Cardiac isoform of alpha 2 macroglobulin: A marker of cardiac involvement in pediatric HIV and AIDS

Pediatric Cardiology

Volumn 31, Issue 2, 2010, Pages 203-207

  Meenakshisundaram, Ramachandran ^a,d   Sweni, Shah ^b   Thirumalaikolundusubramanian, Ponniah ^c  

^a MADRAS MEDICAL COLLEGE   (India)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c Chennai Medical College Hospital   (India)

^d NONE   (India)

Author keywords

Alpha 2 macroglobulin; CA2M; Cardiac biomarker; Heart; HIV AIDS; Pediatrics

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CARDIOMYOPATHY; CD4 LYMPHOCYTE COUNT; CHILD; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HEART DISEASE; HEART LEFT VENTRICLE FAILURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PERICARDIAL EFFUSION; PRESCHOOL CHILD; PULMONARY HYPERTENSION; SEX; BLOOD; CASE CONTROL STUDY; EVALUATION; METABOLISM; VIROLOGY;

ALPHA-MACROGLOBULINS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; FEMALE; HEART DISEASES; HIV INFECTIONS; HUMANS; MALE;

EID: 77952314589     PISSN: 01720643     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00246-009-9584-1     Document Type: Article

References (32)

1. Lipshultz SE, Chanock S, Sanders SP, Colan SD, Perez-Atayde A, McIntosh K (1989) Cardiovascular manifestations of human immunodeficiency virus infection in infants and children. Am J Cardiol 63:1489-1497 (Pubitemid 19153801)
2. Luginbuhl LM, Orav EJ, McIntosh K, Lipshultz SE (1993) Cardiac morbidity and related mortality in children with HIV infection. JAMA 269(22):2869-2875
3. Barbaro G, Di Lorenzo G, Grisorio B, Barbarini G (1998) Cardiac involvement in the acquired immunodeficiency syndrome: a multicenter clinical-pathological study. Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS Investigators. AIDS Res Hum Retrovir 14:1071-1077
4. Starc TJ, Lipshultz SE, Easley KA, Kaplan S, Bricker JT, Colan SD et al (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: the prospective P2C2 HIV study. J Pediatr 141:327-334
5. Hubbard J (2003) Common biochemical markers for diagnosing heart disease. Nurs Times 99:24-25
6. Rajappa M, Sharma A (2005) Biomarkers of cardiac injury: an update. Angiology 56:677-691
7. Okubo H, Miyanaga O, Nagano M, Ishibashi H, Kudo J, Ikuta T et al (1981) Purification and immunological determination of alpha 2-macroglobulin in serum from injured rats. Biochim Biophys Acta 668:257-267
8. Ramasamy S, Omnath R, Rathinavel A, Kannan P, Dhandapany PS, Annapoorani P et al (2006) Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients. AIDS 20(15):1979-1981
9. Rajamanickam C, Sakthivel S, Babu GJ, Lottspeich F, Kadenbach B (2001) Cardiac isoform of alpha-2 macroglobin, a novel serum protein, may induce cardiac hypertrophy in rats. Basic Res Cardiol 96:23-33
10. Rajamanickam C, Sakthivel S, Kurian Joseph P, Athimoolam Janarthanan R (1998) A novel serum protein of molecular weight 182 kDa: a molecular marker for an early detection of increased left ventricular mass in patients with cardiac hypertrophy. J Cardiovasc Risk 5:335-338
11. Annapoorani P, Dhandapany PS, Sadayappan S, Ramasamy S, Rathinavel A, Selvam GS (2006) Cardiac isoform of alpha-2 macroglobulin-a new biomarker for myocardial infarcted diabetic patients. Atherosclerosis 186:173-176
12. National AIDS Control Organization, India (2006) Guidelines for HIV care and treatment in infants and children. Ministry of Health & Family Welfare, Government of India, New Delhi
13. Pezzullo J (2009) Interactive statistical calculation pages; Statpages. org. Available at: http://www.statpages.org/#comparisons. Accessed 29 Aug 2009
14. Lipshultz SE, Easley KA, Orav EJ, Kaplan S, Starc TJ, Bricker JT et al (2000) Cardiac dysfunction and mortality in HIV-infected children: the prospective P2C2 HIV multicenter study. Pediatric pulmonary and cardiac complications of vertically transmitted HIV infection (P2C2 HIV) study group. Circulation 102:1542-1548
15. Harmon WG, Dadlani GH, Fisher SD, Lipshultz SE (2002) Myocardial and pericardial disease in HIV. Curr Treat Options Cardiovasc Med 4:497-509
16. Currie PF, Goldman JH, Caforio AL, Jacob AJ, Baig MK, Brettle RP et al (1998) Cardiac autoimmunity in HIV related heart muscle disease. Heart 79:599-604
17. Lewis W, Dorn GW 2nd (1993) Cardiac structure and function in HIV-infected children. N Engl J Med 328:513-514
18. Joshi VV, Gadol C, Connor E, Oleske JM, Mendelson J, Marin- Garcia J (1988) Dilated cardiomyopathy in children with acquired immunodeficiency syndrome: a pathologic study of five cases. Hum Pathol 19:69-73
19. Shah I, Prabhu SS, Shashikiran HS (2005) Cardiac dysfunction in HIV infected children: A pilot study. Indian Pediatr 42:146-149VS
20. Stewart JM, Kaul A, Gromisch DS, Reyes E, Woolf PK, Gowitz MH (1989) Symptomatic cardiac dysfunction in children with human immunodeficiency virus infection. Am Heart J 117: 140-144
21. Francis CK (1990) Cardiac involvement in AIDS. Curr Probl Cardiol 15:569-639
22. Gentry P (1999) Acute phase proteins. In: Loeb WF, Quimby FW (eds) The clinical chemistry of laboratory animals, 2nd edn. Taylor and Francis, Philadelphia, pp 336-398
23. Debanne MT, Bell R, Dolovich J (1976) Characteristics of the macrophage uptake of proteinase-alpha-macroglobulin complexes. Biochim Biophys Acta 428:466-475
24. Barrett AJ, Brown MA, Sayers CA (1979) The electrophoretically 'slow' and 'fast' forms of the alpha 2-macroglobulin molecule. Biochem J 181:401-418
25. Ahmad J, Singh M, Saleemuddin M (2001) A study of plasma alpha-2-macroglobulin levels in type 2 diabetic subjects with microalbuminuria. J Assoc Physicians India 49:1062-1065
26. Burnett D, Stockley RA (1981) Serum and sputum alpha 2 macroglobulin in patients with chronic obstructive airways disease. Thorax 36:512-516
27. Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY (2004) Reference distributions for alpha2-macroglobulin: a practical, simple and clinically relevant approach in a large cohort. J Clin Lab Anal 18:139-147 (Pubitemid 38468998)
28. Makis ACHE, Mavridis A, Bourantas KL (2001) Alpha-2 macroglobulin and interleukin-6 levels in steady-state sickle cell disease patients. Acta Haematol 104:164-168
29. Cannon JG, Angel JB, Ball RW, Abad LW, Fagioli L, Komaroff AL (1999) Acute phase responses and cytokine secretion in chronic fatigue syndrome. J Clin Immunol 19:414-421
30. Banks RE, Evans SW, Alexander D, Van Leuven F, Whicher JT, McMahon MJ (1991) Alpha 2 macroglobulin state in acute pancreatitis. Raised values of alpha 2 macroglobulin-protease complexes in severe and mild attacks. Gut 32:430-434
31. Doherty NS, Littman BH, Reilly K, Swindell AC, Buss JM, Anderson NL (1998) Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis. Electrophoresis 19:355-363
32. van Gool J, van Vugt H, de Bont E (1990) Alpha 2-macroglobulin and fibrinogen modulate inflammatory edema in man. Inflammation 14:275-283