The regulation of MDM2 by multisite phosphorylation-Opportunities for molecular-based intervention to target tumours?

Seminars in Cancer Biology

Volumn 20, Issue 1, 2010, Pages 19-28

  Meek, David W ^a   Hupp, Ted R ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Anti tumour; MDM2; MDMX; P53; Peptide docking; Phosphorylation; Therapeutics

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; PEPTIDE DERIVATIVE; PEPTIDOMIMETIC AGENT; PROTEASOME; PROTEIN MDM2; PROTEIN MDM2 INHIBITOR; PROTEIN MDMX; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; CARCINOGENESIS; CELL AGING; CELL STRESS; CELL SURVIVAL; DNA DAMAGE; DRUG TARGETING; GENE EXPRESSION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DOCKING; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 77952542570     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2009.10.005     Document Type: Review

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