Synthesis and antitumor activity of 3,4,5-substituted 1,2,4-triazoles

Pharmaceutical Chemistry Journal

Volumn 43, Issue 12, 2009, Pages 645-648

  Ovsepyan, T R ^a   Melik Ogandzhanyan, R G ^a   Panosyan, G A ^a   Arsenyan, F G ^a   Garibdzhanyan, B T ^a  

^a Molecular Structure Research Center Yerevan   (Armenia)

Author keywords

1,2,4 triazole; Antitumor activity; Synthesis

Indexed keywords

1 [4 BROMOPHENYL (4 BROMOPHENOXYMETHYLENE)] 4 PHENYL(BENZYL, ALLYL) 3 THIOSEMICARBAZIDE DERIVATIVE; 3 [4 BROMOPHENYL(4 BROMOPHENOXYMETHYLENE)] 4 PHENYL(BENZYL, ALLYL) 5 MERCAPTO 1,2,4 TRIAZOLE DERIVATIVE; 3 [4 BROMOPHENYL(4 BROMOPHENOXYMETHYLENE)] 4 PHENYL(BENZYL, ALLYL) 5 MERCAPTO SUBSTITUTED 1,2,4 TRIAZOLE DERIVATIVE; 3,4,5 SUBSTITUTED 1,2,4 TRIAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; NEW DRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SARCOMA; THIN LAYER CHROMATOGRAPHY; TUMOR XENOGRAFT;

EID: 77952548287     PISSN: 0091150X     EISSN: 15739031     Source Type: Journal    
DOI: 10.1007/s11094-010-0371-3     Document Type: Article

References (7)

1. A Kh Avetisyan TR Ovsepyan NO Stepanyan LG Sapondzhyan 1981 Khim.-farm. Zh. 15 6 60 72
2. TR Ovsepyan AKh Avetisyan SM Terdzhanyan, et al. 1990 Arm. Khim. Zh. 43 399 403 1:CAS:528:DyaK3MXht1aiu74%3D
3. V Baretrias JH Marriott C Melin, et al. 2000 J. Med. Chem. 43 1910 1926 10.1021/jm991119p (Pubitemid 30340931)
4. Fr. Pat. No. 2,221,138; Izobret. za Rubezhom, No. 15, No. 24 (1974).
5. TR Ovsepyan ER Dilanyan AP Engoyan RG Melik-Ogandzhanyan 2004 Khim. Geterotsikl. Soedin. 9 1377 1379
6. G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Medgiz, Moscow (1971).
7. Z. P. Sof(ina, A. B. Syrkin, et al., Experimental Evaluation of Antitumor Compounds in the USSR and USA [in Russian], Meditsina, Moscow (1980).