Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: Implications for drug-induced agranulocytosis

Chemical Research in Toxicology

Volumn 23, Issue 5, 2010, Pages 880-887

  Siraki, Arno G ^a   Jiang, Jinjie ^b   Mason, Ronald P ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROANILINE; 2 NITROANILINE; 2,4 DICHLOROANILINE; 2,4 DIMETHOXYANILINE; 2,4 DIMETHYLANILINE; 2,6 DICHLOROANILINE; 2,6 DIMETHYLANILINE; 3 CHLOROANILINE; 3 NITROANILINE; 3,4 DICHLOROANILINE; 3,4 DIMETHYLANILINE; 4 AMINOBENZONITRILE; 4 AMINOVERATROLE; 4 CHLORO ORTHO TOLUIDINE; 4 FLUOROANILINE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; AMINOGLUTETHIMIDE; AMINOSALICYLIC ACID; ANILINE; ANILINE DERIVATIVE; ANISIDINE; BENZONITRILE; ETHYLANILINE; FREE RADICAL; HYDROGEN PEROXIDE; MYELOPEROXIDASE; PROCAINAMIDE; PROTEIN DERIVATIVE; TOLUIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AGRANULOCYTOSIS; ARTICLE; CHEMICAL ANALYSIS; ELECTRON SPIN RESONANCE; HUMAN; IMMUNOASSAY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AGRANULOCYTOSIS; ANILINE COMPOUNDS; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; PEROXIDASE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952398669     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900432d     Document Type: Article

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