Small-molecule affinity ligands for protein purification: Combined computational enrichment and automated in-line screening of an optically encoded library

Angewandte Chemie - International Edition

Volumn 49, Issue 20, 2010, Pages 3477-3480

  Rasmussen, Jakob E ^a,b   Schiødt, Christine B ^a   Christensen, Søren F ^a   Nørskov Lauritsen, Leif ^a   Meldal, Morten ^c   St Hilaire, Phaedria M ^a   Jensen, Knud J ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c CARLSBERG LABORATORY   (Denmark)

Author keywords

Affinity chromatography; Combinatorial chemistry; Hormones; Protein protein interactions; Virtual screening

Indexed keywords

AFFINITY LIGANDS; AUTOMATED SCREENING; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; HUMAN GROWTH HORMONE; IN-LINE; PROTEIN PURIFICATION; PROTEIN TARGETS; PROTEIN-PROTEIN INTERACTIONS; SINGLE-STEP PURIFICATION; SMALL MOLECULES; VIRTUAL SCREENING;

AFFINITY CHROMATOGRAPHY; BIOASSAY; BIOCHIPS; ENDOCRINOLOGY; HORMONES; LIGANDS; PURIFICATION;

PROTEINS;

HUMAN GROWTH HORMONE; LIGAND;

ARTICLE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION; LABORATORY AUTOMATION; MOLECULAR LIBRARY; PROTEIN TERTIARY STRUCTURE;

AUTOMATION, LABORATORY; COMPUTATIONAL BIOLOGY; HUMAN GROWTH HORMONE; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES;

EID: 77952391552     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200906602     Document Type: Article

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