Glycated hemoglobin (HbA1c): Old dogmas, a new perspective?

Clinical Chemistry and Laboratory Medicine

Volumn 48, Issue 5, 2010, Pages 609-614

  Lippi, Giuseppe ^a   Targher, Giovanni ^b  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Diabetes; Diagnosis; Glycated hemoglobin; HbA1c; Screening

Indexed keywords

ALCOHOL; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CYCLOSPORIN; DIAZOXIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISOPYRAMIDE; FIBRIC ACID DERIVATIVE; GLUCOSE; HEMOGLOBIN A1C; LITHIUM; MINOXIDIL; MONOAMINE OXIDASE INHIBITOR; NICOTINIC ACID; OCTREOTIDE; ORAL CONTRACEPTIVE AGENT; PARACETAMOL; PENTAMIDINE; PHENOTHIAZINE; PHENYTOIN; SALICYLIC ACID; SEX HORMONE; STREPTOZOCIN; SULFAMETHOXAZOLE; THIAZIDE DIURETIC AGENT; THYROID HORMONE; TRICYCLIC ANTIDEPRESSANT AGENT;

ACCURACY; ACUTE STRESS; ALCOHOL CONSUMPTION; ARTICLE; BLOOD GLUCOSE MONITORING; CIRCADIAN RHYTHM; COST; DIABETES MELLITUS; DIAGNOSTIC ERROR; DIAGNOSTIC PROCEDURE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY ANEMIA; KIDNEY FAILURE; LABORATORY TEST; PRIORITY JOURNAL; RISK ASSESSMENT; SCREENING; SENSITIVITY ANALYSIS; TURNOVER TIME;

BLOOD GLUCOSE; DIABETES MELLITUS; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; RISK FACTORS;

EID: 77952472238     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.144     Document Type: Article

References (36)

1. American Diabetes Association. Standards of medical care in diabetes - 2010. Diabetes Care 2010;33: S11-61.
2. Rahbar S, Blumenfeld O, Ranney HM. Studies of an unusual hemoglobin in patients with diabetes mellitus. Biochem Bio-phys Res Commun 1969;36:838-43.
3. Bloomgarden ZT. A1C: recommendations, debates, and questions. Diabetes Care 2009;32: e141-7.
4. DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86.
5. Beckles GL, Engelgau MM, Narayan KM, Herman WH, Aubert RE, Williamson DF. Population-based assessment of the level of care among adults with diabetes in the U. S. Diabetes Care 1998;21:1432-8.
6. Salvagno GL, Lippi G, Targher G, Montagnana M, Guidi GC. Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin? Clin Chem Lab Med 2007;45:1065-7.
7. International Diabetes Federation (IDF). Global guideline for type 2 diabetes 2005. Available at: www.idf.org. Last accessed: Jan 12, 2010.
8. National Committee for Quality Assurance. Available at: http://web.ncqa.org/tabid/139/Default.aspx. Last accessed: Jan 12, 2010.
9. Consensus Committee. Consensus statement on the worldwide standardization of the hemoglobin A1C measurement: the American Diabetes Association, European Association for the Study of Diabetes, International Federation of Clinical Chemistry and Laboratory Medicine, and the International Diabetes Federation. Diabetes Care 2007;30:2399-400.
10. Bennett CM, Guo M, Dharmage SC. HbA (1c) as a screening tool for detection of type 2 diabetes: a systematic review. Diabet Med 2007;24:333-43.
11. Saudek CD, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab 2008;93:2447-53.
12. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2010;33: S62-9.
13. International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009;32:1327-34.
14. Selvin E, Crainiceanu CM, Brancati FL, Coresh J. Short-term variability in measures of glycemia and implications for the classification of diabetes. Arch Intern Med 2007;167:1545-51.
15. Pandit MK, Burke J, Gustafson AB, Minocha A, Peiris AN. Drug-induced disorders of glucose tolerance. Ann Intern Med 1993;118:529-39.
16. Gama R, Likhari T. Diagnosis of diabetes. Haemoglobin A1c: ethnic differences apply to the UK. Br Med J 2009;339:b5648.
17. El-Agouza I, Abu SA, Sirdah M. The effect of iron deficiency anaemia on the levels of haemoglobin subtypes: possible consequences for clinical diagnosis. Clin Lab Haematol 2002;24:285-9.
18. Coban E, Ozdogan M, Timuragaoglu A. Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients. Acta Haematol 2004;112:126-8.
19. Selvin E, Zhu H, Brancati FL. Elevated A1C in adults without a history of diabetes in the U. S. Diabetes Care 2009;32:828-33.
20. Herranz L, Saez-de-Ibarra L, Grande C, Pallardo LF. Non-gly-cemic- dependent reduction of late pregnancy A1C levels in women with type 1 diabetes. Diabetes Care 2007;30:1579-80.
21. Szymezak J, Lavalard E, Martin M, Leroy N, Gillery P. Car-bamylated hemoglobin remains a critical issue in HbA1c measurements. Clin Chem Lab Med 2009;47:612-3.
22. Pani L, Korenda L, Meigs J, Driver C, Chamany S, Fox C, et al. Effect of aging on A1c levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004. Diabetes Care 2008;31:1991-6.
23. Lippi G, Montagnana M, Salvagno GL, Franchini M, Guidi GC. Glycaemic control in athletes. Int J Sports Med 2008;29:7-10.
24. Sawka MN, Convertino VA, Eichner ER, Schnieder SM, Young AJ. Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sci Sports Exerc 2000;32:332-48.
25. Sacks DB. The diagnosis of diabetes is changing: how implementation of hemoglobin A1c will impact clinical laboratories. Clin Chem 2009;55:1612-4.
26. Lenters-Westra E, Slingerland RJ. Hemoglobin A1c determination in the A1C-Derived Average Glucose (ADAG) study. Clin Chem Lab Med 2008;46:1617-23.
27. Goodall I, Colman PG, Schneider HG, McLean M, Barker G. Desirable performance standards for HbA (1c) analysis: precision, accuracy and standardisation: consensus statement of the Australasian Association of Clinical Biochemists (AACB), the Australian Diabetes Society (ADS), the Royal College of Pathologists of Australasia (RCPA), Endocrine Society of Australia (ESA), and the Australian Diabetes Educators Association (ADEA). Clin Chem Lab Med 2007;45:1083-97.
28. Mosca A, Branca MT, Carta M, Genna ML, Giorda CB, Ghi-delli R, et al., for GLAD Working Group (A1c delegates WG). Recommendations for the implementation of the international standardization of glycated hemoglobin in Italy. Clin Chem Lab Med 2010;48:623-6.
29. van't Riet E, Alssema M, Rijkelijkhuizen JM, Kostense PJ, Nij-pels G, Dekker JM. Relationship between A1C and glucose levels in the general Dutch population: the new Hoorn study. Diabetes Care 2010;33:61-6.
30. Carson AP, Reynolds K, Fonseca VA, Muntner P. Comparison of A1C and fasting glucose criteria to diagnose diabetes among U. S. adults. Diabetes Care 2010;33:95-7.
31. Kramer CK, Araneta MR, Barrett-Connor E. A1C and diabetes diagnosis: the Rancho Bernardo study. Diabetes Care 2010;33:101-3.
32. Bloomgarden ZT, Inzucchi SE, Karnieli E, Le Roith D. The proposed terminology 'A (1c) -derived average glucose' is inherently imprecise and should not be adopted. Diabetologia 2008;51:1111-4.
33. Nathan D, Turgeon H, Regan S. Relationship between glycated haemoglobin levels and mean glucose levels over time. Dia-betologia 2007;50:2239-44.
34. Diabetes Research in Children Network (DirecNet) Study Group. Relationship of A1c to glucose concentrations in children with type 1 diabetes: assessments by high-frequency glucose determinations by sensors. Diabetes Care 2008:31: 381-5.
35. Ginde AA, Cagliero E, Nathan DM, Camargo CA Jr. Point-of-care glucose and hemoglobin A1c in emergency department patients without known diabetes: implications for opportunistic screening. Acad Emerg Med 2008;15:1241-7.
36. Bruns DE, Boyd JC. Few point-of-care hemoglobin A1c assay methods meet clinical needs. Clin Chem 2010;56:4-6.