P53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control

Oncogene

Volumn 29, Issue 19, 2010, Pages 2864-2876

  Hsu, F F ^a,b   Lin, T Y ^b   Chen, J Y ^b   Shieh, S Y ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Cell cycle checkpoint; LIMK2; P53

Indexed keywords

ACTIN; COFILIN; PHOSPHOTRANSFERASE; PROTEIN LIMK2A; PROTEIN LIMK2B; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CYTOKINESIS; DNA DAMAGE; DOWN REGULATION; ESOPHAGUS CANCER; HELA CELL; PLOIDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; THYROID CANCER; UPREGULATION;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; CELL CYCLE; CELL PROLIFERATION; CYTOKINESIS; DNA DAMAGE; G2 PHASE; HELA CELLS; HUMANS; LIM KINASES; NEOPLASMS; PHOSPHORYLATION; PLOIDIES; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 77952430886     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.40     Document Type: Article

References (39)

1. Abe H, Obinata T, Minamide LS, Bamburg JR. (1996). Xenopus laevis actin-depolymerizing factor/cofilin: a phosphorylation-regulated protein essential for development. J Cell Biol 132: 871-885.
2. Amano T, Kaji N, Ohashi K, Mizuno K. (2002). Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis. J Biol Chem 277: 22093-22102.
3. Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K. (2001). LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem J 354: 149-159.
4. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O et al. (1998). Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393: 805-809.
5. Bode AM, Dong Z. (2004). Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 4: 793-805.
6. Croft DR, Olson MF. (2006). The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol 26: 4612-4627.
7. Gadea G, de Toledo M, Anguille C, Roux P. (2007). Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices. J Cell Biol 178: 23-30.
8. Gadea G, Lapasset L, Gauthier-Rouviere C, Roux P. (2002). Regulation of Cdc42-mediated morphological effects: a novel function for p53. EMBO J 21: 2373-2382.
9. Goyal P, Pandey D, Behring A, Siess W. (2005). Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283. J Biol Chem 280: 27569-27577.
10. Gunsalus KC, Bonaccorsi S, Williams E, Verni F, Gatti M, Goldberg ML. (1995). Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. J Cell Biol 131: 1243-1259.
11. Guo F, Gao Y, Wang L, Zheng Y. (2003). p19ARF-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities. J Biol Chem 278: 14414-14419.
12. Harms K, Nozell S, Chen X. (2004). The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 61: 822-842.
13. Hotulainen P, Paunola E, Vartiainen MK, Lappalainen P. (2005). Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell 16: 649-664.
14. Ikebe C, Ohashi K, Fujimori T, Bernard O, Noda T, Robertson EJ et al. (1997). Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts. Genomics 46: 504-508.
15. Jetten AM. (2009). Retinoid-related orphan receptors (RORs):critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal 7: e003.
16. Lavin MF, Gueven N. (2006). The complexity of p53 stabilization and activation. Cell Death Differ 13: 941-950.
17. Lee S, Helfman DM. (2004). Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/Cofilin pathway. J Biol Chem 279: 1885-1891.
18. Li Z, Wang C, Jiao X, Lu W, Fu M, Quong AA et al. (2006). Cyclin D1 regulates cellular migration through the inhibition of throm-bospondin 1 and ROCK signaling. Mol Cell Biol 26: 4240-4256.
19. Lu Y, Yi Y, Liu P, Wen W, James M, Wang D et al. (2007). Common human cancer genes discovered by integrated gene-expression analysis. PLoS ONE 2: e1149.
20. Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A et al. (1999). Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285: 895-898.
21. Murray-Zmijewski F, Slee EA, Lu X. (2008). A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol 9: 702-712.
22. Nomoto S, Tatematsu Y, Takahashi T, Osada H. (1999). Cloning and characterization of the alternative promoter regions of the human LIMK2 gene responsible for alternative transcripts with tissue-specific expression. Gene 236: 259-271.
23. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. (2000). Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275: 3577-3582.
24. Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S et al. (1995). Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. J Biol Chem 270: 31321-31330.
25. Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC, Hainaut P. (2002). The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat 19: 607-614.
26. Olsson A, Manzl C, Strasser A, Villunger A. (2007). How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? Cell Death Differ 14: 1561-1575.
27. Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP et al. (2006). RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol 16: 2466-2472.
28. Osada H, Hasada K, Inazawa J, Uchida K, Ueda R, Takahashi T et al. (1996). Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation. Biochem Biophys Res Commun 229: 582-589.
29. Ou Y-H, Chung P-H, Hsu F-F, Sun T-P, Chang W-Y, Shieh S-Y. (2007). The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J 26: 3968-3980.
30. Riley T, Sontag E, Chen P, Levine A. (2008). Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9: 402-412.
31. Sahai E, Olson MF, Marshall CJ. (2001). Cross-talk between Ras and Rho signaling pathways in transformation favours proliferation and increased motility. EMBO J 20: 755-766.
32. Scott RW, Olson MF. (2007). LIM kinases: function, regulation and association with human disease. J Mol Med 85: 555-568.
33. Smolich B, Vo M, Buckley S, Plowman G, Papkoff J. (1997). Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains. J Biochem 121: 382-388.
34. Sumi T, Matsumoto K, Nakamura T. (2001). Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J Biol Chem 276: 670-676.
35. Sumi T, Matsumoto K, Takai Y, Nakamura T. (1999). Cofilin phosphorylation and actin cytoskeletal dynamics regulated by Rho-and Cdc42-activated LIM-kinase 2. J Cell Biol 147: 1519-1532.
36. Takahashi T, Koshimizu U, Abe H, Ohinata T, Nakamura T. (2001). Functional involvement of Xenopus LIM kinases in progression of oocyte maturation. Dev Biol 229: 554-567.
37. Toledo F, Wahl GM. (2006). Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923.
38. Vardouli L, Moustakas A, Stournaras C. (2005). LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta. J Biol Chem 280: 11448-11457.
39. Zhu Y, McAvoy S, Kuhn R, Smith DI. (2006). RORA, a large common fragile site gene, is involved in cellular stress response. Oncogene 25: 2901-2908.