Identifying candidate allogeneic NK-cell donors for hematopoietic stem-cell transplantation based on functional phenotype

Leukemia

Volumn 24, Issue 5, 2010, Pages 1059-1062

  Hurton, L V ^a   Siddik, R I ^a   Singh, H ^a   Olivares, S ^a   Rabinovich, B A ^b   Tian, R ^c   Mojsilovic, D ^c   Hildebrand, W ^c   Lee, D A ^a   Kelly, S S ^a   Champlin, R ^b   Shpall, E J ^b   Fernandez Via M ^b   Cooper, L J N ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; CYTOLYSIS; DONOR SELECTION; GRAFT RECIPIENT; HUMAN; HUMAN CELL; LETTER; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL;

EID: 77952430182     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.19     Document Type: Letter

References (9)

1. Ruggeri L, Mancusi A, Burchielli E, Capanni M, Carotti A, Aloisi T et al. NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation. Blood Cells Mol Dis 2008; 40: 84-90.
2. Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005; 105: 3051-3057.
3. Locatelli F, Pende D, Maccario R, Mingari MC, Moretta A, Moretta L. Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference. Clin Immunol 2009; 133: 171-178.
4. NCT00698009 http://clinicaltrials.gov. Last updated: November 16, 2009
5. NCT00941928 http://clinicaltrials.gov. Last updated: January 6, 2010.
6. Ljunggren HG, Kärre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 1990; 11: 237-244.
7. Ljunggren HG, Malmberg KJ. Prospects for the use of NK cells in immunotherapy of human cancer. Nat Rev Immunol 2007; 7: 329-339.
8. Velardi A, Ruggeri L, Moretta A, Moretta L. NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol 2002; 23: 438-444.
9. Shimizu Y, Geraghty DE, Koller BH, Orr HT, DeMars R. Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells. Proc Natl Acad Sci USA 1988; 85: 227-231.