Insufficiency Fractures After Pelvic Radiotherapy in Patients With Prostate Cancer

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 3, 2010, Pages 818-823

  Iǧdem, Şefik ^a   Alço, Gül ^b   Ercan, Tülay ^b   Barlan, Metin ^b   Ganiyusufoǧlu, Kürşat ^b   Ünalan, Bülent ^b   Turkan, Sedat ^b   Okkan, Sait ^a  

^a ISTANBUL BILIM UNIVERSITY   (Turkey)

^b Florence Nightingale Gayrettepe Hospital   (Turkey)

Author keywords

Androgen deprivation; Complication; Insufficiency fracture; Pelvic radiotherapy; Prostate cancer

Indexed keywords

ANDROGEN DEPRIVATION; CLINICAL CHARACTERISTICS; CUMULATIVE INCIDENCE; LOWER BACK PAIN; METASTATIC DISEASE; MR IMAGING; PELVIC RADIOTHERAPY; PREDISPOSING FACTORS; PROSTATE CANCERS; UP PERIOD;

BONE; COMPUTERIZED TOMOGRAPHY; FRACTURE; MAGNETIC RESONANCE IMAGING; RADIOTHERAPY;

DISEASES;

ANTIANDROGEN;

ADULT; AGED; ARTICLE; BONE METASTASIS; BONE RADIOGRAPHY; CANCER PATIENT; CANCER STAGING; CLINICAL FEATURE; COMPUTER ASSISTED RADIOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONSERVATIVE TREATMENT; DISEASE PREDISPOSITION; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LOW BACK PAIN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MORBIDITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PELVIS FRACTURE; PELVIS INSUFFICIENCY FRACTURE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; FOLLOW-UP STUDIES; FRACTURES, BONE; FRACTURES, STRESS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PELVIC PAIN; PROSTATIC NEOPLASMS; PUBIC BONE; RADIATION INJURIES; RETROSPECTIVE STUDIES; RISK FACTORS; SACRUM;

EID: 77952559792     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.05.059     Document Type: Article

References (31)

1. Cooper K.L., Beabout J.W., and Swee R.G. Insufficiency fractures of the sacrum. Radiology 156 (1985) 15-20
2. Huh S.J., Kim B., Kang M.K., et al. Pelvic insufficiency fracture after pelvic irradiation in uterine cervix cancer. Gynecol Oncol 86 (2002) 264-268
3. Konski A., and Sowers M. Pelvic fractures following irradiation for endometrial carcinoma. Int J Radiat Oncol Biol Phys 35 (1996) 361-367
4. Fi{dotless}rat S., Murray K., and Erickson B. High dose whole abdominal and pelvic irradiation for treatment of ovarian carcinoma: Long term toxicity and outcome. Int J Radiat Oncol Biol Phys 57 (2003) 201-207
5. Allal A.S., Mermillod B., Roth A.D., et al. Impact of clinical and therapeutic factors on major late complications after radiotherapy with or without concomitant chemotherapy for anal carcinoma. Int J Radiat Oncol Biol Phys 39 (1997) 1099-1105
6. Inoue Y., Miki C., Ojima E., et al. Pelvic insufficiency fractures after preoperative radiotherapy for rectal carcinoma. Int J Clin Oncol 8 (2003) 336-339
7. Beşe N.S., Özgüroǧlu M., Kamberoǧlu K., et al. Pentoxifylline in the treatment of radiation related pelvic insufficiency fractures of bone. Radiat Med 21 (2003) 223-227
8. Ogino I., Okamoto N., Ono Y., et al. Pelvic insufficiency fractures in postmenapausal women with advanced cervical cancer treated by radiotherapy. Radiother Oncol 68 (2003) 61-67
9. Ikushima H., Osaki K., Furutani S., et al. Pelvic bone complications following radiation therapy of gynecologic malignancies: Clinical evaluation of radiation induced pelvic insufficiency fractures. Gynecol Oncol 103 (2006) 1100-1104
10. Oh D., Huh S.J., Nam H., et al. Pelvic insufficiency fracture after pelvic radiotherapy for cervical cancer: Analysis of risk factors. Int J Radiat Oncol Biol Phys 70 (2008) 1183-1188
11. Ilner K., Blomlie V., and Fossa S.D. Radiation induced insufficiency fractures after definitive prostate cancer radiotherapy. Acta Oncologica 37 (1998) 201-202
12. Yokokawa T., Shirai T., Ogata H., and Furui S. Insufficiency fracture of the sacrum after hormonal therapy and radiotherapy for prostate cancer: A case in which 99mTc-MDP bone scintigraphy was useful for differential diagnosis. Kaku Igaku 42 (2005) 403-407
13. Roach III M., Marquez C., Yuo H.S., et al. Predicting the risk of lymph node involvement using the pretreatment prostate spesific antigen (PSA) and Gleason score in men with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 28 (1994) 33-37
14. Roach III M., DeSilvio M., Lawton C., et al. Phase III trial comparing whole pelvic versus prostate only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression: Radiation Therapy Oncology Group 9413. J Clin Oncol 21 (2003) 1904-1911
15. Peh W.C., Khong P.L., Yin Y., et al. Imaging of pelvic insufficiency fractures. Radiographics 16 (1996) 335-348
16. Moreno A., Clemente J., Crespo C., et al. Pelvic insufficiency fractures in patients with pelvic irradiation. Int J Radiat Oncol Biol Phys 44 (1999) 61-66
17. Kwon J.W., Huh S.J., Yoon Y.C., et al. Pelvic bone complications after radiation therapy of uterine cervical cancer: Evaluation with MRI. AJR An J Roentgenol 191 (2008) 987-994
18. Heron J., Connell D.A., and James S.L. CT-guided sacroplasty for the treatment of sacral insufficiency fractures. Clin Radiol 62 (2007) 1094-1100
19. Herman M.P., Kopetz S., Bhosale P.R., et al. Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: Incidence, risk factors, and clinical course. Int J Radiat Oncol Biol Phys 74 (2009) 818-823
20. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology. Prostae cancer v.1, 2009. Available at: http://www.nccn.org/professionals/physician_gls/PDF/prostate.pdf. Accessed on January 26, 2009.
21. Bolla M., Gonzalez D., Warde P., et al. Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl J Med 337 (1997) 295-300
22. Messing E.M., Manola J., Sarosdy M., et al. Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node positive prostate cancer. N Engl J Med 341 (1999) 1781-1788
23. Morote J., Orsola A., Abascal J.M., et al. Bone mineral density changes in patients with prostate cancer during the first 2 years of androgen suppression. J Urol 175 (2006) 1679-1683
24. Greenspan S.L., Coates P., Sereika S.M., et al. Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer. J Clin Endocrinol Metab 90 (2005) 6410-6417
25. Abrahamsen B., Nielsen M.F., Eskildsen P., et al. Fracture risk in Danish men with prostate cancer: A nationwide register study. BJU Int 100 (2007) 749-754
26. Shahinian V.B., Kou Y.F., Freeman J.L., et al. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med 352 (2005) 154-164
27. Cummings S.R., and Melton L.J. Epidemiology and outcomes of osteoporotic fractures. Lancet 359 (2002) 1761-1767
28. Schechter N.R., and Lewis V.O. The bone. In: Cox J.D., and Ang K.K. (Eds). Radiation oncology. Rationale, technique, results (2003), Mosby, St. Louis, MO 857-883
29. Saad F., Adachi J.D., Brown J.P., et al. Cancer treatment-induced bone loss in breast and prostate cancer. J Clin Oncol 26 (2008) 5465-5476
30. Greenspan S.L. Approach to the prostate cancer patient with bone disease. J Clin Endocrinol Metab 93 (2008) 2-7
31. Fu A.L., Greven K.M., and Maruyama Y. Radiation osteitis and insufficiency fractures after pelvic irradiation for gynecologic malignancies. Am J Clin Oncol 17 (1994) 248-254