Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: An in vitro study

BMC Musculoskeletal Disorders

Volumn 11, Issue , 2010, Pages

  Mathijssen, Nina M C ^a   Petit, Pieter L C ^b   Pilot, Peter ^c   Schreurs, B Wim ^d   Buma, Pieter ^d   Bloem, Rolf M ^a,c  

^a Netherlands Bone Bank Foundation   (Netherlands)

^b Vlietland Hospital   (Netherlands)

^c Reinier de Graaf Gasthuis ^*  (Netherlands)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CEFAZOLIN; CLINDAMYCIN; LINEZOLID; OXACILLIN; VANCOMYCIN; ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; OXAZOLIDINONE DERIVATIVE;

ALLOGRAFT; ANTIMICROBIAL ACTIVITY; ARTICLE; BONE CHIP; BONE GRAFT; CONTROLLED STUDY; DOSE RESPONSE; DRUG SOLUTION; DRUG STORAGE; INFECTION PREVENTION; JOINT PROSTHESIS; JOINT SURGERY; NONHUMAN; PILL; STAPHYLOCOCCUS EPIDERMIDIS; STORAGE TEMPERATURE; ALLOTRANSPLANTATION; ANTIBIOTIC PROPHYLAXIS; BONE TRANSPLANTATION; CHEMISTRY; DRUG EFFECT; DRUG FORMULATION; DRUG STABILITY; HUMAN; INFECTION; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; PHYSIOLOGY; SURGICAL INFECTION; TEMPERATURE;

ACETAMIDES; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; BONE TRANSPLANTATION; CEFAZOLIN; CLINDAMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; HUMANS; MICROBIAL SENSITIVITY TESTS; OXACILLIN; OXAZOLIDINONES; PROSTHESIS-RELATED INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; SURGICAL WOUND INFECTION; TEMPERATURE; TRANSPLANTATION, HOMOLOGOUS; VANCOMYCIN;

EID: 77952536061     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-11-96     Document Type: Article

References (30)

1. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. JD Whitehouse ND Friedman KB Kirkland WJ Richardson DJ Sexton, Infect Control Hosp Epidemiol 2002 23 4 183 189 10.1086/502033 12002232
2. The socioeconomic burden of hospital acquired infection. R Plowman, Euro Surveill 2000 5 4 49 50 12631865
3. Bone grafting in total hip replacement for acetabular protrusion. TJ Slooff R Huiskes J van Horn AJ Lemmens, Acta Orthop Scand 1984 55 6 593 596 10.3109/17453678408992402 6395620
4. Impacted cancellous allografts and cement for revision total hip arthroplasty. GA Gie L Linder RS Ling JP Simon TJ Slooff AJ Timperley, The Journal of bone and joint surgery 1993 75 1 14 21 (Pubitemid 23052407)
5. Acetabular revision with impacted morsellised cancellous bone grafting and a cemented cup. A 15- to 20-year follow-up. BW Schreurs SB Bolder JW Gardeniers N Verdonschot TJ Slooff RP Veth, The Journal of bone and joint surgery 2004 86 4 492 497
6. Acetabular revision with impacted morselized cancellous bone graft and a cemented cup in patients with rheumatoid arthritis: three to fourteen-year follow-up. BW Schreurs TM Thien MC de Waal Malefijt P Buma RP Veth TJ Slooff, J Bone Joint Surg Am 2003 85-A 4 647 652 12672840
7. Acetabular revision with impacted morselized cancellous bone graft and a cemented cup in patients with rheumatoid arthritis. A concise follow-up, at eight to nineteen years, of a previous report. BW Schreurs J Luttjeboer TM Thien MC de Waal Malefijt P Buma RP Veth TJ Slooff, J Bone Joint Surg Am 2009 91 3 646 651 10.2106/JBJS.G.01701 19255226
8. Acetabular reconstruction with bone impaction grafting and a cemented cup: 20 years' experience. BW Schreurs TJ Slooff JW Gardeniers P Buma, Clinical orthopaedics and related research 2001 393 202 215
9. Femoral component revision with use of impaction bone-grafting and a cemented polished stem. BW Schreurs JJ Arts N Verdonschot P Buma TJ Slooff JW Gardeniers, J Bone Joint Surg Am 2005 87 11 2499 2507 10.2106/JBJS.D.02547 16264127
10. Femoral component revision with use of impaction bone-grafting and a cemented polished stem. Surgical technique. BW Schreurs JJ Arts N Verdonschot P Buma TJ Slooff JW Gardeniers, J Bone Joint Surg Am 2006 2 88 Suppl 1 Pt 259 274 10.2106/JBJS.F.00340
11. Acetabular reconstruction with impacted morsellised cancellous bone graft and cement. A 10- to 15-year follow-up of 60 revision arthroplasties. BW Schreurs TJ Slooff P Buma JW Gardeniers R Huiskes, The Journal of bone and joint surgery 1998 80 3 391 395 10.1302/0301-620X.80B3.8534 (Pubitemid 28230564)
12. Efficacy of antibiotic-impregnated cement in total hip replacement. J Parvizi KJ Saleh PS Ragland AE Pour MA Mont, Acta Orthop 2008 79 3 335 341 10.1080/17453670710015229 18622836
13. Revision total hip arthroplasty in octogenarians. A case-control study. J Parvizi AE Pour NR Keshavarzi M D'Apuzzo PF Sharkey WJ Hozack, J Bone Joint Surg Am 2007 89 12 2612 2618 10.2106/JBJS.F.00881 18056492
14. Infection after total hip arthroplasty. The Avon experience. AW Blom AH Taylor G Pattison S Whitehouse GC Bannister, The Journal of bone and joint surgery 2003 85 7 956 959 10.1302/0301-620X.85B7.14095 12728049
15. Gentamicin may have an adverse effect on osteogenesis. S Isefuku CJ Joyner AH Simpson, Journal of orthopaedic trauma 2003 17 3 212 216 10.1097/00005131-200303000-00010 12621263
16. Bacterial adherence to biomaterials and tissue. The significance of its role in clinical sepsis. AG Gristina JW Costerton, J Bone Joint Surg Am 1985 67 2 264 273 3881449
17. Infection of orthopedic implants and the use of antibiotic-loaded bone cements. A review. H van de Belt D Neut W Schenk JR van Horn HC van der Mei HJ Busscher, Acta Orthop Scand 2001 72 6 557 571 10.1080/000164701317268978 11817870
18. Bone grafts impregnated with antibiotics as a tool for treating infected implants in orthopedic surgery - one stage revision results. H Winkler K Kaudela A Stoiber F Menschik, Cell and tissue banking 2006 7 4 319 323 10.1007/s10561-006-9010-3 16710632
19. Release of netilmicin and vancomycin from cancellous bone. E Witso L Persen P Benum K Bergh, Acta Orthop Scand 2002 73 2 199 205 10.1080/ 000164702753671812 12079020
20. High local concentrations without systemic adverse effects after impaction of netilmicin-impregnated bone. E Witso L Persen P Benum A Aamodt OS Husby K Bergh, Acta Orthop Scand 2004 75 3 339 346 10.1080/00016470410001295 15260428
21. In vitro release of vancomycin and tobramycin from impregnated human and bovine bone grafts. H Winkler O Janata C Berger W Wein A Georgopoulos, The Journal of antimicrobial chemotherapy 2000 46 3 423 428 10.1093/jac/46.3.423 10980169
22. Cancellous bone as an antibiotic carrier. E Witso L Persen K Loseth P Benum K Bergh, Acta Orthop Scand 2000 71 1 80 84 10.1080/00016470052943955 10743999
23. Cortical allograft as a vehicle for antibiotic delivery. E Witso L Persen P Benum K Bergh, Acta Orthop 2005 76 4 481 486 10.1080/17453670510041457 16195062
24. High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties. MA Buttaro MI Gimenez G Greco L Barcan F Piccaluga, Acta Orthop 2005 76 3 336 340 16156460
25. Incorporation of vancomycin-supplemented bone incorporation of vancomycin-supplemented bone allografts: radiographical, histopathological and immunohistochemical study in pigs. MA Buttaro AM Gonzalez Della Valle L Pineiro E Mocetti AA Morandi F Piccaluga, Acta Orthop Scand 2003 74 5 505 513 10.1080/00016470310017884 14620969
26. Presence and expression of collagen adhesin gene (cna) and slime production in Staphylococcus aureus strains from orthopaedic prosthesis infections. L Montanaro CR Arciola L Baldassarri E Borsetti, Biomaterials 1999 20 20 1945 1949 10.1016/S0142-9612(99)00099-X 10514072
27. Effect of cefazolin and vancomycin on osteoblasts in vitro. ML Edin T Miclau GE Lester RW Lindsey LE Dahners, Clinical orthopaedics and related research 1996 333 245 251
28. Management of Septic Joint Arthroplasty - The Hellenic Experience. NK Malizos NT Roidis TS Karachalios LA Poultsides KA Bargiotas, Local Antibiotics in Arthroplasty State of the art from an interdisciplinary point of view New York: Georg Thieme Verlag, Walenkamp GHIM, 2007 109 119
29. Antibiotic-impregnated cement and beads for orthopedic infections. DA Wininger RJ Fass, Antimicrobial agents and chemotherapy 1996 40 12 2675 2679 9124821
30. Medical Microbiology. PR Murray KS Rosenthal GS Kobayashi MA Pfaller, St. Louis: Mosby 3 1998