Disability, more than multimorbidity, was predictive of mortality among older persons aged 80 years and older

Journal of Clinical Epidemiology

Volumn 63, Issue 7, 2010, Pages 752-759

  Landi, Francesco ^a   Liperoti, Rosa ^a   Russo, Andrea ^a   Capoluongo, Ettore ^a   Barillaro, Christian ^a   Pahor, Marco ^b   Bernabei, Roberto ^a   Onder, Graziano ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Disability; Frail elderly; Health care; Longevity; Mortality; Multimorbidity

Indexed keywords

AGED; ARTICLE; BLOOD SAMPLING; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DISABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SURVIVAL RATE;

AGED, 80 AND OVER; AGING; CAUSE OF DEATH; DISABLED PERSONS; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH STATUS INDICATORS; HUMANS; ITALY; LONGEVITY; MALE; MORBIDITY; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS; SURVIVAL RATE;

EID: 77952428000     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2009.09.007     Document Type: Article

References (42)

1. Fried L.P., Ferrucci L., Darer J., Williamson J.D., and Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59 (2004) 255-263
2. Tooth L., Hockey R., Byles J., and Dobson A. Weighted multimorbidity indexes predicted mortality, health service use, and health-related quality of life in older women. J Clin Epidemiol 61 (2008) 151-159
3. de Groot V., Beckerman H., Lankhorst G., and Bouter L. How to measure comorbidity: a critical review of available methods. J Clin Epidemiol 57 (2004) 323-332
4. Landi F., Onder G., Cesari M., Barillaro C., Lattanzio F., Carbonin P.U., et al. Comorbidity and social factors predicted hospitalization in frail elderly patients. J Clin Epidemiol 57 (2004) 832-836
5. Groll D.L., To T., Bombardier C., and Wright J.G. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol 58 (2005) 595-602
6. Yokota C., Minematsu K., Hasegawa Y., and Yamaguchi T. Long-term prognosis, by stroke subtypes, after a first-ever stroke: a hospital-based study over a 20-year period. Cerebrovasc Dis 18 (2004) 111-116
7. Gijsen R., Hoeymans N., Schellevis F.G., Ruwaard D., Satariano W.A., and van den Bos G.A. Causes and consequences of comorbidity: a review. J Clin Epidemiol 54 (2001) 661-674
8. Fried L.P., Bandeen-Roche K., Kasper J.D., and Guralnik J.M. Association of comorbidity with disability in older women: the Women's Health and Aging Study. J Clin Epidemiol 52 (1999) 27-37
9. Cesari M., Onder G., Russo A., Zamboni V., Barillaro C., Ferrucci L., et al. Comorbidity and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study). Gerontology 52 (2006) 24-32
10. World Health Organization. International Classification of Functioning Disability and Health (ICF) (2001), World Health Organization, Geneva, Switzerland
11. Harris T., Kovar M.G., Suzman R., et al. Longitudinal study of physical ability in the oldest-old. Am J Public Health 79 (1989) 698-702
12. Guralnik J.M., Ferrucci L., Simonsick E.M., Salive M.E., and Wallace R.B. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332 (1995) 556-561
13. Fried L.P., Kronmal R.A., Newman A.B., Bild D.E., Mittelmark M.B., Polak J.F., et al. Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA 279 (1998) 585-592
14. Stuck A.E., Walthert J.M., Nikolaus T., Bula C.J., Hohmann C., and Beck J.C. Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med 48 (1999) 445-469
15. Perkins A.J., Kroenke K., Unutzer J., Katon W., Williams J.W., Hope C., et al. Common comorbidity scales were similar in their ability to predict health care costs and mortality. J Clin Epidemiol 57 (2004) 1040-1048
16. Fortin M., Bravo G., Hudon C., Vanasse A., and Lapointe L. Prevalence of multimorbidity among adults seen in family practice. Ann Fam Med 3 (2005) 223-228
17. Marengoni A., von Strauss E., Rizzuto D., Winblad B., and Fratiglioni L. The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med 265 (2009) 288-295
18. Fortin M., Soubhi H., Hudon C., Bayliss E.A., and van den Akker M. Multimorbidity's many challenges. BMJ 334 (2007) 1016-1017
19. Landi F., Russo A., Cesari M., Barillaro C., Onder G., Zamboni V., et al. The ilSIRENTE study: a prospective cohort study on persons aged 80 years and older living in a mountain community of Central Italy. Aging Clin Exp Res 17 (2005) 486-493
20. Morris J.N., Fries B.E., and Meher D.R. MDS Cognitive Performance Scale. J Gerontol A Biol Sci Med Sci 49 (1994) M174-M182
21. Morris J.N., Fries B.E., Bernabei R., Ikegami N., Gilgen R., and Steel K. RAI-home care assessment manual (1996), InterRAI Coporation, Washington, DC
22. Morris J.N., Fries B.E., Steel K., Ikegami N., Bernabei R., Carpenter G.I., et al. Comprehensive clinical assessment in community setting: applicability of the MDS-HC. J Am Geriatr Soc 45 (1997) 1017-1024
23. Landi F., Tua E., Onder G., Carrara B., Sgadari A., Rinaldi C., et al. Minimum data set for home care: a valid instrument to assess frail older people living in the community. Med Care 38 (2000) 1184-1190
24. Ferrucci L., Bandinelli S., Benvenuti E., Di Iorio A., Macchi C., and Harris T.B. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 48 (2000) 1618-1625
25. Rothman K.J., and Greenland S. Concepts of interaction. In: Rothman K.J., and Greenland S. (Eds). Modern Epidemiology. 2nd edition (1998), Lippincott-Raven Publishers, Philadelphia, PA 329-342
26. Hallqvist J., Ahlbom A., Diderichsen F., and Reuterwall C. How to evaluate interaction between causes: a review of practices in cardiovascular epidemiology. J Intern Med 239 (1996) 377-382
27. Seeman T.E., Charpentier P.A., Berkman L.F., Tinetti M.E., Guralnik J.M., Albert M., et al. Predicting changes in physical performance in a high-functioning elderly cohort: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 49 (1994) M97-108
28. Menotti A., Mulder I., Nissinen A., Giampaoli S., Feskens E.J., and Kromhout D. Prevalence of morbidity and multimorbidity in elderly male populations and their impact on 10-year all-cause mortality: the FINE study (Finland, Italy, Netherlands, Elderly). J Clin Epidemiol 54 (2001) 680-686
29. Fillenbaum G.G., Pieper C.F., Cohen H.J., Cornoni-Huntley J.C., and Guralnik J.M. Comorbidity of five chronic health conditions in elderly community residents: determinants and impact on mortality. J Gerontol A Biol Sci Med Sci 55 (2000) M84-M89
30. Di Bari M., Virgillo A., Matteuzzi D., Inzitari M., Mazzaglia G., Pozzi C., et al. Predictive validity of measures of comorbidity in older community dwellers: the Insufficienza Cardiaca negli Anziani Residenti a Dicomano Study. J Am Geriatr Soc 54 (2006) 210-216
31. Ferrucci L., Guralnik J.M., Baroni A., Tesi G., Antonini E., and Marchionni N. Value of combined assessment of physical health and functional status in community-dwelling aged: a prospective study in Florence, Italy. J Gerontol A Biol Sci Med Sci 46 (1991) M52-M56
32. Ho S.C., Woo J., Yuen Y.K., Sham A., and Chan S.G. Predictors of mobility decline: the Hong Kong old-old study. J Gerontol A Biol Sci Med Sci 52 (1997) M356-M362
33. Ferrucci L., Guralnik J.M., Simonsick E., Salive M.E., Corti C., and Langlois J. Progressive versus catastrophic disability: a longitudinal view of the disablement process. J Gerontol A Biol Sci Med Sci 51 (1996) M123-M130
34. Strawbridge W.J., Kaplan G.A., Camacho T., and Cohen R.D. The dynamics of disability and functional change in an elderly cohort: results from the Alameda County Study. J Am Geriatr Soc 40 (1992) 799-806
35. Lubitz J., Cai L., Kramarow E., and Lentzner H. Health, life expectancy, and health care spending among the elderly. N Engl J Med 349 (2003) 1048-1055
36. Inouye S.K., Peduzzi P.N., Robison J.T., Hughes J.S., Horwitz R.I., and Concato J. Importance of functional measures in predicting mortality among older hospitalized patients. JAMA 279 (1998) 1187-1193
37. Antonelli Incalzi R., Capparella O., Gemma A., Landi F., Bruno E., Di Meo F., et al. The interaction between age and comorbidity contributes to predicting the mortality of geriatric patients in the acute-care hospital. J Intern Med 242 (1997) 291-298
38. Landi F., Cesari M., Onder G., Lattanzio F., Gravina E.M., and Bernabei R. Physical activity and mortality in frail, community-living elderly patients. J Gerontol A Biol Sci Med Sci 59 (2004) 833-837
39. Nusselder W.J., Looman W.N., and Mackenbach J.P. Nondisease factors affected trajectories of disability in a prospective study. J Clin Epidemiol 58 (2005) 484-494
40. Bernabei R., Landi F., Onder G., Liperoti R., and Gambassi G. Second and third generation assessment instruments: the birth of standardization in geriatric care. J Gerontol A Biol Sci Med Sci 63 (2008) 308-313
41. Rockwood K., Howlett S., Stadnyk K., Carver D., Powell C., and Stolee P. Responsiveness of goal attainment scaling in a randomized controlled trial of comprehensive geriatric assessment. J Clin Epidemiol 56 (2003) 736-743
42. Landi F., Onder G., Russo A., Tabaccanti S., Rollo R., Federici S., et al. A new model of integrated home care for the elderly: impact on hospital use. J Clin Epidemiol 54 (2001) 968-970