Blockade of androgen or estrogen receptors reduces nandrolone's ability to modulate acute reward-related neurochemical effects of amphetamine in rat brain

Pharmacology Biochemistry and Behavior

Volumn 95, Issue 4, 2010, Pages 422-427

  Kurling Kailanto, Sanna ^a   Kankaanpää, Aino ^a   Hautaniemi, Janne ^a   Seppälä, Timo ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

5 HT; Amphetamine; Anabolic androgenic steroids; Androgen receptor; Dopamine; Estrogen receptor; Nucleus accumbens

Indexed keywords

AMPHETAMINE; ANDROGEN RECEPTOR; CLOMIFENE; DOPAMINE; ESTROGEN RECEPTOR; FLUTAMIDE; NANDROLONE DECANOATE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DRUG DEPENDENCE; DRUG MECHANISM; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REWARD; SEROTONINERGIC SYSTEM;

ADRENERGIC AGENTS; AMPHETAMINE; ANABOLIC AGENTS; ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; BRAIN; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG INTERACTIONS; ESTROGEN ANTAGONISTS; MALE; NANDROLONE; NEURONS; NUCLEUS ACCUMBENS; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; REWARD; TIME FACTORS;

RATTUS;

EID: 77952550834     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.02.020     Document Type: Article

References (46)

1. Alderson L.M., Baum M.J. Differential effects of gonadal steroids on dopamine metabolism in mesolimbic and nigro-striatal pathways of male rat brain. Brain Res 1981, 218:189-206.
2. Arvary D., Pope H.G. Anabolic-androgenic steroids as a gateway to opioid dependence. N Engl J Med 2000, 342:1532.
3. Balthazart J., Foidart A., Houbart M., Prins G.S., Ball G.F. Distribution of androgen receptor-immunoreactive cells in the quail forebrain and their relationship with aromatase immunoreactivity. J Neurobiol 1998, 35:323-340.
4. Becker J.B. Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacol Biochem Behav 1999, 64:803-812.
5. Bitar M.S., Ota M., Linnoila M., Shapiro B.H. Modification of gonadectomy-induced increases in brain monoamine metabolism by steroid hormones in male and female rats. Psychoneuroendocrinology 1991, 16:547-557.
6. Bowman S.P., Leake A., Morris I.D. Time-related effects of en-clomiphene upon central and peripheral oestrogen target tissues and cytoplasmic receptors. J Endocrinol 1981, 89:117-128.
7. Di Paolo T., Rouillard C., Bedard P. 17 Beta-estradiol at a physiological dose acutely increases dopamine turnover in rat brain. Eur J Pharmacol 1985, 117:197-203.
8. DuRant R.H., Escobedo L.G., Heath G.W. Anabolic-steroid use, strength training, and multiple drug use among adolescents in the United States. Pediatrics 1995, 96:23-28.
9. Frye C.A. Some rewarding effects of androgens may be mediated by actions of its 5alpha-reduced metabolite 3alpha-androstanediol. Pharmacol Biochem Behav 2007, 86:354-367.
10. Hart J.E. Pituitary-related weight changes affecting the liver, uterus and adrenal glands of rats treated with hexoestrol and clomiphene in high doses. Toxicology 1990, 61:185-194.
11. Hernandez L., Gonzalez L., Murzi E., Paez X., Gottberg E., Baptista T. Testosterone modulates mesolimbic dopaminergic activity in male rats. Neurosci Lett 1994, 171:172-174.
12. Hotchkiss A.K., Ostby J.S., Vandenburgh J.G., Gray L.E. Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat. Environ Health Perspect 2002, 110(Suppl 3):435-439.
13. Janne O.A. Androgen interaction through multiple steroid receptors. NIDA Res Monogr 1990, 102:178-186.
14. Kanayama G., Cohane G.H., Weiss R.D., Pope H.G. Past anabolic-androgenic steroid use among men admitted for substance abuse treatment: an underrecognized problem?. J Clin Psychiatry 2003, 64:156-160.
15. Kankaanpää A., Meririnne E., Ariniemi K., Seppala T. Oxalic acid stabilizes dopamine, serotonin, and their metabolites in automated liquid chromatography with electrochemical detection. J Chromatogr B Biomed Sci Appl 2001, 753:413-419.
16. Kelce W.R., Lambright C.R., Gray L.E., Roberts K.P. Vinclozolin and p, p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism. Toxicol Appl Pharmacol 1997, 142:192-200.
17. Kindlundh A.M., Isacson D.G., Berglund L., Nyberg F. Doping among high school students in Uppsala, Sweden: a presentation of the attitudes, distribution, side effects, and extent of use. Scand J Soc Med 1998, 26:71-74.
18. Kindlundh A.M., Isacson D.G., Berglund L., Nyberg F. Factors associated with adolescent use of doping agents: anabolic-androgenic steroids. Addiction 1999, 94:543-553.
19. Kindlundh A.M., Lindblom J., Bergstrom L., Nyberg F. The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Neuroscience 2003, 119:113-120.
20. Kritzer M.F. Selective colocalization of immunoreactivity for intracellular gonadal hormone receptors and tyrosine hydroxylase in the ventral tegmental area, substantia nigra, and retrorubral fields in the rat. J Comp Neurol 1997, 379:247-260.
21. Kurling S., Kankaanpää A., Ellermaa S., Karila T., Seppälä T. The effect of sub-chronic nandrolone decanoate treatment on dopaminergic and serotonergic neuronal systems in the brains of rats. Brain Res 2005, 1044:67-75.
22. Kurling S., Kankaanpää A., Seppälä T. Sub-chronic nandrolone treatment modifies neurochemical and behavioral effects of amphetamine and 3, 4-methylenedioxymethamphetamine (MDMA) in rats. Behav Brain Res 2008, 189:191-201.
23. Lammers C.H., D'Souza U., Qin Z.H., Lee S.H., Yajima S., Mouradian M.M. Regulation of striatal dopamine receptors by estrogen. Synapse 1999, 34:222-227.
24. Landry M., Levesque D., Di Paolo T. Estrogenic properties of raloxifene, but not tamoxifen, on D2 and D3 dopamine receptors in the rat forebrain. Neuroendocrinology 2002, 76:214-222.
25. Lukas S.E. CNS effects and abuse liability of anabolic-androgenic steroids. Annu Rev Pharmacol Toxicol 1996, 36:333-357.
26. Masonis A.E., McCarthy M.P. Direct effects of the anabolic/androgenic steroids, stanozolol and 17 alpha-methyltestosterone, on benzodiazepine binding to the gamma-aminobutyric acid(a) receptor. Neurosci Lett 1995, 189:35-38.
27. McCall W.V., Ellinwood E.H., Nishita J.K., Lee T.H. Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons. Res Commun Chem Pathol Pharmacol 1988, 60:141-144.
28. McCormick C.M., Mahoney E. Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats. Horm Behav 1999, 35:90-101.
29. Meilman P.W., Crace R.K., Presley C.A., Lyerla R. Beyond performance enhancement: polypharmacy among collegiate users of steroids. J Am Coll Health 1995, 44:98-104.
30. Menard C.S., Harlan R.E. Up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids. Brain Res 1993, 622:226-236.
31. Mermelstein P.G., Becker J.B., Surmeier D.J. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci 1996, 16:595-604.
32. Mitchell J.B., Stewart J. Effects of castration, steroid replacement, and sexual experience on mesolimbic dopamine and sexual behaviors in the male rat. Brain Res 1989, 491:116-127.
33. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1986, Academic Press Inc, San Diego.
34. Roselli C.E. The effect of anabolic-androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area. Brain Res 1998, 792:271-276.
35. Ryan K.J. Biological aromatization of steroids. J Biol Chem 1959, 234:268-272.
36. Sato S.M., Schulz K.M., Sisk C.L., Wood R.I. Adolescents and androgens, receptors and rewards. Horm Behav 2008, 53:647-658.
37. Schade K., Schubert K. Estrogen biosynthesis and its inhibition - a review. Endokrinologie 1979, 74:90-99.
38. Scott D.M., Wagner J.C., Barlow T.W. Anabolic steroid use among adolescents in Nebraska schools. Am J Health Syst Pharm 1996, 53:2068-2072.
39. Skarberg K., Nyberg F., Engstrom I. The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports. Subst Abuse Treat Prev Policy 2008, 3:24.
40. Stumpf W.E., Sar M. Steroid hormone target sites in the brain: the differential distribution of estrogin, progestin, androgen and glucocorticosteroid. J Steroid Biochem 1976, 7:1163-1170.
41. Thiblin I., Finn A., Ross S.B., Stenfors C. Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids. Br J Pharmacol 1999, 126:1301-1306.
42. Thompson T.L., Moss R.L. Estrogen regulation of dopamine release in the nucleus accumbens: genomic- and nongenomic-mediated effects. J Neurochem 1994, 62:1750-1756.
43. van de Poll N.E., van Zanten S., de Jonge F.H. Effects of testosterone, estrogen, and dihydrotestosterone upon aggressive and sexual behavior of female rats. Horm Behav 1986, 20:418-431.
44. Vermes I., Varszegi M., Toth E.K., Telegdy G. Action of androgenic steroids on brain neurotransmitters in rats. Neuroendocrinology 1979, 28:386-393.
45. Wesson D.W., McGinnis M.Y. Stacking anabolic androgenic steroids (AAS) during puberty in rats: a neuroendocrine and behavioral assessment. Pharmacol Biochem Behav 2006, 83:410-419.
46. Yesalis C.E., Bahrke M.S. Anabolic-androgenic steroids. Curr Issues Sports Med 1995, 19:326-340.