Lipopolysaccharide and TNF-α modify adenosine A2A receptor expression and function in equine monocytes

Veterinary Immunology and Immunopathology

Volumn 135, Issue 3-4, 2010, Pages 289-295

  Sun, Wan chun ^a   Berghaus, Londa J ^a   Moore, James N ^a   Hurley, David J ^a   Vandenplas, Michel L ^a   Thompson, Robert ^c   Linden, Joel ^b  

^a UNIVERSITY OF GEORGIA   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c A Division of Clinical Data Inc   (United States)

Author keywords

Adenosine receptor; ATL313; Inflammation; Lipopolysaccharide; Monocyte; MRNA expression; Tumor necrosis factor

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL INFECTION; CELL ISOLATION; CELL LINE; CELL TYPE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENDOTOXEMIA; GENETIC TRANSCRIPTION; HORSE; INCUBATION TIME; INHIBITION KINETICS; MACROPHAGE; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; DNA PRIMERS; HORSE DISEASES; HORSES; HUMANS; LIPOPOLYSACCHARIDES; MICE; MONOCYTES; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2A; RECOMBINANT PROTEINS; RNA, MESSENGER; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRIAZINES; TRIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS); EQUIDAE; MURINAE;

EID: 77952544122     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2009.12.001     Document Type: Article

References (33)

1. Alam M.S., Kurtz C.C., Wilson J.M., Burnette B.R., Wiznerowicz E.B., Ross W.G., Rieger J.M., Figler R.A., Linden J., Crowe S.E., Ernst P.B. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunol. 2009, 2:232-242.
2. Brandon C.I., Vandenplas M., Dookwah H., Linden J., Murray T.F. Cloning and pharmacological characterization of the equine adenosine A2A receptor: a potential therapeutic target for the treatment of equine endotoxemia. J. Vet. Pharmacol. Ther. 2006, 29:243-253.
3. Brandon C.I., Vandenplas M., Dookwah H., Murray T.F. Cloning and pharmacological characterization of the equine adenosine A3 receptor. J. Vet. Pharmacol. Ther. 2006, 29:255-263.
4. Bshesh K., Zhao B., Spight D., Biaggioni I., Feokistov I., Denenberg A., Wong H.R., Shanley T.P. The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. J. Leukoc. Biol. 2002, 72:1027-1036.
5. Capecchi P.L., Camurri A., Pompella G., Mazzola A., Maccherini M., Diciolla F., Lazzerini P.E., Abbracchio M.P., Laghi-Pasini F. Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation. J. Card. Fail. 2005, 11:67-73.
6. Csoka B., Nemeth Z.H., Virag L., Gergely P., Leibovich S.J., Pacher P., Sun C.X., Blackburn M.R., Vizi E.S., Deitch E.A., Hasko G. A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood 2007, 110:2685-2695.
7. Ezeamuzie C.I., Khan I. The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int. Immunopharmacol. 2007, 7:483-490.
8. Figueiredo M.D., Moore J.N., Vandenplas M.L., Sun W.C., Murray T.F. Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin in [corrected] equine whole blood and monocytes. Am. J. Vet. Res. 2008, 69:796-803.
9. Figueiredo M.D., Salter C.E., Andrietti A.L., Vandenplas M.L., Hurley D.J., Moore J.N. Validation of a reliable set of primer pairs for measuring gene expression by real-time quantitative RT-PCR in equine leukocytes. Vet. Immunol. Immunopathol. 2009, 131:65-72.
10. Fortin A., Harbour D., Fernandes M., Borgeat P., Bourgoin S. Differential expression of adenosine receptors in human neutrophils: up-regulation by specific Th1 cytokines and lipopolysaccharide. J. Leukoc. Biol. 2006, 79:574-585.
11. Fredholm B.B., Ijzerman A.P., Jacobson K.A., Klotz K.N., Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 2001, 53:527-552.
12. Hasko G., Kuhel D.G., Chen J.F., Schwarzschild M.A., Deitch E.A., Mabley J.G., Marton A., Szabo C. Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J. 2000, 14:2065-2074.
13. Hasko G., Linden J., Cronstein B., Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 2008, 7:759-770.
14. Hasko G., Pacher P., Deitch E.A., Vizi E.S. Shaping of monocyte and macrophage function by adenosine receptors. Pharmacol. Ther. 2007, 113:264-275.
15. Hasko G., Szabo C., Nemeth Z.H., Kvetan V., Pastores S.M., Vizi E.S. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264. 7 macrophages and in endotoxemic mice. J. Immunol. 1996, 157:4634-4640.
16. Khoa N.D., Montesinos M.C., Reiss A.B., Delano D., Awadallah N., Cronstein B.N. Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. J. Immunol. 2001, 167:4026-4032.
17. Khoa N.D., Postow M., Danielsson J., Cronstein B.N. Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane. Mol. Pharmacol. 2006, 69:1311-1319.
18. Kreckler L.M., Wan T.C., Ge Z.D., Auchampach J.A. Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. Pharmacol. Exp. Ther. 2006, 317:172-180.
19. Lappas C.M., Sullivan G.W., Linden J. Adenosine A2A agonists in development for the treatment of inflammation. Expert Opin Investig Drugs. 2005, 14:797-806.
20. Lu Y.C., Yeh W.C., Ohashi P.S. LPS/TLR4 signal transduction pathway. Cytokine 2008, 42:145-151.
21. Morello S., Ito K., Yamamura S., Lee K.Y., Jazrawi E., Desouza P., Barnes P., Cicala C., Adcock I.M. IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter. J. Immunol. 2006, 177:7173-7183.
22. Murphree L.J., Sullivan G.W., Marshall M.A., Linden J. Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. Biochem. J. 2005, 391:575-580.
23. Nguyen D.K., Montesinos M.C., Williams A.J., Kelly M., Cronstein B.N. Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. J. Immunol. 2003, 171:3991-3998.
24. Sipka S., Kovacs I., Szanto S., Szegedi G., Brugos L., Bruckner G., Jozsef Szentmiklosi A. Adenosine inhibits the release of interleukin-1beta in activated human peripheral mononuclear cells. Cytokine 2005, 31:258-263.
25. Streitova D., Hofer M., Hola J., Vacek A., Pospisil M. Adenosine A1, A2a, A2b, and A3 receptors in hematopoiesis. 2. Expression of receptor mRNA in resting and lipopolysaccharide-activated mouse RAW 264.7 macrophages. Physiol. Res. 2009.
26. Sullivan G.W., Lee D.D., Ross W.G., DiVietro J.A., Lappas C.M., Lawrence M.B., Linden J. Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils. J. Leukoc. Biol. 2004, 75:127-134.
27. Sun W.C., Cao Y., Jin L., Wang L.Z., Meng F., Zhu X.Z. Modulating effect of adenosine deaminase on function of adenosine A1 receptors. Acta Pharmacol. Sin. 2005, 26:160-165.
28. Sun W.C., Moore J.N., Hurley D.J., Vandenplas M.L., Linden J., Cao Z., Murray T.F. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes. Vet. Immunol. Immunopathol. 2008, 121:91-100.
29. Sun W.C., Moore J.N., Hurley D.J., Vandenplas M.L., Linden J.M., Murray T.F. Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils. Am. J. Vet. Res. 2007, 68:981-987.
30. Sun W.C., Moore J.N., Hurley D.J., Vandenplas M.L., Murray T.F. Effects of stimulation of adenosine A2A receptors on lipopolysaccharide-induced production of reactive oxygen species by equine neutrophils. Am. J. Vet. Res. 2007, 68:649-656.
31. Takahashi H.K., Kanke T., Liu K., Yoshino T., Sendo T., Tanaka N., Nishibori M. Adenosine A2A-receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 production in monocytes. J. Pharmacol. Sci. 2007, 104:183-186.
32. Trevethick M.A., Mantell S.J., Stuart E.F., Barnard A., Wright K.N., Yeadon M. Treating lung inflammation with agonists of the adenosine A2A receptor: Promises, problems and potential solutions. Br. J. Pharmacol. 2008, 155:463-474.
33. van der Putten C., Zuiderwijk-Sick E.A., van Straalen L., de Geus E.D., Boven L.A., Kondova I., Ijzerman A.P., Bajramovic J.J. Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia. J. Immunol. 2009, 182:7603-7612.