Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154

Journal of Hepatology

Volumn 52, Issue 6, 2010, Pages 800-811

  Mueller, Mareike ^a   Spangenberg, Hans Christian ^a   Kersting, Nadine ^a   Altay, Tayibe ^a   Blum, Hubert E ^a   Klenerman, Paul ^b   Thimme, Robert ^a   Semmo, Nasser ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD154; CD4+ T cells; Hepatitis C virus; IFN ; Proliferation

Indexed keywords

CD40 LIGAND; GAMMA INTERFERON; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; NONSTRUCTURAL PROTEIN 5;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERFERON PRODUCTION; LIVER HISTOLOGY; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; UPREGULATION;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODIES, BLOCKING; BIOPSY; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL DIVISION; CELLS, CULTURED; CONVALESCENCE; FEMALE; FLOW CYTOMETRY; HEPATITIS C ANTIGENS; HEPATITIS C, CHRONIC; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOMAGNETIC SEPARATION; INTERFERON-GAMMA; LIVER; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; UP-REGULATION;

EID: 77952430522     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.12.038     Document Type: Article

References (35)

1. Day C.L., Lauer G.M., Robbins G.K., McGovern B., Wurcel A.G., Gandhi R.T., et al. Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection. J Virol 76 (2002) 12584-12595
2. Gerlach J.T., Diepolder H.M., Jung M.C., Gruener N.H., Schraut W.W., Zachoval R., et al. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology 117 (1999) 933-941
3. Lechner F., Wong D.K., Dunbar P.R., Chapman R., Chung R.T., Dohrenwend P., et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 191 (2000) 1499-1512
4. Rosen H.R., Miner C., Sasaki A.W., Lewinsohn D.M., Conrad A.J., Bakke A., et al. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology 35 (2002) 190-198
5. Takaki A., Wiese M., Maertens G., Depla E., Seifert U., Liebetrau A., et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 6 (2000) 578-582
6. Gerlach J.T., Ulsenheimer A., Gruner N.H., Jung M.C., Schraut W., Schirren C.A., et al. Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins. J Virol 79 (2005) 12425-12433
7. Wertheimer A.M., Miner C., Lewinsohn D.M., Sasaki A.W., Kaufman E., and Rosen H.R. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology 37 (2003) 577-589
8. Diepolder H.M., Zachoval R., Hoffmann R.M., Wierenga E.A., Santantonio T., Jung M.C., et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346 (1995) 1006-1007
9. Bukh J., Forns X., Emerson S.U., and Purcell R.H. Studies of hepatitis C virus in chimpanzees and their importance for vaccine development. Intervirology 44 (2001) 132-142
10. Shoukry N.H., Sidney J., Sette A., and Walker C.M. Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections. J Immunol 172 (2004) 483-492
11. Woollard D.J., Grakoui A., Shoukry N.H., Murthy K.K., Campbell K.J., and Walker C.M. Characterization of HCV-specific Patr class II restricted CD4+ T cell responses in an acutely infected chimpanzee. Hepatology 38 (2003) 1297-1306
12. Day C.L., Seth N.P., Lucas M., Appel H., Gauthier L., Lauer G.M., et al. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest 112 (2003) 831-842
13. Lucas M., Ulsenheimer A., Pfafferot K., Heeg M.H.J., Gaudieri S., Grüner N., et al. PLoS ONE 2 (2007) e649
14. Mackey M.F., Barth Jr. R.J., and Noelle R.J. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J Leukoc Biol 63 (1998) 418-428
15. Frentsch M., Arbach O., Kirchhoff D., Moewes B., Worm M., Rothe M., et al. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 11 (2005) 1118-1124
16. Chattopadhyay P.K., Yu J., and Roederer M. A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med 11 (2005) 1113-1117
17. Thimme R., Neagu M., Boettler T., Neumann-Haefelin C., Kersting N., Geissler M., et al. Comprehensive analysis of the alpha-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma. Hepatology 48 (2008) 1821-1833
18. Spangenberg H.C., Viazov S., Kersting N., Neumann-Haefelin C., McKinney D., Roggendorf M., et al. Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. Hepatology 42 (2005) 828-837
19. Semmo N., Krashias G., Willberg C., and Klenerman P. Analysis of the relationship between cytokine secretion and proliferative capacity in hepatitis C virus infection. J Viral Hepat 14 (2007) 492-502
20. Semmo N., Day C.L., Ward S.M., Lucas M., Harcourt G., Loughry A., et al. Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection. Hepatology 41 (2005) 1019-1028
21. Barnes E., Salio M., Cerundolo V., Medlin J., Murphy S., Dusheiko G., et al. Impact of alpha interferon and ribavirin on the function of maturing dendritic cells. Antimicrob Agents Chemother 48 (2004) 3382-3389
22. Semmo N., Barnes E., Taylor C., Kurtz J., Harcourt G., Smith N., et al. T-cell responses and previous exposure to hepatitis C virus in indeterminate blood donors. Lancet 365 (2005) 327-329
23. Barnes E., Harcourt G., Brown D., Lucas M., Phillips R., Dusheiko G., et al. The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection. Hepatology 36 (2002) 743-754
24. Barnes E., Ward S.M., Kasprowicz V.O., Dusheiko G., Klenerman P., and Lucas M. Ultra-sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8+ T cells. Eur J Immunol 34 (2004) 1570-1577
25. Sugimoto K., Ikeda F., Stadanlick J., Nunes F.A., Alter H.J., and Chang K.M. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 38 (2003) 1437-1448
26. Ulsenheimer A., Gerlach J.T., Gruener N.H., Jung M.C., Schirren C.A., Schraut W., et al. Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C. Hepatology 37 (2003) 1189-1198
27. Urbani S., Amadei B., Tola D., Pedrazzi G., Sacchelli L., Cavallo M.C., et al. Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment. J Hepatol 48 (2008) 548-558
28. Godkin A., Jeanguet N., Thursz M., Openshaw P., and Thomas H. Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients. Eur J Immunol 31 (2001) 1438-1446
29. Eckels D.D., Zhou H., Bian T.H., and Wang H. Identification of antigenic escape variants in an immunodominant epitope of hepatitis C virus. Int Immunol 11 (1999) 577-583
30. Minutello M, Pileri P, Unutmaz D, Censini S, Kuo G, Houghton M, et al. Compartmentalization of T lymphocytes to the site of disease: intrahepatic T cells specific for the NS4 protein of HCV in patients with chronic hepatitis C. J Exp Med 1993;178:17-25.
31. Penna A., Missale G., Lamonaca V., Pilli M., Mori C., Zanelli P., et al. Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: functional characterization in patients with chronic hepatitis C. Hepatology 35 (2002) 1225-1236
32. Schirren C.A., Jung M.C., Gerlach J.T., Worzfeld T., Baretton G., Mamin M., et al. Liver-derived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma. Hepatology 32 (2000) 597-603
33. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., et al. Heterologous protection against influenza by injection of DNA encoding a viral protein [see comments]. Science 259 (1993) 1745-1749
34. Tsai S.L., Liaw Y.F., Chen M.H., Huang C.Y., and Kuo G.C. Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology 25 (1997) 449-458
35. Neumann-Haefelin C., Timm J., Spangenberg H.C., Wischniowski N., Nazarova N., Kersting N., et al. Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology 47 (2008) 1824-1836