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Volumn 54, Issue 1, 2010, Pages 7-19

Trends in development of the influenza vaccine with broader cross-protection

Author keywords

Adjuvants; Conserved antigens; Immune response; Influenza a virus; Live vaccine; Vaccine efficacy

Indexed keywords

ADENOVIRUS VECTOR; ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; CHOLERA TOXIN B SUBUNIT; DNA VACCINE; EPITOPE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOLOGICAL ADJUVANT; INACTIVATED VACCINE; INFLUENZA VACCINE; LIVE VACCINE; MEMBRANE PROTEIN; MEMBRANE PROTEIN M2; MIFAMURTIDE; NEUTRALIZING ANTIBODY; RECOMBINANT VACCINE; SUBUNIT VACCINE; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ; VIRUS PROTEIN; VIRUS SIALIDASE; HEMAGGLUTININ, HUMAN INFLUENZA A VIRUS; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS ANTIBODY;

EID: 77952318056     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2010_01_7     Document Type: Review
Times cited : (10)

References (123)
  • 2
    • 33749430380 scopus 로고    scopus 로고
    • A novel approach to vaccine design Epitope-based vaccines
    • Arnon R. (2006) A novel approach to vaccine design Epitope-based vaccines. Bti. 18, 10-13.
    • (2006) Bti , vol.18 , pp. 10-13
    • Arnon, R.1
  • 3
    • 0021323780 scopus 로고
    • Immunogenic properties of the small chain HA2 of the haemagglutinin of influenza viruses
    • Becht H, Huang RT, Fleischer B, Boschek CB, Rott R. (1984) Immunogenic properties of the small chain HA2 of the haemagglutinin of influenza viruses. J. Gen. Virol. 65, 173-183.
    • (1984) J. Gen. Virol. , vol.65 , pp. 173-183
    • Becht, H.1    Huang, R.T.2    Fleischer, B.3    Boschek, C.B.4    Rott, R.5
  • 4
    • 33750601397 scopus 로고    scopus 로고
    • Towards an epitope-based vaccine for influenza
    • Ben-Yedidia T, Arnon R. (2005) Towards an epitope-based vaccine for influenza. Human vaccine 1, 95-101.
    • (2005) Human vaccine , vol.1 , pp. 95-101
    • Ben-Yedidia, T.1    Arnon, R.2
  • 5
    • 0000652860 scopus 로고
    • Epithelial and hepatobiliary transport of polymeric immunoglobulins
    • Ogra PL, Lamm ME, McGhee JR, Mestecky J, Strober W, Bienenstock J (Eds), Academic Press, San Diego, California
    • Brandtzaeg P, Krajci P, Lamm ME, Kaetzl CZ. (1994) Epithelial and hepatobiliary transport of polymeric immunoglobulins. In Ogra PL, Lamm ME, McGhee JR, Mestecky J, Strober W, Bienenstock J (Eds) Handbook of Mucosal Immunology. Academic Press, San Diego, California, pp. 113-126.
    • (1994) Handbook of Mucosal Immunology , pp. 113-126
    • Brandtzaeg, P.1    Krajci, P.2    Lamm, M.E.3    Kaetzl, C.Z.4
  • 8
    • 0029558245 scopus 로고
    • A soluble domain of the membrane-anchoring chain of the influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low pH-induced conformation
    • Chen J, Wharton SA, Weisserhorn W, Calder L, Hughson FM, Skehel JJ, Wiley DC. (1995) A soluble domain of the membrane-anchoring chain of the influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low pH-induced conformation. Proc. Natl. Acad. Sci. USA 92, 12205-12209.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12205-12209
    • Chen, J.1    Wharton, S.A.2    Weisserhorn, W.3    Calder, L.4    Hughson, F.M.5    Skehel, J.J.6    Wiley, D.C.7
  • 9
    • 0033782851 scopus 로고    scopus 로고
    • Epidermal immunization by a nedele-free powder delivery technology Immunogenicity of influenza vaccine and protection in mice
    • Chen D, Endres RL, Erickson CA, Weis KF, McGregor MW, Kawaoka Y, Payne LG. (2000) Epidermal immunization by a nedele-free powder delivery technology Immunogenicity of influenza vaccine and protection in mice. Nat. Med. 6, 1187-1190.
    • (2000) Nat. Med. , vol.6 , pp. 1187-1190
    • Chen, D.1    Endres, R.L.2    Erickson, C.A.3    Weis, K.F.4    McGregor, M.W.5    Kawaoka, Y.6    Payne, L.G.7
  • 11
    • 58749101350 scopus 로고    scopus 로고
    • Broad cross-protection agianst H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes
    • Chen Y, Qin K, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JW, Peiris JS, Guan Y, Chen H and Xia N. (2009) Broad cross-protection agianst H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes. J. Infect. Dis. 199, 49-58.
    • (2009) J. Infect. Dis. , vol.199 , pp. 49-58
    • Chen, Y.1    Qin, K.2    Wu, W.L.3    Li, G.4    Zhang, J.5    Du, H.6    Ng, M.H.7    Shih, J.W.8    Peiris, J.S.9    Guan, Y.10    Chen, H.11    Xia, N.12
  • 15
    • 36749096389 scopus 로고    scopus 로고
    • Antibody induction by virosomal, MF59-adjuvanted, or conventional influenza vaccines in the elderly
    • De Bruijn I, Meyer I, Gerez L, Nauta J, Giezeman K, Palache B. (2007) Antibody induction by virosomal, MF59-adjuvanted, or conventional influenza vaccines in the elderly. Vaccine 26, 119.
    • (2007) Vaccine , vol.26 , pp. 119
    • De Bruijn, I.1    Meyer, I.2    Gerez, L.3    Nauta, J.4    Giezeman, K.5    Palache, B.6
  • 18
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 19
    • 0348078299 scopus 로고    scopus 로고
    • Mucosal antibody responses induced with a nasal virosome-based influenza vaccine
    • Durrer P, Gluck U, Spyr C, Lang AB, Zurbriggen R, Herzog C, Gluck R. (2003) Mucosal antibody responses induced with a nasal virosome-based influenza vaccine. Vaccine 21, 4328-4334.
    • (2003) Vaccine , vol.21 , pp. 4328-4334
    • Durrer, P.1    Gluck, U.2    Spyr, C.3    Lang, A.B.4    Zurbriggen, R.5    Herzog, C.6    Gluck, R.7
  • 20
    • 0034535166 scopus 로고    scopus 로고
    • Two influenza A virus-specific Fabs neutralize by inhibiting virus attachment to target cells, while neutralization by their IgGs is complex and occurs simultaneously through fusion inhibition and attachment inhibition
    • Edwards MJ, Dimmock NJ. (2000) Two influenza A virus-specific Fabs neutralize by inhibiting virus attachment to target cells, while neutralization by their IgGs is complex and occurs simultaneously through fusion inhibition and attachment inhibition. Virology 278, 423-435.
    • (2000) Virology , vol.278 , pp. 423-435
    • Edwards, M.J.1    Dimmock, N.J.2
  • 21
    • 0034983229 scopus 로고    scopus 로고
    • A haemagglutinin (HA1)-specific FAb neutralizes influenza A virus by inhibiting fusion activity
    • Edwards MJ, Dimmock NJ. (2001) A haemagglutinin (HA1)-specific FAb neutralizes influenza A virus by inhibiting fusion activity. J. Gen. Virol. 82, 387-1395.
    • (2001) J. Gen. Virol. , vol.82 , pp. 1387-1395
    • Edwards, M.J.1    Dimmock, N.J.2
  • 23
    • 33845534602 scopus 로고    scopus 로고
    • Structure and function of the influenza virus RNP
    • Kawaoka Y (Eds), Caister Academic Press, Norfolk, England
    • Elton D, Digard P, Tiley L, Ortin J. (2006) Structure and function of the influenza virus RNP. In Kawaoka Y (Eds) Influenza Virology, Current Topics. Caister Academic Press, Norfolk, England, pp. 1-36.
    • (2006) Influenza Virology, Current Topics , pp. 1-36
    • Elton, D.1    Digard, P.2    Tiley, L.3    Ortin, J.4
  • 26
    • 8644243888 scopus 로고    scopus 로고
    • Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes
    • Ferko B, Stasakova J, Romanova J, Kittel C, Sereinig S, Katinger H, Egorov A.. (2004) Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J. Virol. 78, 13037-13045.
    • (2004) J. Virol. , vol.78 , pp. 13037-13045
    • Ferko, B.1    Stasakova, J.2    Romanova, J.3    Kittel, C.4    Sereinig, S.5    Katinger, H.6    Egorov, A.7
  • 27
    • 33751249058 scopus 로고    scopus 로고
    • Live attenuated influenza virus expressing human interleukin-2 reveals increased immunogenic potential in young and aged hosts
    • Ferko B, Kittel C, Romanova J, Sereinig S, Katinger H, Egorov A. (2006) Live attenuated influenza virus expressing human interleukin-2 reveals increased immunogenic potential in young and aged hosts. J. Virol. 80,11621-11627.
    • (2006) J. Virol. , vol.80 , pp. 11621-11627
    • Ferko, B.1    Kittel, C.2    Romanova, J.3    Sereinig, S.4    Katinger, H.5    Egorov, A.6
  • 29
    • 33646011264 scopus 로고    scopus 로고
    • Differences in antibody responses of mice to intranasal or intraperitoneal immunization with influenza A virus and vaccination with subunit influenza vaccine
    • Fislová T, Sládková T, Gocník M, Mucha V, Varečková E, Kostolanský F. (2005) Differences in antibody responses of mice to intranasal or intraperitoneal immunization with influenza A virus and vaccination with subunit influenza vaccine. Acta Virol. 49, 243-250.
    • (2005) Acta Virol , vol.49 , pp. 243-250
    • Fislová, T.1    Sládková, T.2    Gocník, M.3    Mucha, V.4    Varečková, E.5    Kostolanský, F.6
  • 34
    • 0034977654 scopus 로고    scopus 로고
    • The role of the antibody response in influenza virus infection
    • Gerhard W. (2001) The role of the antibody response in influenza virus infection. Curr Top Microbiol. Immunol. 260, 171-190.
    • (2001) Curr Top Microbiol. Immunol. , vol.260 , pp. 171-190
    • Gerhard, W.1
  • 36
    • 33750071716 scopus 로고    scopus 로고
    • Emerging respiratory viruses challenges and vaccine strategies
    • Gillim-Ross L, Subbarao K. (2006) Emerging respiratory viruses challenges and vaccine strategies. Clin. Microbiol. Rev. 19, 614-636.
    • (2006) Clin. Microbiol. Rev. , vol.19 , pp. 614-636
    • Gillim-Ross, L.1    Subbarao, K.2
  • 37
    • 33847623088 scopus 로고    scopus 로고
    • Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection
    • Gocník M, Fislová T, Sládková T, Mucha V, Kostolanský F, Varečková E. (2007) Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection. J. Gen. Virol. 88, 951-955.
    • (2007) J. Gen. Virol. , vol.88 , pp. 951-955
    • Gocník, M.1    Fislová, T.2    Sládková, T.3    Mucha, V.4    Kostolanský, F.5    Varečková, E.6
  • 38
    • 45549102325 scopus 로고    scopus 로고
    • Antibodies induced by the HA2 glycopolypeptide of influenza virus haemagglutinin improve recovery from influenza A virus infection
    • Gocník M, Fislová T, Mucha V, Sládková T, Russ G, Kostolansky F, Varečková E. (2008) Antibodies induced by the HA2 glycopolypeptide of influenza virus haemagglutinin improve recovery from influenza A virus infection. J. Gen. Virol. 89, 958-967.
    • (2008) J. Gen. Virol. , vol.89 , pp. 958-967
    • Gocník, M.1    Fislová, T.2    Mucha, V.3    Sládková, T.4    Russ, G.5    Kostolansky, F.6    Varečková, E.7
  • 39
    • 0020626189 scopus 로고
    • Preparation of influenza virus subviral particles lacking the HA1 subunit of hemagglutinin unmasking of cross-reactive HA2 determinants
    • Graves PN, Schulman JL, Young JF, Palese P. (1983) Preparation of influenza virus subviral particles lacking the HA1 subunit of hemagglutinin unmasking of cross-reactive HA2 determinants. Virology 126, 106-116.
    • (1983) Virology , vol.126 , pp. 106-116
    • Graves, P.N.1    Schulman, J.L.2    Young, J.F.3    Palese, P.4
  • 40
    • 53649096656 scopus 로고    scopus 로고
    • Heterosubtypic immunity to influenza A virus where do we stand?
    • Grebe KM, Yewdell JW, Bennink JR. (2008) Heterosubtypic immunity to influenza A virus where do we stand? Microbes Infect. 10, 1024-1029.
    • (2008) Microbes Infect , vol.10 , pp. 1024-1029
    • Grebe, K.M.1    Yewdell, J.W.2    Bennink, J.R.3
  • 42
    • 0037135677 scopus 로고    scopus 로고
    • Eight-plasmid system for rapid generation of influenza virus vaccines
    • Hoffmann E, Krauss S, Perez D, Webby R, Webster RG. (2002) Eight-plasmid system for rapid generation of influenza virus vaccines. Vaccine 20, 3165-3170.
    • (2002) Vaccine , vol.20 , pp. 3165-3170
    • Hoffmann, E.1    Krauss, S.2    Perez, D.3    Webby, R.4    Webster, R.G.5
  • 44
    • 0024573756 scopus 로고
    • Purified influenza virus hemagglutinin and neuraminidase are equivalent in stimulation of antibody response but induce contrasting types of immunity to infection
    • Johansson BE, Bucher DJ, Kilbourne ED. (1989) Purified influenza virus hemagglutinin and neuraminidase are equivalent in stimulation of antibody response but induce contrasting types of immunity to infection. J. Virol. 63, 1239-1246.
    • (1989) J. Virol. , vol.63 , pp. 1239-1246
    • Johansson, B.E.1    Bucher, D.J.2    Kilbourne, E.D.3
  • 45
    • 0033538014 scopus 로고    scopus 로고
    • Immunization with influenza A hemagglutinin and neuraminidase produced in recombinant baculovirus results in a balanced and broadened immune response superior to conventional vaccine
    • Johansson BE. (1999) Immunization with influenza A hemagglutinin and neuraminidase produced in recombinant baculovirus results in a balanced and broadened immune response superior to conventional vaccine. Vaccine 17, 2073-2080.
    • (1999) Vaccine , vol.17 , pp. 2073-2080
    • Johansson, B.E.1
  • 47
    • 84899960172 scopus 로고    scopus 로고
    • Influenza vaccines current and future strategies
    • Kawaoka Y (Ed.), Caister Ac Press, Norfolk, England
    • Katz JM, Garg S, Sambhara S. (2006) Influenza vaccines current and future strategies. In Kawaoka Y (Ed.) Influenza Virology, Current Topics. Caister Ac Press, Norfolk, England, pp. 203-228.
    • (2006) Influenza Virology, Current Topics , pp. 203-228
    • Katz, J.M.1    Garg, S.2    Sambhara, S.3
  • 49
    • 0036998197 scopus 로고    scopus 로고
    • Natural influenza A virus infection of mice elicits strong antibody response to HA2 glycopolypeptide
    • Kostolanský F, Mucha V, Slováková R, Varečková E. (2002) Natural influenza A virus infection of mice elicits strong antibody response to HA2 glycopolypeptide. Acta Virol. 46, 229-236.
    • (2002) Acta Virol , vol.46 , pp. 229-236
    • Kostolanský, F.1    Mucha, V.2    Slováková, R.3    Varečková, E.4
  • 50
    • 46349102241 scopus 로고    scopus 로고
    • Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus
    • Lalor PA, Webby RJ, Morrow J, Rusalov D, Kaslow DC, Rolland A, Smith LR. (2008) Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus. J. Infect. Dis. 197,1643-1652.
    • (2008) J. Infect. Dis. , vol.197 , pp. 1643-1652
    • Lalor, P.A.1    Webby, R.J.2    Morrow, J.3    Rusalov, D.4    Kaslow, D.C.5    Rolland, A.6    Smith, L.R.7
  • 51
    • 32944460784 scopus 로고    scopus 로고
    • Avian Flu to Human Influenza
    • Lewis DB. (2006) Avian Flu to Human Influenza. Annu. Rev. Med. 57, 139-154.
    • (2006) Annu. Rev. Med. , vol.57 , pp. 139-154
    • Lewis, D.B.1
  • 52
    • 47749151914 scopus 로고    scopus 로고
    • Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1
    • Lim AP, Wong SK, Chan AH, Chan CE, Ooi EE, Hanson BJ. (2008) Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1. Virol. J. 5, 80.
    • (2008) Virol. J. , vol.5 , pp. 80
    • Lim, A.P.1    Wong, S.K.2    Chan, A.H.3    Chan, C.E.4    Ooi, E.E.5    Hanson, B.J.6
  • 53
    • 0031406072 scopus 로고    scopus 로고
    • Prevention and treatment of lethal influenza A virus bronchopneumonia in mice by monoclonal antibody against hemagglutinin stem region
    • Lipatov AS, Gitelman AK, Smirnov YA. (1997) Prevention and treatment of lethal influenza A virus bronchopneumonia in mice by monoclonal antibody against hemagglutinin stem region. Acta Virol. 41, 337-340.
    • (1997) Acta Virol , vol.41 , pp. 337-340
    • Lipatov, A.S.1    Gitelman, A.K.2    Smirnov, Y.A.3
  • 54
  • 56
    • 34447622953 scopus 로고    scopus 로고
    • The value of a database in surveillance and vaccine selection
    • Osterhaus ADME, Cox N, Hampson AW. Amsterdam (Eds), Elsevier Science
    • Macken C, Lu H, Goodman J, Boykin L. (2001) The value of a database in surveillance and vaccine selection. In Osterhaus ADME, Cox N, Hampson AW. Amsterdam (Eds) Options for the Control of Influenza IV. Elsevier Science, pp. 103-106.
    • (2001) Options for the Control of Influenza IV , pp. 103-106
    • Macken, C.1    Lu, H.2    Goodman, J.3    Boykin, L.4
  • 57
    • 0026006258 scopus 로고
    • Nuclear transport of influenza virus ribonucleoproteins the viral matrix protein (M1) promotes export and inhibits import
    • Martin K, Helenius A. (1991) Nuclear transport of influenza virus ribonucleoproteins the viral matrix protein (M1) promotes export and inhibits import. Cell 67, 117-130. doi:10.1016/0092-8674(91)90576-K.
    • (1991) Cell , vol.67 , pp. 117-130
    • Martin, K.1    Helenius, A.2
  • 58
    • 0027378503 scopus 로고
    • Induction of CD8+ cytotoxic T cells by immunization with killed influenza virus and effect of cholera toxin B subunit
    • Mbawuike IN, Wyde PR. (1993) Induction of CD8+ cytotoxic T cells by immunization with killed influenza virus and effect of cholera toxin B subunit. Vaccine 11, 1205-1213.
    • (1993) Vaccine , vol.11 , pp. 1205-1213
    • Mbawuike, I.N.1    Wyde, P.R.2
  • 59
    • 68349085753 scopus 로고    scopus 로고
    • Novel Swine-origin influenza A virus in humans another pandemic knocking at the door
    • Michaelis M, Doerr HW, Cinatl J Jr. (2009) Novel Swine-origin influenza A virus in humans another pandemic knocking at the door. Med. Microbiol. Immunol. 198, 175-183.
    • (2009) Med. Microbiol. Immunol. , vol.198 , pp. 175-183
    • Michaelis, M.1    Doerr, H.W.2    Cinatl Jr., J.3
  • 60
    • 0033674545 scopus 로고    scopus 로고
    • Transcription and replication of the influenza A virus genome
    • Mikulášová A, Varečková E, Fodor E. (2000) Transcription and replication of the influenza A virus genome. Acta Virol. 44, 273-282.
    • (2000) Acta Virol , vol.44 , pp. 273-282
    • Mikulášová, A.1    Varečková, E.2    Fodor, E.3
  • 61
    • 0037435883 scopus 로고    scopus 로고
    • Induction of heterosubtypic imunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins
    • Mitchell JA, Green TD, Bright RA, Ross TM. (2003) Induction of heterosubtypic imunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins. Vaccine 21, 902-914.
    • (2003) Vaccine , vol.21 , pp. 902-914
    • Mitchell, J.A.1    Green, T.D.2    Bright, R.A.3    Ross, T.M.4
  • 62
    • 0024529561 scopus 로고
    • The systemic and mucosal immune response of humans to influenza A virus
    • Murphy BR, Clements ML. (1989) The systemic and mucosal immune response of humans to influenza A virus. Curr. Top. Microb. Immunol. 146, 07-116.
    • (1989) Curr. Top. Microb. Immunol. , vol.146 , pp. 107-116
    • Murphy, B.R.1    Clements, M.L.2
  • 63
    • 18244377785 scopus 로고    scopus 로고
    • Immunity to viruses
    • Roitt I, Brostoff J, Male D (Eds), 5th ed. Mosby, London
    • Nash T. (1998) Immunity to viruses. In Roitt I, Brostoff J, Male D (Eds) Immunology. 5th ed., Mosby, London, pp. 221-228.
    • (1998) Immunology , pp. 221-228
    • Nash, T.1
  • 64
    • 0032874490 scopus 로고    scopus 로고
    • A universal influenza a vaccine based on the extracellular domain of the M2 protein
    • Neirynck S, Deroo T, Saelens X, Vanlandschoot P, Jou WM, Fiers W. (1999) A universal influenza a vaccine based on the extracellular domain of the M2 protein. Nat. Med. 5, 1119-1120.
    • (1999) Nat. Med. , vol.5 , pp. 1119-1120
    • Neirynck, S.1    Deroo, T.2    Saelens, X.3    Vanlandschoot, P.4    Jou, W.M.5    Fiers, W.6
  • 66
    • 0036148383 scopus 로고    scopus 로고
    • Generation of influenza A virus from cloned cDNAs-historical perspective and outlook for the new millenium
    • Neumann G, Kawaoka Y. (2002) Generation of influenza A virus from cloned cDNAs-historical perspective and outlook for the new millenium. Rev. Med. Virol. 12, 13-30.;.
    • (2002) Rev. Med. Virol. , vol.12 , pp. 13-30
    • Neumann, G.1    Kawaoka, Y.2
  • 67
    • 0026175939 scopus 로고
    • Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses
    • Nobusawa E, Aoyama T, Kato H, Suzuki Y, Tateno Y, Nakajima K. (1991) Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influeChen J, Whartonnza A viruses. Virology 182, 475-485.
    • (1991) Virology , vol.182 , pp. 475-485
    • Nobusawa, E.1    Aoyama, T.2    Kato, H.3    Suzuki, Y.4    Tateno, Y.5    Nakajima, K.6
  • 68
    • 0027471177 scopus 로고
    • A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
    • Okuno Y, Isegawa Y, Sasao F, Ueda S. (1993) A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains. J. Virol. 67, 2552-2558.
    • (1993) J. Virol. , vol.67 , pp. 2552-2558
    • Okuno, Y.1    Isegawa, Y.2    Sasao, F.3    Ueda, S.4
  • 69
    • 31344450870 scopus 로고    scopus 로고
    • Making better influenza virus vaccines?
    • Palese P. (2006) Making better influenza virus vaccines? Emerg. Infect. Dis. 12, 61-65.
    • (2006) Emerg. Infect. Dis. , vol.12 , pp. 61-65
    • Palese, P.1
  • 70
    • 0036308877 scopus 로고    scopus 로고
    • Influenza vaccines present and future
    • Palese P, García-Sastre A. (2002) Influenza vaccines present and future. J. Clin. Invest. 110, 9-13.
    • (2002) J. Clin. Invest. , vol.110 , pp. 9-13
    • Palese, P.1    García-Sastre, A.2
  • 71
    • 34447299235 scopus 로고    scopus 로고
    • Orthomyxoviridae The viruses and their replication
    • Knipe DM, Howley PM (Eds),5th ed. Lippincott Wiliams and Wilkins
    • Palese P, Shaw ML. (2007) Orthomyxoviridae The viruses and their replication In Knipe DM, Howley PM (Eds) Fields Virology. 5th ed., Lippincott Wiliams and Wilkins, pp. 1647-1689.
    • (2007) Fields Virology , pp. 1647-1689
    • Palese, P.1    Shaw, M.L.2
  • 72
    • 0028965256 scopus 로고
    • Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice
    • Palladino G, Mozdzanowska K, Washko G, Gerhard W. (1995) Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J. Virol. 69, 2075-2081.
    • (1995) J. Virol. , vol.69 , pp. 2075-2081
    • Palladino, G.1    Mozdzanowska, K.2    Washko, G.3    Gerhard, W.4
  • 73
    • 62749124125 scopus 로고    scopus 로고
    • Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection
    • Prabhu N, Prabakaran M, Ho HT, Velumani S, Qiang J, Goutama M, Kwang J. (2009) Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection. J. Virol. 83, 2553-2562.
    • (2009) J. Virol. , vol.83 , pp. 2553-2562
    • Prabhu, N.1    Prabakaran, M.2    Ho, H.T.3    Velumani, S.4    Qiang, J.5    Goutama, M.6    Kwang, J.7
  • 74
    • 27944456097 scopus 로고    scopus 로고
    • Influenza viruslike particles comprised of the HA NA and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice
    • Pushko P, Tumpey TM, Bu F, Knell J, Robinson R, Smith G. (2005) Influenza viruslike particles comprised of the HA, NA and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice. Vaccine 23, 5751-5759.
    • (2005) Vaccine , vol.23 , pp. 5751-5759
    • Pushko, P.1    Tumpey, T.M.2    Bu, F.3    Knell, J.4    Robinson, R.5    Smith, G.6
  • 75
    • 0025924358 scopus 로고
    • NS2 protein of influenza virus is found in purified virus and phosforylated in infected cells
    • Richardson JC, Akkina RK. (1991) NS2 protein of influenza virus is found in purified virus and phosforylated in infected cells. Arch. Virol. 116, 69-80.
    • (1991) Arch. Virol. , vol.116 , pp. 69-80
    • Richardson, J.C.1    Akkina, R.K.2
  • 77
    • 0001909321 scopus 로고    scopus 로고
    • Structure of Influenza A, B and C Viruses
    • In Nicholson KG, Webster RG, Hay AJ (Eds), Blackwell Science, GB
    • Ruigrok RWH. (1998) Structure of Influenza A, B and C Viruses. In Nicholson KG, Webster RG, Hay AJ (Eds) Textbook of Influenza. Blackwell cience, GB, 29-48.
    • (1998) Textbook of Influenza , pp. 29-48
    • Ruigrok, R.W.H.1
  • 78
    • 0023413967 scopus 로고
    • Monoclonal antibodies to glycopeptides HA1 and HA2 of influenza virus hemagglutinin
    • Russ G, Poláková K, Kostolanský F, Styk B, Vančiková M. (1987) Monoclonal antibodies to glycopeptides HA1 and HA2 of influenza virus hemagglutinin. Acta Virol. 31, 374-386.
    • (1987) Acta Virol , vol.31 , pp. 374-386
    • Russ, G.1    Poláková, K.2    Kostolanský, F.3    Styk, B.4    Vančiková, M.5
  • 79
    • 0023553301 scopus 로고
    • Isolation of cross-reactive, subtype-specific monoclonal antibodies against influenza virus HA1 and HA2 hemagglutinin subunits
    • Sanchez-Fauquier A, Villanueva N, Melero JA. (1987) Isolation of cross-reactive, subtype-specific monoclonal antibodies against influenza virus HA1 and HA2 hemagglutinin subunits. Arch. Virol. 97, 251-265.
    • (1987) Arch. Virol. , vol.97 , pp. 251-265
    • Sanchez-Fauquier, A.1    Villanueva, N.2    Melero, J.A.3
  • 80
    • 39549118698 scopus 로고    scopus 로고
    • Clinical review Update of avian influenza A infections in humans
    • Sandrock Ch, Kelly T. (2007) Clinical review Update of avian influenza A infections in humans. Critical Care 11, 1-9 d.
    • (2007) Critical Care , vol.11 , pp. 1-9
    • Sandrock, C.h.1    Kelly, T.2
  • 81
    • 0036147470 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha exerts powerful anti-influenza virus effects in lung epithelial cells
    • Seo SH, Webster RG. (2002) Tumor necrosis factor alpha exerts powerful anti-influenza virus effects in lung epithelial cells. J. Virol. 76, 1071-1076.
    • (2002) J. Virol. , vol.76 , pp. 1071-1076
    • Seo, S.H.1    Webster, R.G.2
  • 84
    • 0033783032 scopus 로고    scopus 로고
    • Receptor binding and membrane fusion in virus entry The influenza hemagglutinin
    • Skehel JJ, Wiley DC. (2000) Receptor binding and membrane fusion in virus entry The influenza hemagglutinin. Annu. Rev. Biochem. 69, 531-569.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 531-569
    • Skehel, J.J.1    Wiley, D.C.2
  • 85
    • 0033857323 scopus 로고    scopus 로고
    • Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem
    • Smirnov YA, Lipatov SA, Gitelman AK, Claas ECJ, Osterhaus ADME. (2000) Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem. Arch. Virol. 145, 1733-1741.
    • (2000) Arch. Virol. , vol.145 , pp. 1733-1741
    • Smirnov, Y.A.1    Lipatov, S.A.2    Gitelman, A.K.3    Claas, E.C.J.4    Osterhaus, Adme.5
  • 87
    • 0037424108 scopus 로고    scopus 로고
    • Comparison of the reactogenicity and immunogenicity of a split and a subunit-adjuvanted influenza vaccine in elderly subjects
    • Squarcione S, Sgricia S, Biasio LR, Perinetti E. (2003) Comparison of the reactogenicity and immunogenicity of a split and a subunit-adjuvanted influenza vaccine in elderly subjects. Vaccine 21, 1268-1274.
    • (2003) Vaccine , vol.21 , pp. 1268-1274
    • Squarcione, S.1    Sgricia, S.2    Biasio, L.R.3    Perinetti, E.4
  • 89
    • 65549111747 scopus 로고    scopus 로고
    • Broadly cross-reactive monoclonal antibodies against HA2 glycopeptide of Influenza A virus hemagglutinin of H3 subtype reduce replication of influenza A viruses of human and avian origin
    • doi:10.4149/av_2009_01 _15
    • Stropkovská A, Mucha V, Fislová T, Gocník M, Kostolanský F, Varečková E. (2009) Broadly cross-reactive monoclonal antibodies against HA2 glycopeptide of Influenza A virus hemagglutinin of H3 subtype reduce replication of influenza A viruses of human and avian origin. Acta Virol. 53, 15-20. doi:10.4149/av_2009_01 _15.
    • (2009) Acta Virol , vol.53 , pp. 15-20
    • Stropkovská, A.1    Mucha, V.2    Fislová, T.3    Gocník, M.4    Kostolanský, F.5    Varečková, E.6
  • 90
    • 0018333851 scopus 로고
    • Antigenic glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin IV. Immunogenic properties of separated haemagglutinin glycopolypeptides
    • Styk B, Russ G, Poláková K. (1979) Antigenic glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin. IV. Immunogenic properties of separated haemagglutinin glycopolypeptides. Acta Virol. 23, 9-20.
    • (1979) Acta Virol , vol.23 , pp. 9-20
    • Styk, B.1    Russ, G.2    Poláková, K.3
  • 92
    • 0038120851 scopus 로고    scopus 로고
    • Intranasal immunisation with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza a virus infection in mice
    • Takada A, Matsushita S, Ninomiya A, Kawaoka Y, Kida H. (2003) Intranasal immunisation with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza a virus infection in mice. Vaccine 21, 3212-3218.
    • (2003) Vaccine , vol.21 , pp. 3212-3218
    • Takada, A.1    Matsushita, S.2    Ninomiya, A.3    Kawaoka, Y.4    Kida, H.5
  • 94
    • 0023767597 scopus 로고
    • Protection against influenza virus infection by vaccine inoculated intranassaly with cholera toxin B subunit
    • Tamura S, Samegai Y, Kurata H, Nagamine T, Aizawa C, Kurata T. (1988) Protection against influenza virus infection by vaccine inoculated intranassaly with cholera toxin B subunit. Vaccine 6, 409-413.
    • (1988) Vaccine , vol.6 , pp. 409-413
    • Tamura, S.1    Samegai, Y.2    Kurata, H.3    Nagamine, T.4    Aizawa, C.5    Kurata, T.6
  • 95
  • 96
    • 26844454091 scopus 로고    scopus 로고
    • Mechanisms of Broad Cross-Protection Provided by Influenza Virus Infection and Their Application to Vaccines
    • Tamura S, Tanimoto T, Kurata T. (2005) Mechanisms of Broad Cross-Protection Provided by Influenza Virus Infection and Their Application to Vaccines. Jpn. J. Infect. Dis. 58, 1196-1198.
    • (2005) Jpn. J. Infect. Dis. , vol.58 , pp. 1196-1198
    • Tamura, S.1    Tanimoto, T.2    Kurata, T.3
  • 97
    • 0022647790 scopus 로고
    • Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo
    • Taylor PM, Askonas BA. (1986) Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. Immunology 58, 417-420.
    • (1986) Immunology , vol.58 , pp. 417-420
    • Taylor, P.M.1    Askonas, B.A.2
  • 99
    • 1842292725 scopus 로고    scopus 로고
    • Evaluation of monoclonal antibodies for subtyping of currently circulating human type A influenza viruses
    • Tkáčová M, Varečková E, Baker IC, Love JM, Ziegler T. (1997) Evaluation of monoclonal antibodies for subtyping of currently circulating human type A influenza viruses. J. Clin. Microbiol. 35, 1196-1198.
    • (1997) J. Clin. Microbiol. , vol.35 , pp. 1196-1198
    • Tkáčová, M.1    Varečková, E.2    Baker, I.C.3    Love, J.M.4    Ziegler, T.5
  • 101
    • 0037095578 scopus 로고    scopus 로고
    • Influenza DNA vaccines
    • Ulmer JB. (2002) Influenza DNA vaccines. Vaccine 20 (Suppl. 2), 74-76.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 2 , pp. 74-76
    • Ulmer, J.B.1
  • 103
    • 15644375941 scopus 로고    scopus 로고
    • An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus
    • Vanlandschoot P, Beirnaert E, Barrère B, Calder L, Millar B, Wharton S, Jou WM, Fiers W. (1998) An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus. J. Gen. Virol. 79, 1781-1791.
    • (1998) J. Gen. Virol. , vol.79 , pp. 1781-1791
    • Vanlandschoot, P.1    Beirnaert, E.2    Barrère, B.3    Calder, L.4    Millar, B.5    Wharton, S.6    Jou, W.M.7    Fiers, W.8
  • 104
    • 0036263201 scopus 로고    scopus 로고
    • Evaluation of subtype specificity of monoclonal antibodies raised against H1 and H3 subtypes of human influenza A virus hemagglutinins
    • Varečková E, Cox N, Klimov A. (2002) Evaluation of subtype specificity of monoclonal antibodies raised against H1 and H3 subtypes of human influenza A virus hemagglutinins. J. Clin. Microbiol. 40, 2220-2223.
    • (2002) J. Clin. Microbiol. , vol.40 , pp. 2220-2223
    • Varečková, E.1    Cox, N.2    Klimov, A.3
  • 105
    • 17144464993 scopus 로고    scopus 로고
    • Inhibition of fusion activity of influenza A haemagglutinin mediated by HA2-specific monoclonal antibodies
    • Varečková E, Mucha V, Wharton SA, Kostolanský F. (2003a) Inhibition of fusion activity of influenza A haemagglutinin mediated by HA2-specific monoclonal antibodies. Arch. Virol. 148, 469-486.
    • (2003) Arch. Virol. , vol.148 , pp. 469-486
    • Varečková, E.1    Mucha, V.2    Wharton, S.A.3    Kostolanský, F.4
  • 106
    • 0442294070 scopus 로고    scopus 로고
    • A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus
    • Varečková E, Wharton SA, Mucha V, Gocník M, Kostolanský F. (2003b) A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus. Acta Virol. 47, 229-236.
    • (2003) Acta Virol , vol.47 , pp. 229-236
    • Varečková, E.1    Wharton, S.A.2    Mucha, V.3    Gocník, M.4    Kostolanský, F.5
  • 107
    • 38949184513 scopus 로고    scopus 로고
    • HA2-specific monoclonal antibodies as tools for differential recognition of influenza A virus antigenic subtypes
    • Varečková E, Mucha V, Kostolanský F, Gubareva LV, Klimov A. (2008) HA2-specific monoclonal antibodies as tools for differential recognition of influenza A virus antigenic subtypes. Virus Res. 132, 181-186.
    • (2008) Virus Res , vol.132 , pp. 181-186
    • Varečková, E.1    Mucha, V.2    Kostolanský, F.3    Gubareva, L.V.4    Klimov, A.5
  • 108
    • 62049084901 scopus 로고    scopus 로고
    • Universal epitopes of influenza virus hemagglutinins?
    • Wang TT and Palese P. (2009) Universal epitopes of influenza virus hemagglutinins? Nat. Struct. Mol. Biol. 16, 233-234.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 233-234
    • Wang, T.T.1    Palese, P.2
  • 109
    • 0036139062 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of replicationincompetent influenza virus-like particles
    • Watanabe T, Watanabe S, Neumann G, Kida H, Kawaoka Y. (2002a) Immunogenicity and protective efficacy of replicationincompetent influenza virus-like particles. J. Virol. 76, 767-773.
    • (2002) J. Virol. , vol.76 , pp. 767-773
    • Watanabe, T.1    Watanabe, S.2    Neumann, G.3    Kida, H.4    Kawaoka, Y.5
  • 110
    • 0036434127 scopus 로고    scopus 로고
    • Influenza A virus with defective M2 ion channel activity as a live vaccine
    • Watanabe T, Watanabe S, Kida H, Kawaoka Y. (2002b) Influenza A virus with defective M2 ion channel activity as a live vaccine. Virology 299, 266-270.
    • (2002) Virology , vol.299 , pp. 266-270
    • Watanabe, T.1    Watanabe, S.2    Kida, H.3    Kawaoka, Y.4
  • 111
    • 0023915219 scopus 로고
    • Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
    • Weis W, Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC. (1988) Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature 333, 426-431.
    • (1988) Nature , vol.333 , pp. 426-431
    • Weis, W.1    Brown, J.H.2    Cusack, S.3    Paulson, J.C.4    Skehel, J.J.5    Wiley, D.C.6
  • 112
    • 4043181266 scopus 로고    scopus 로고
    • Protection of weaned pigs by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of H3N2 swine influenza virus
    • Wesley RD, Tang M, Lager KM. (2004) Protection of weaned pigs by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of H3N2 swine influenza virus. Vaccine 22, 3427-3434.
    • (2004) Vaccine , vol.22 , pp. 3427-3434
    • Wesley, R.D.1    Tang, M.2    Lager, K.M.3
  • 113
    • 0002300306 scopus 로고    scopus 로고
    • Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin
    • Chiu W, Burnett RM, Garcea RL (Eds), Oxford University Press NY
    • White JM, Hoffman LR, Arevalo JH, Wilson IA. (1997) Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin. In Chiu W, Burnett RM, Garcea RL (Eds) Structural Biology of Viruses. Oxford University Press NY, pp. 80-104.
    • (1997) Structural Biology of Viruses , pp. 80-104
    • White, J.M.1    Hoffman, L.R.2    Arevalo, J.H.3    Wilson, I.A.4
  • 114
    • 0019432165 scopus 로고
    • Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
    • Wiley DC, Wilson IA, Skehel JJ. (1981) Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289, 373-378.
    • (1981) Nature , vol.289 , pp. 373-378
    • Wiley, D.C.1    Wilson, I.A.2    Skehel, J.J.3
  • 115
    • 0023082135 scopus 로고
    • The structure and function of the hemagglutinin membrane glycoprotein of influenza virus
    • Wiley DC, Skehel. (1987) The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu. Rev. Biochem. 56, 365-394.
    • (1987) Annu. Rev. Biochem. , vol.56 , pp. 365-394
    • Wiley, D.C.1    Skehel2
  • 116
    • 0035885006 scopus 로고    scopus 로고
    • Antigenspecific CD8(+) T cells persist in the upper respiratory tract following influenza virus infection
    • Wiley JA, Hogan RJ, Woodland DL, Harmsen AG. (2001) Antigenspecific CD8(+) T cells persist in the upper respiratory tract following influenza virus infection. J. Immunol. 167, 3293-3299.
    • (2001) J. Immunol. , vol.167 , pp. 3293-3299
    • Wiley, J.A.1    Hogan, R.J.2    Woodland, D.L.3    Harmsen, A.G.4
  • 118
    • 69249091829 scopus 로고    scopus 로고
    • The 2009 influenza pandemic begins Influenza Other Respi
    • Wood JM. (2009) The 2009 influenza pandemic begins. Influenza Other Respi. Viruses 3, 197-198.
    • (2009) Viruses , vol.3 , pp. 197-198
    • Wood, J.M.1
  • 119
    • 34547776050 scopus 로고    scopus 로고
    • Ortomyxoviruses
    • Knipe DM, Howley PM (Eds), Fields Virology. 5th ed
    • Wright PF, Neumann G, Kawaoka Y. (2007) Ortomyxoviruses. In Knipe DM, Howley PM (Eds) Fields Virology. 5th ed., Lippincott Wiliams and Wilkins, pp.1693-1741.
    • (2007) Lippincott Wiliams and Wilkins , pp. 1693-1741
    • Wright, P.F.1    Neumann, G.2    Kawaoka, Y.3
  • 120
    • 70349301940 scopus 로고    scopus 로고
    • Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine
    • Wu F, Yuan XY, Huang WS, Chen YH. (2008) Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine. Vaccine 27, 6095-6101.
    • (2008) Vaccine , vol.27 , pp. 6095-6101
    • Wu, F.1    Yuan, X.Y.2    Huang, W.S.3    Chen, Y.H.4
  • 121
    • 0011893036 scopus 로고
    • Influenza A virus nucleoprotein is a major target antigen for crossreactive anti-influenza A virus cytotoxic T lymphocytes
    • Yewdell JW, Bennink JR, Smith GL, Moss B. (1985) Influenza A virus nucleoprotein is a major target antigen for crossreactive anti-influenza A virus cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 82, 1785-1789.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 1785-1789
    • Yewdell, J.W.1    Bennink, J.R.2    Smith, G.L.3    Moss, B.4
  • 122
    • 63449125762 scopus 로고    scopus 로고
    • Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses
    • Yoshida R, Igarashi M, Ozaki H, Kishida N, Tomabechi D, Kida H, Ito K, Takada A. (2009):Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. PLoS Pathog. 5, e1000350.
    • (2009) PLoS Pathog , vol.5
    • Yoshida, R.1    Igarashi, M.2    Ozaki, H.3    Kishida, N.4    Tomabechi, D.5    Kida, H.6    Ito, K.7    Takada, A.8
  • 123
    • 77951059450 scopus 로고    scopus 로고
    • Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1
    • Zamarin D, Garcia-Sastre A, Xiao X, Wang R, Palese P. (2005) Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1.PLoS Pathog. 1, e4.
    • (2005) PLoS Pathog , vol.1
    • Zamarin, D.1    Garcia-Sastre, A.2    Xiao, X.3    Wang, R.4    Palese, P.5


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