Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus

Molecular Medicine Reports

Volumn 3, Issue 3, 2010, Pages 509-513

  Kim, Ok Joon ^a   Kim, Un Kyung ^b   Oh, Seung Hun ^a   Cho, Yong Wook ^a   Oh, Kyung Im ^a   Oh, Doyeun ^a   Park, Young Seok ^c   Kim, Nam Keun ^a  

^a CHA University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Diabetes mellitus; Endothelial nitric oxide synthase; Haplotype; Ischemic stroke; Polymorphism

Indexed keywords

ANTIHYPERTENSIVE AGENT; CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCINE; INSULIN; ORAL ANTIDIABETIC AGENT; THREONINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; HYPERTENSION; KOREA; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 77952366372     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr_00000289     Document Type: Article

References (24)

1. Murray CJ and Lopez AD: Mortality by cause for eight regions of the world: global burden of disease study. Lancet 349: 1269-1276, 1997. (Pubitemid 27192468)
2. Voetsch B and Loscalzo J: Genetic determinants of arterial thrombosis. Arterioscler Thromb Vasc Biol 24: 216-229, 2004.
3. Jorgensen H, Nakayama H, Raaschou HO and Olsen TS: Stroke in patients with diabetes. The Copenhagen Stroke Study. Stroke 25: 1977-1984, 1994.
4. Iso H, Imano H, Kitamura A, Sato S, Naito Y, Tanigawa T, Ohira T, Yamagishi K, Iida M and Shimamoto T: Type 2 diabetes and risk of non-embolic ischaemic stroke in Japanese men and women. Diabetologia 47: 2137-2144, 2004.
5. Janghorbani M, Hu FB, Willett Wc, Li TY, Manson Je, Logroscino G and Rexrode KM: Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes: the Nurses' Health Study. Diabetes Care 30: 1730-1735, 2007. (Pubitemid 47036344)
6. Garg UC and Hassid A: Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83: 1774-1777, 1989.
7. Moncada S: The L-arginine: nitric oxide pathway, cellular transduction and immunological roles. Adv Second Messenger Phosphoprotein res 28: 97-99, 1993.
8. Wolf A, Zalpour C, Theilmeier G, Wang BY, Ma A, Anderson B, Tsao PS and Cooke JP: Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 29: 479-485, 1997. (Pubitemid 27116086)
9. McVeigh G, Brennan G, Johnston D, McDermott BJ, McGrath LT, Henry WR, Andrews JW and Hayes JR: Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35: 771-776, 1992.
10. McVeigh G, Brennan G, Hayes JR and Johnston D: Primary nitrate tolerance in diabetes mellitus. Diabetologia 37: 115-117, 1994. (Pubitemid 24044717)
11. Markus HS, Lythgoe DJ, Ostegaard L, O'Sullivan M and Williams SC: Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. J Neurol Neurosurg Psychiatry 69: 48-53, 2000. (Pubitemid 30410414)
12. Adachi T and Wang XL: Association of extracellular-superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase polymorphism. FEBS lett 433: 166-168, 1998. (Pubitemid 28386751)
13. Hassan A, Gormley K, O'Sullivan M, Knight J, Sham P, Vallance P, Bamford J and Markus H: Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease. Stroke 35: 654-659, 2004. (Pubitemid 38280836)
14. Yamaguchi S, Yamada Y, Metoki N, Yoshida H, Satoh K, Ichihara S, Kato K, Kameyama T, Yokoi K, Matsuo H, Segawa T, Watanabe S and Nozawa Y: Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. int J Mol Med 18: 871-883, 2006.
15. Berger K, F Stogbauer F, Stoll M, Wellmann J, Huge A, Cheng S, Kessler C, John U, Assmann G, Ringelstein EB and Funke H: The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet 121: 169-178, 2007.
16. Cheng J, Liu J, Li X, Yu L, Peng J, Zhang R, Geng Y and Nie S: Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: a case-control study in a Chinese population. Clin Chim Acta 392: 46-51, 2008.
17. Yamada Y, Kato K, Oguri M, Yoshida T, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M and Nozawa Y: Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. Int J Mol Med 21: 801-808, 2008.
18. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr and Roccella EJ: The seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure: the JNC 7 report. JAMA 289: 2560-2572, 2003. (Pubitemid 37430158)
19. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 27: S5-S9, 2004.
20. Bersano A, Ballabio E, Bresolin N and Candelise L: Genetic polymorphisms for the study of multifactorial stroke. Hum Mutat 29: 776-795, 2008. (Pubitemid 351794129)
21. Sun Q, Ma J, Campos H, Hankinson SE, Manson JE, Stampfer MJ, Rexrode KM, Willett WC and Hu FB: A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 115: 1858-1865, 2007.
22. Song J, Yoon Y, Park Ku, Park J, Hong YJ, Hong SH and Kim JQ: Genotype-specific influence on nitric oxide synthase gene expression, protein concentrations, and enzyme activity in cultured human endothelial cells. Clin Chem 49: 847-852, 2003.
23. Yoon S, Shin C, Park HY, Moon J, Kim E, Kim HT, Min J, Jo SA and Jo I: endothelial nitric oxide synthase gene is associated with vessel stenosis in Korean population. Clin Clin Chim Acta 353: 177-185, 2005.
24. Ohtoshi K, Yamasaki Y, Gorogawa S, Hayaishi-Okano R, Node K, Matsuhisa M, Kajimoto Y and Hori M: Association of (-)786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance. Diabetologia 45: 1594-1601, 2002. (Pubitemid 35352054)