Biomed. Engineer. , vol.52 , Issue.3 , pp. 531-538
    • Klauke, N.1    Smith, G.L.2    Cooper, J.M.3
  • 76
    • 33749450026 scopus 로고    scopus 로고
    • Extracellular recordings of field potentials from single cardiomyocytes
    • Klauke N, Smith GL, Cooper J. Extracellular recordings of field potentials from single cardiomyocytes. Biophys. J. 91 (7), 2543-2551 (2006).
    • (2006) Biophys. J. , vol.91 , Issue.7 , pp. 2543-2551
    • Klauke, N.1    Smith, G.L.2    Cooper, J.3
  • 77
    • 33750447943 scopus 로고    scopus 로고
    • Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform
    • Cheng W, Klauke N, Sedgwick H, Smith GL, Cooper JM. Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. Lab On A Chip 6 (11), 1424-1431 (2006).
    • (2006) Lab. on a Chip , vol.6 , Issue.11 , pp. 1424-1431
    • Cheng, W.1    Klauke, N.2    Sedgwick, H.3    Smith, G.L.4    Cooper, J.M.5
  • 78
    • 34249800649 scopus 로고    scopus 로고
    • Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes
    • Klauke N, Smith G, Cooper JM. Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. Lab On A Chip 7 (6), 731-739 (2007).
    • (2007) Lab. on a Chip , vol.7 , Issue.6 , pp. 731-739
    • Klauke, N.1    Smith, G.2    Cooper, J.M.3
  • 79
    • 15544368216 scopus 로고    scopus 로고
    • Store-operated calcium channels
    • Parekh AB, Putney J W, Jr. Store-operated calcium channels. Physiological Rev. 85 (2), 757-810 (2005).
    • (2005) Physiological Rev. , vol.85 , Issue.2 , pp. 757-810
    • Parekh, A.B.1    Putney Jr., J.W.2
  • 80
    • 77952575062 scopus 로고    scopus 로고
    • 2+ currents
    • Putney JW Jr Ed.. CRC Taylor & Francis, NY, USA
    • 2+ currents. In: Calcium Signaling Putney JW Jr (Ed.). CRC Taylor & Francis, NY, USA, 125-146 (2006).
    • (2006) Calcium Signaling , pp. 125-146
    • Parekh, A.B.1
  • 81
    • 33644845080 scopus 로고    scopus 로고
    • 2+ channel currents heterologous expression systems and dissociated brain neurons
    • 2+ channel currents heterologous expression systems and dissociated brain neurons. Methods Mol. Biol. 312, 161-179 (2006).
    • (2006) Methods Mol. Biol. , vol.312 , pp. 161-179
    • Hainsworth, A.H.1    Randall, A.D.2    Stefani, A.3
  • 83
    • 0035866658 scopus 로고    scopus 로고
    • Screening of ion channel receptor agonists using capillary electrophoresis-patch clamp detection with resensitized detector cells
    • Farre C, Sjoberg A, Jardemark K, Jacobson I, Orwar O. Screening of ion channel receptor agonists using capillary electrophoresis-patch clamp detection with resensitized detector cells. Anal. Chem. 73 (6), 1228-1233 (2001).
    • (2001) Anal. Chem. , vol.73 , Issue.6 , pp. 1228-1233
    • Farre, C.1    Sjoberg, A.2    Jardemark, K.3    Jacobson, I.4    Orwar, O.5
  • 84
    • 73349102538 scopus 로고    scopus 로고
    • Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: A patch clamp study
    • Ziegler E, Bodusch M, Song Y et al. Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Naunyn Schmiedebergs Arch. Pharmacol. 380 (4), 277-291 (2009).
    • (2009) Naunyn Schmiedebergs Arch. Pharmacol. , vol.380 , Issue.4 , pp. 277-291
    • Ziegler, E.1    Bodusch, M.2    Song, Y.3
  • 85
    • 70649101232 scopus 로고    scopus 로고
    • v) 3.1 (α (1G)) T-type calcium channels by the antipsychotic drug clozapine
    • v) 3.1 (α (1G)) T-type calcium channels by the antipsychotic drug clozapine. Eur. J. Pharmacol. 626 (2-3), 123-130 (2009).
    • (2009) Eur. J. Pharmacol. , vol.626 , Issue.2-3 , pp. 123-130
    • Choi, K.H.1    Rhim, H.2
  • 86
    • 61449223525 scopus 로고    scopus 로고
    • Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels
    • Parnas M, Peters M, Dadon D et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 45 (3), 300-309 (2009).
    • (2009) Cell. Calcium , vol.45 , Issue.3 , pp. 300-309
    • Parnas, M.1    Peters, M.2    Dadon, D.3
  • 87
    • 70149105270 scopus 로고    scopus 로고
    • Impact of dihydrotestosterone on L-type calcium channels in human ventricular cardiomyocytes
    • Er F, Gassanov N, Brandt MC, Madershahian N, Hoppe UC. Impact of dihydrotestosterone on L-type calcium channels in human ventricular cardiomyocytes. Endocr. Res. 34 (3), 59-67 (2009).
    • (2009) Endocr. Res. , vol.34 , Issue.3 , pp. 59-67
    • Er, F.1    Gassanov, N.2    Brandt, M.C.3    Madershahian, N.4    Hoppe, U.C.5
  • 88
    • 65949108391 scopus 로고    scopus 로고
    • Coriaria lactone increased the intracellular level of calcium through the voltage-gated calcium channels in rat hippocampal neurons
    • Zhang Q, Lai X, Liao D, Stefan H, Zhou D. Coriaria lactone increased the intracellular level of calcium through the voltage-gated calcium channels in rat hippocampal neurons. Neurochem. Res. 34 (7), 1332-1342 (2009).
    • (2009) Neurochem. Res. , vol.34 , Issue.7 , pp. 1332-1342
    • Zhang, Q.1    Lai, X.2    Liao, D.3    Stefan, H.4    Zhou, D.5
  • 89
    • 52049108693 scopus 로고    scopus 로고
    • 2+) channel in guinea pig gallbladder smooth muscle
    • 2+) channel in guinea pig gallbladder smooth muscle. Eur. J. Pharmacol. 595 (1-3), 95-99 (2008).
    • (2008) Eur. J. Pharmacol. , vol.595 , Issue.1-3 , pp. 95-99
    • Wu, Z.X.1    Yu, B.P.2    Xia, H.3    Xu, L.4
  • 90
    • 0036106307 scopus 로고    scopus 로고
    • Whole cell patch clamp recording performed on a planar glass chip
    • Fertig N, Blick RH, Behrends JC. Whole cell patch clamp recording performed on a planar glass chip. Biophys. J. 82 (6), 3056-3062 (2002).
    • (2002) Biophys. J. , vol.82 , Issue.6 , pp. 3056-3062
    • Fertig, N.1    Blick, R.H.2    Behrends, J.C.3
  • 91
    • 0037449319 scopus 로고    scopus 로고
    • Activity of single ion channel proteins detected with a planar microstructure
    • Fertig N, Klau M, George M, Blick RH, Behrends JC. Activity of single ion channel proteins detected with a planar microstructure. Appl. Phys. Lett. 81, 4865-4867 (2002).
    • (2002) Appl. Phys. Lett. , vol.81 , pp. 4865-4867
    • Fertig, N.1    Klau, M.2    George, M.3    Blick, R.H.4    Behrends, J.C.5
  • 92
    • 59849100915 scopus 로고    scopus 로고
    • Robotic multiwell planar patch-clamp for native and primary mammalian cells
    • Milligan CJ, Li J, Sukumar P et al. Robotic multiwell planar patch-clamp for native and primary mammalian cells. Nat. Protoc. 4 (2), 244-255 (2009).
    • (2009) Nat. Protoc. , vol.4 , Issue.2 , pp. 244-255
    • Milligan, C.J.1    Li, J.2    Sukumar, P.3
  • 93
    • 0037178198 scopus 로고    scopus 로고
    • Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells
    • Klemic KG, Klemic JF, Reed MA, Sigworth FJ. Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells. Biosensors Bioelectronics 17 (6-7), 597-604 (2002).
    • (2002) Biosensors Bioelectronics , vol.17 , Issue.6-7 , pp. 597-604
    • Klemic, K.G.1    Klemic, J.F.2    Reed, M.A.3    Sigworth, F.J.4
  • 94
    • 17444400816 scopus 로고    scopus 로고
    • An air-molding technique for fabricating PDMS planar patch-clamp electrodes
    • Klemic KG, Klemic JF, Sigworth FJ. An air-molding technique for fabricating PDMS planar patch-clamp electrodes. Pflugers Arch. 449 (6), 564-572 (2005).
    • (2005) Pflugers Arch. , vol.449 , Issue.6 , pp. 564-572
    • Klemic, K.G.1    Klemic, J.F.2    Sigworth, F.J.3
  • 95
    • 33646407847 scopus 로고    scopus 로고
    • Microfluidic system for planar patch clamp electrode arrays
    • Li X, Klemic KG, Reed MA, Sigworth FJ. Microfluidic system for planar patch clamp electrode arrays. Nano Lett. 6 (4), 815-819 (2006).
    • (2006) Nano Lett. , vol.6 , Issue.4 , pp. 815-819
    • Li, X.1    Klemic, K.G.2    Reed, M.A.3    Sigworth, F.J.4
  • 97
    • 1942433697 scopus 로고    scopus 로고
    • A benchmark study with sealchip planar patch-clamp technology
    • Xu J, Guia A, Rothwarf D et al. A benchmark study with sealchip planar patch-clamp technology. Assay Drug Dev. Technol. 1 (5), 675-684 (2003).
    • (2003) Assay Drug Dev. Technol. , vol.1 , Issue.5 , pp. 675-684
    • Xu, J.1    Guia, A.2    Rothwarf, D.3
  • 98
    • 41149144182 scopus 로고    scopus 로고
    • Planar patch clamping
    • Patch Clamp Analysis: Advanced Techniques, Walz W Ed.. Humana Press, NY, USA
    • Behrends JC, Fertig N. Planar patch clamping. In: Neromethods Volume 38. Patch Clamp Analysis: Advanced Techniques. Walz W (Ed.). Humana Press, NY, USA, 414-433 (2007).
    • (2007) Neromethods Volume 38. , pp. 414-433
    • Behrends, J.C.1    Fertig, N.2
  • 99
    • 33645780149 scopus 로고    scopus 로고
    • QPatch: The past, present and future of automated patch clamp
    • Mathes C. QPatch: the past, present and future of automated patch clamp. Expert Opin. Ther. Targets 10 (2), 319-327 (2006).
    • (2006) Expert Opin. Ther. Targets , vol.10 , Issue.2 , pp. 319-327
    • Mathes, C.1
  • 100
    • 20144389310 scopus 로고    scopus 로고
    • Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp
    • Dubin AE, Nasser N, Rohrbacher J et al. Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp. J. Biomol. Screen 10 (2), 168-181 (2005).
    • (2005) J. Biomol. Screen , vol.10 , Issue.2 , pp. 168-181
    • Dubin, A.E.1    Nasser, N.2    Rohrbacher, J.3
  • 101
    • 77952574793 scopus 로고    scopus 로고
    • Highthroughput electrophysiological measurement apparatus
    • Schroeder KS, Neagle BD. Highthroughput electrophysiological measurement apparatus. US Patent 6, 488 (2002)
    • (2002) US Patent , vol.6 , pp. 488
    • Schroeder, K.S.1    Neagle, B.D.2
  • 102
    • 0041888478 scopus 로고    scopus 로고
    • Ionworks HT: A new highthroughput electrophysiology measurement platform
    • Schroeder K, Neagle B, Trezise DJ, Worley J. Ionworks HT: a new highthroughput electrophysiology measurement platform. J. Biomol. Screen. 8 (1), 50-64 (2003).
    • (2003) J. Biomol. Screen. , vol.8 , Issue.1 , pp. 50-64
    • Schroeder, K.1    Neagle, B.2    Trezise, D.J.3    Worley, J.4
  • 103
    • 15244356099 scopus 로고    scopus 로고
    • Microchip technology in ion-channel research
    • Sigworth FJ, Klemic KG. Microchip technology in ion-channel research. IEEE Trans. Nanobiosci. 4 (1), 121-127 (2005).
    • (2005) IEEE Trans. Nanobiosci. , vol.4 , Issue.1 , pp. 121-127
    • Sigworth, F.J.1    Klemic, K.G.2
  • 104
    • 1942529810 scopus 로고    scopus 로고
    • Characterization of potassium channel modulators with QPatch automated patch-clamp technology: System characteristics and performance
    • Kutchinsky J, Friis S, Asmild M et al. Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance. Assay Drug Dev. Technol. 1 (5), 685-693 (2003).
    • (2003) Assay Drug Dev. Technol. , vol.1 , Issue.5 , pp. 685-693
    • Kutchinsky, J.1    Friis, S.2    Asmild, M.3
  • 105
    • 0037232042 scopus 로고    scopus 로고
    • Cytocentering: A novel technique enabling automated cell-by-cell patch clamping with the Cytopatch chip
    • Stett A, Burkhardt C, Weber U, van Stiphout P, Knott T. Cytocentering: a novel technique enabling automated cell-by-cell patch clamping with the Cytopatch chip. Receptors Channels 9 (1), 59-66 (2003).
    • (2003) Receptors Channels , vol.9 , Issue.1 , pp. 59-66
    • Stett, A.1    Burkhardt, C.2    Weber, U.3    Van Stiphout, P.4    Knott, T.5
  • 106
    • 77952558789 scopus 로고    scopus 로고
    • 3D microfluidic chip for automated patch-clamping
    • Presented at:, Freiburg, Germany, 10-12 October
    • van Stiphout P, Knott T, Danker T, Stett A. 3D microfluidic chip for automated patch-clamping. Presented at: Mikrosystemtechnik Kongress. Freiburg, Germany, 10-12 October 2005.
    • (2005) Mikrosystemtechnik Kongress.
    • Van Stiphout, P.1    Knott, T.2    Danker, T.3    Stett, A.4
  • 107
    • 33846264581 scopus 로고    scopus 로고
    • Open-access microfluidic patch-clamp array with raised lateral cell trapping sites
    • Lau AY, Hung PJ, Wu AR, Lee LP. Open-access microfluidic patch-clamp array with raised lateral cell trapping sites. Lab On A Chip 6 (12), 1510-1515 (2006).
    • (2006) Lab. on a Chip , vol.6 , Issue.12 , pp. 1510-1515
    • Lau, A.Y.1    Hung, P.J.2    Wu, A.R.3    Lee, L.P.4
  • 109
    • 33750997578 scopus 로고    scopus 로고
    • A high-performance elastomeric patch clamp chip
    • Chen C, Folch A. A high-performance elastomeric patch clamp chip. Lab On A Chip 6 (10), 1338-1345 (2006).
    • (2006) Lab. on a Chip , vol.6 , Issue.10 , pp. 1338-1345
    • Chen, C.1    Folch, A.2
  • 110
    • 0037115389 scopus 로고    scopus 로고
    • A cell-based bar code reader for highthroughput screening of ion channel-ligand interactions
    • Sinclair J, Pihl J, Olofsson J et al. A cell-based bar code reader for highthroughput screening of ion channel-ligand interactions. Anal. Chem. 74 (24), 6133-6138 (2002).
    • (2002) Anal. Chem. , vol.74 , Issue.24 , pp. 6133-6138
    • Sinclair, J.1    Pihl, J.2    Olofsson, J.3
  • 111
    • 27144487391 scopus 로고    scopus 로고
    • Microfluidic technologies in drug discovery
    • Pihl J, Karlsson M, Chiu DT. Microfluidic technologies in drug discovery. Drug Discov. Today 10 (20), 1377-1383 (2005).
    • (2005) Drug Discov. Today , vol.10 , Issue.20 , pp. 1377-1383
    • Pihl, J.1    Karlsson, M.2    Chiu, D.T.3
  • 112
    • 0037234427 scopus 로고    scopus 로고
    • Flip the tip: An automated, high quality, cost effective patch clamp screen
    • Lepple-Wienhues A. Flip the tip: an automated, high quality, cost effective patch clamp screen. Receptors Channels 9, 13-17 (2003).
    • (2003) Receptors Channels , vol.9 , pp. 13-17
    • Lepple-Wienhues, A.1
  • 117
    • 36249023612 scopus 로고    scopus 로고
    • 3) H] Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions
    • 3) H] Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions. Purinergic Signal. 3 (4), 347-358 (2007).
    • (2007) Purinergic Signal. , vol.3 , Issue.4 , pp. 347-358
    • Schiedel, A.C.1    Meyer, H.2    Alsdorf, B.B.3    Gorzalka, S.4    Brussel, H.5    Muller, C.E.6
  • 119
    • 0348230460 scopus 로고    scopus 로고
    • Screening technologies for ion channel targets in drug discovery
    • Zheng W, Kiss L. Screening technologies for ion channel targets in drug discovery. Am. Pharmaceut. Rev. 6 (4), 85-92 (2003).
    • (2003) Am. Pharmaceut. Rev. , vol.6 , Issue.4 , pp. 85-92
    • Zheng, W.1    Kiss, L.2
  • 120
    • 10244264821 scopus 로고    scopus 로고
    • High throughput assay technologies for ion channel drug discovery
    • Zheng W, Spencer RH, Kiss L. High throughput assay technologies for ion channel drug discovery. Assay Drug Dev. Technol. 2 (5), 543-552 (2004).
    • (2004) Assay Drug Dev. Technol. , vol.2 , Issue.5 , pp. 543-552
    • Zheng, W.1    Spencer, R.H.2    Kiss, L.3
  • 121
    • 33644924900 scopus 로고    scopus 로고
    • Exploiting high-throughput ion channel screening technologies in integrated drug discovery
    • Treherne JM. Exploiting high-throughput ion channel screening technologies in integrated drug discovery. Curr. Pharm. Des. 12 (4), 397-406 (2006).
    • (2006) Curr. Pharm. Des. , vol.12 , Issue.4 , pp. 397-406
    • Treherne, J.M.1
  • 123
    • 0035992008 scopus 로고    scopus 로고
    • 2+] using Oregon Green BAPTA 5N and confocal laser scanning microscopy
    • 2+] using Oregon Green BAPTA 5N and confocal laser scanning microscopy. Cell Calcium 31 (4), 151-159 (2002).
    • (2002) Cell. Calcium , vol.31 , Issue.4 , pp. 151-159
    • White, C.1    McGeown, G.2
  • 124
    • 33644843737 scopus 로고    scopus 로고
    • Confocal microscopy: Theory and applications for cellular signaling
    • Tovey SC, Brighton PJ, Willars GB. Confocal microscopy: theory and applications for cellular signaling. Methods Mol. Biol. 312, 57-85 (2006).
    • (2006) Methods Mol. Biol. , vol.312 , pp. 57-85
    • Tovey, S.C.1    Brighton, P.J.2    Willars, G.B.3
  • 125
    • 63349096430 scopus 로고    scopus 로고
    • 2+ transient is mediated by inositol 1, 4, 5-trisphosphate receptors in mouse pancreatic β-cells
    • 2+ transient is mediated by inositol 1, 4, 5-trisphosphate receptors in mouse pancreatic β-cells. Biochem. Biophys. Res. Commun. 382 (2), 381-384 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.382 , Issue.2 , pp. 381-384
    • Chen, Z.1    Li, Z.2    Peng, G.3
  • 126
    • 35748932679 scopus 로고    scopus 로고
    • Two-photon photostimulation and imaging of neural circuits
    • Nikolenko V, Poskanzer KE, Yuste R. Two-photon photostimulation and imaging of neural circuits. Nat. Methods 4 (11), 943-950 (2007).
    • (2007) Nat. Methods , vol.4 , Issue.11 , pp. 943-950
    • Nikolenko, V.1    Poskanzer, K.E.2    Yuste, R.3
  • 127
    • 33750515671 scopus 로고    scopus 로고
    • Imaging singlechannel calcium microdomains
    • Demuro A, Parker I. Imaging singlechannel calcium microdomains. Cell Calcium 40 (5-6), 413-422 (2006).
    • (2006) Cell. Calcium , vol.40 , Issue.5-6 , pp. 413-422
    • Demuro, A.1    Parker, I.2
  • 128
    • 33847696980 scopus 로고    scopus 로고
    • 2+ waves by total internal reflection fluorescence microscopy (TIRFM)
    • 2+ waves by total internal reflection fluorescence microscopy (TIRFM). Int. J. Neurosci. 5, 709-714 (2006).
    • (2006) Int. J. Neurosci. , vol.5 , pp. 709-714
    • Bai, Y.1    Tang, A.2    Wang, S.3    Zhu, X.4
  • 129
    • 52649138550 scopus 로고    scopus 로고
    • Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel
    • Faley S, Seale K, Hughey J et al. Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab On A Chip 8 (10), 1700-1712 (2008).
    • (2008) Lab. on a Chip , vol.8 , Issue.10 , pp. 1700-1712
    • Faley, S.1    Seale, K.2    Hughey, J.3
  • 130
    • 33845348652 scopus 로고    scopus 로고
    • Dynamic single-cell analysis for quantitative biology
    • Di Carlo D, Lee LP. Dynamic single-cell analysis for quantitative biology. Anal. Chem. 78 (23), 7918-7925 (2006).
    • (2006) Anal. Chem. , vol.78 , Issue.23 , pp. 7918-7925
    • Di Carlo, D.1    Lee, L.P.2
  • 131
    • 33947686032 scopus 로고    scopus 로고
    • Analysis of single mammalian cells on-chip
    • Sims CE, Allbritton NL. Analysis of single mammalian cells on-chip. Lab On A Chip 7 (4), 423-440 (2007).
    • (2007) Lab. on a Chip , vol.7 , Issue.4 , pp. 423-440
    • Sims, C.E.1    Allbritton, N.L.2
  • 132
    • 33746263955 scopus 로고    scopus 로고
    • Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays
    • Di Carlo D, Aghdam N, Lee LP. Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays. Anal. Chem. 78 (14), 4925-4930 (2006).
    • (2006) Anal. Chem. , vol.78 , Issue.14 , pp. 4925-4930
    • Di Carlo, D.1    Aghdam, N.2    Lee, L.P.3
  • 133
    • 33746578974 scopus 로고    scopus 로고
    • A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells
    • Deutsch M, Deutsch A, Shirihai O et al. A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells. Lab On A Chip 6 (8), 995-1000 (2006).
    • (2006) Lab. on a Chip , vol.6 , Issue.8 , pp. 995-1000
    • Deutsch, M.1    Deutsch, A.2    Shirihai, O.3
  • 134
    • 0035966862 scopus 로고    scopus 로고
    • 2+ channels and ryanodine receptors in heart cells
    • 2+ channels and ryanodine receptors in heart cells. Nature 410 (6828), 592-596 (2001).
    • (2001) Nature , vol.410 , Issue.6828 , pp. 592-596
    • Wang, S.Q.1    Song, L.S.2    Lakatta, E.G.3    Cheng, H.4
  • 136
    • 24344510184 scopus 로고    scopus 로고
    • 2+ flux through individual muscle acetylcholine receptor channels
    • 2+ flux through individual muscle acetylcholine receptor channels. J. Gen. Physiol. 126 (3), 179-192 (2005).
    • (2005) J. Gen. Physiol. , vol.126 , Issue.3 , pp. 179-192
    • Demuro, A.1    Parker, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.