Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation

Neurology

Volumn 74, Issue 20, 2010, Pages 1607-1610

  Gliebus, G ^a,b   Bigio, E H ^a,b   Gasho, K ^a   Mishra, M ^a   Caplan, D ^c   Mesulam, M M ^a,b   Geula, C ^d  

^a Northwestern Mesulam Center for Cognitive Neurology and Alzheimer's Disease   (United States)

^b Neurology   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; PROGRANULIN; TAR DNA BINDING PROTEIN;

AGED; ANALYSIS OF VARIANCE; ARTICLE; BRAIN ATROPHY; BRAIN CORTEX; BRAIN REGION; CASE REPORT; CELL INCLUSION; CELL NUCLEUS INCLUSION BODY; DENTATE GYRUS; ENTORHINAL CORTEX; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LANGUAGE; MEMORY; NERVE CELL NECROSIS; NEURITE; NEUROFIBRILLARY TANGLE; OLFACTORY NUCLEUS; ORBITAL CORTEX; PHENOTYPE; PRIMARY PROGRESSIVE APHASIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; STEREOMETRY; SUBICULUM;

AGED; ANALYSIS OF VARIANCE; APHASIA, PRIMARY PROGRESSIVE; BRAIN; CELL COUNT; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCLUSION BODIES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; NEUROFIBRILLARY TANGLES; NEURONS; PEDIGREE;

EID: 77952496156     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181df0a1b     Document Type: Article

References (9)

1. Weintraub S, Mesulam M. With or without FUS, it is the anatomy that dictates the dementia phenotype. Brain 2009;132:2906-2908.
2. Mesulam M, Johnson N, Krefft TA, et al. Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families. Arch Neurol 2007;64:43-47.
3. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): part II: standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-486.
4. Mackenzie IR, Baborie A, Pickering-Brown S, et al. Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical pheno-type. Acta Neuropathol 2006;112:539-549.
5. Sampathu DM, Neumann M, Kwong LK, et al. Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. Am J Pathol 2006;169:1343-1352.
6. Guillozet AL, Weintraub S, Mash DC, Mesulam MM. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 2003;60:729-736.
7. Mesulam M, Wicklund A, Johnson N, et al. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol 2008;63:709-719.
8. Rabinovici GD, Jagust WJ, Furst AJ, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol 2008;64:388-401.
9. Kelley BJ, Haidar W, Boeve BF, et al. Prominent pheno-typic variability associated with mutations in Progranulin. Neurobiol Aging 2009;30:739-751.