Post-illumination pupil response in subjects without ocular disease

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 5, 2010, Pages 2764-2769

  Kankipati, Laxmikanth ^a   Girkin, Christopher A ^b   Gamlin, Paul D ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BLUE LIGHT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; ILLUMINATION; MALE; MYDRIASIS; NORMAL HUMAN; PHOTOSTIMULATION; PRIORITY JOURNAL; PUPIL REFLEX; PUPILLOMETRY; RACE; RED LIGHT; SEX; STIMULUS RESPONSE; LIGHT; METABOLISM; MIDDLE AGED; PHOTORECEPTOR CELL; PHYSIOLOGY; PUPIL; RADIATION EXPOSURE; RETINA DISEASE; RETINA GANGLION CELL;

MELANOPSIN; SCOTOPSIN;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; LIGHT; MALE; MIDDLE AGED; PHOTORECEPTOR CELLS, VERTEBRATE; PUPIL; REFLEX, PUPILLARY; RETINAL DISEASES; RETINAL GANGLION CELLS; ROD OPSINS;

EID: 77952469592     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4717     Document Type: Article

References (26)

1. Alpern M, Campbell FW. The spectral sensitivity of the consensual light reflex. J Physiol. 1962;164:479-507.
2. Loewenfeld IE, Lowenstein O. The Pupil Anatomy, Physiology, and Clinical Applications. Vol. 1. Ames, IA: Iowa State University Press; 1993.
3. Gooley JJ, Lu J, Fischer D, Saper CB. A broad role for melanopsin in nonvisual photoreception. J Neurosci. 2003;23(18):7093-7106.
4. Gamlin PD, McDougal DH, Pokorny J, Smith VC, Yau KW, Dacey DM. Human and macaque pupil responses driven by melanopsincontaining retinal ganglion cells. Vision Res. 2007;47:946-954.
5. Lucas RJ, Douglas RH, Foster RG. Characterization of an ocular photopigment capable of driving pupillary constriction in mice. Nat Neurosci. 2001;4(6):621-626.
6. Oyster CW. The iris and the pupil. In: Oyster CW, ed. The Human Eye: Structure and Function. Sunderland, MA: Sinauer Associates; 1999:411-446.
7. Kardon RH. Anatomy and Physiology of the pupil. In: Walsh FB, Hoyt WF, eds. Clinical Neuro-ophthalmology. Baltimore: Williams & Wilkins; 1998:847-897.
8. Provencio I, Rodriguez IR, Jiang G, Hayes WP, Moreira EF, Rollag MD. A novel human opsin in the inner retina. J Neurosci. 2000; 20(2):600-605.
9. Hattar S, Liao HW, Takao M, Berson DM, Yau KW. Melanopsincontaining retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science. 2002;295(5557):1065-1070.
10. Kawasaki A, Kardon RH. Intrinsically photosensitive retinal ganglion cells. J Neuroophthalmol. 2007;27(3):195-204.
11. Dacey DM, Liao HW, Peterson BB, et al. Melanopsin-expressing ganglion cells in primate retina signal color and irradiance and project to the LGN. Nature. 2005;433(7027):749-754.
12. Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Sci Ophthalmol. 2002; 106(1):98-99.
13. Zaidi FH, Hull JT, Peirson SN, et al. Wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina. Curr Biol. 2007;17(24):2122-2128.
14. McDougal DH, Gamlin PD. The influence of intrinsically photosensitive retinal ganglion cells on the spectral sensitivity and response dynamics of the human pupillary light reflex. Vision Res. 2010; 50(1):72-87.
15. Ojima T, Tanabe T, Hangai M, Yu S, Morishita S, Yoshimura N. Measurement of retinal nerve fiber layer thickness and macular volume for glaucoma detection using optical coherence tomography. Jpn J Ophthalmol. 2007;51(3):197-203.
16. Beer RD, Macleod DI, Miller TP. The extended Maxwellian view (BIGMAX): a high-intensity, high-saturation color display for clinical diagnosis and vision research. Behav Res Methods. 2005;37(3):513-521.
17. Hammond CJ, Snieder H, Spector TD, Gilbert CE. Factors affecting pupil size after dilatation: the Twin Eye Study. Br J Ophthalmol. 2000;84(10):1173-1176.
18. Winn B, Whitaker D, Elliott DB, et al. Factors affecting lightadapted pupil size in normal human subjects. Invest Ophthalmol Vis Sci. 1994;35(3):1132-1137.
19. Pokorny J, Smith VC, Lutze M. Aging of the human lens. Appl Opt. 1987;26(8):1437-1440.
20. Newsome DA. After image and pupillary activity following strong light exposure. Vision Res. 1971;11(3):275-288.
21. Fatiou DF, Brozou CG, Tsiptsios DJ, et al. Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research. Electroyogr Clin Neurophysiol. 2007;47(1):11-22.
22. Herljevic M, Middleton B, Thapan K, et al. Light-induced melatonin suppression: age-related reduction in response to short wavelength. Exp Gerontol. 2005;40(3):237-242.
23. Higuchi S, Motohashi Y, Ishibashi K, et al. Influence of eye colors of Caucasians and Asians on suppression of melatonin secretion by light. Am J Physiol Regul Integr Comp Physiol. 2007;292(6): R2352-R2356.
24. Ijspeert J, deWaard PW, van den Berg TJ, et al. The intraocular stray light function in 129 healthy volunteers; dependence on angle, age and pigmentation. Vision Res. 1990;30:699-707.
25. Pickard GE, Baver SB, Ogilvie MD, Sollars PL. Light-induced fos expression in intrinsically photosensitive retinal ganglion cells in melanopsin knockout (opn4) mice. PLoS One. 2009;4(3):e4984.
26. Perez-Rico C, de la Villa P, Blanco R, et al. Alterations in nocturnal melatonin levels in patients with optic neuropathies (in Spanish). Arch Soc Esp Oftalmol. 2009;84(5):251-257.