Oligoclonal bands and immunoglobulin isotype switch during monitoring of patients with multiple myeloma and autologous hematopoietic cell transplantation: A 16-year experience

Clinical Chemistry and Laboratory Medicine

Volumn 48, Issue 5, 2010, Pages 727-731

  Alejandre, Mariel Emilce ^a   Madalena, Leticia Bibiana ^a   Pavlovsky, Miguel Arturo ^b   Facio, Maria Laura ^a   Corrado, Claudia ^b   Milone, Gustavo ^b   Bresciani, Pablo Diego ^a   Fraind, Susana Alicia ^a   Pavlovsky, Santiago ^b   Pizzolato, Marco Antonio ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Fundacion para Combatir La Leucemia   (Argentina)

Author keywords

Isotype switch; Multiple myeloma; Oligoclonal bands; Prognostic marker; Stem cell transplantation

Indexed keywords

BETA 2 MICROGLOBULIN; CELLULOSE ACETATE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OLIGOCLONAL BAND; PLASMA PROTEIN; SERUM ALBUMIN;

ADULT; AGAR GEL ELECTROPHORESIS; AGED; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER SURVIVAL; DENSITOMETRY; FEMALE; FOLLOW UP; GENE SWITCHING; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; PATIENT MONITORING; PRIORITY JOURNAL; PROTEIN ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; SILVER STAINING; TREATMENT RESPONSE;

ADULT; AGED; BIOLOGICAL MARKERS; DENSITOMETRY; ELECTROPHORESIS, AGAR GEL; FEMALE; FOLLOW-UP STUDIES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOGLOBULIN ISOTYPES; ISOELECTRIC FOCUSING; MALE; MIDDLE AGED; MULTIPLE MYELOMA; OLIGOCLONAL BANDS; PROGNOSIS; TRANSPLANTATION, AUTOLOGOUS;

EID: 77952497843     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.050     Document Type: Article

References (15)

1. Kyle RA, Gertz MA, Witzig TE, Lust J, Lacy M, Dispenzieri A, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003;78:21-33.
2. 45th ASH annual meeting. Multiple myeloma and plasma cell dyscrasias. San Diego, CA: MMRF Multiple Myeloma Research Foundation, 2003.
3. Greipp P, San Miguel J, Durie B, Crowley J, Barlogie B, Bladé J, et al. International staging system for multiple myeloma. J Clin Oncol 2005;23:3412-20.
4. Munshi NC. Investigative tools for diagnosis and management. Hematology Am Soc Hematol Educ Program 2008:298-305.
5. Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, et al. on behalf of the International Myeloma Working Group. Guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 2009;23:215-24.
6. Zent CS, Wilson CS, Tricot G, Jagannath S, Siegel D, Desikan KR, et al. Oligoclonal proteins bands and immunoglobulin iso-type switching in multiple myeloma. Treated with high-dose therapy and hematopoietic cell transplantation. Blood 1998;91:3518-23.
7. Hovenga S, de Wolf JT, Guikema JE, Klip H, Smit JW, Smit Sibinga CT, et al. Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation. Bone Marrow Transpl 2000;25:723-8.
8. Avet-Loiseau H, Attal M, Moreau P, Charbonnel C, Garban F, Hulin C, et al. Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome. Blood 2007;109:3489-95.
9. Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 2009;23:3-9.
10. Bossuyt X, Bogaerts A, Schiettekatte G, Blanckaert N. Serum protein electrophoresis and immunofixation by a semiautomated electrophoresis system. Clin Chem 1998;44:944-9. (Pubitemid 28213133)
11. García M, Madalena L, Bragantini G, Bresciani P, Pizzolato M. Electroinmunofijación de orinas sin concentrar por coloración con metales pesados. Acta Bioquímica Clínica Latinoamericana 1996;3:215-20. (Pubitemid 126580104)
12. Alejandre M, Madalena L, Facio M, Bresciani P, Fraind S, Cor-rado C, et al. Bandas proteicas anómalas post-trasplante autó-logo de médula ósea en pacientes con mieloma múltiple. Bioquímica y Patología Clínica 2000;64:25-31.
13. Hari PN, Zhang MJ, Roy V, Pérez WS, Bashey A, To LB, et al. Is the international staging system superior to the Durie-Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant leukemia advance online publication 26 March 2009; doi: 10.1038/leu.2009.61.
14. Fernández de Larrea MT, Cibeira M, Rosiñol L, Rovira M, Arostegui J, Fililla X, et al. Abnormal serum free-light chain ratio in patients with multiple myeloma in long-lasting complete remission: strong association with oligoclonal bands. Hae-matologica 2009;94(Suppl 2):149 abs.0375.
15. Katzman J, Kyle RA, Benson J, Larson DR, Snyder MR, Lust JA, et al. Screening panels for detection of monoclonal gam-mopathies. Clin Chem 2009;55:1517-22.