Altered regional cerebral glucose metabolism in internet game overusers: A 18F-fluorodeoxyglucose positron emission tomography study

CNS Spectrums

Volumn 15, Issue 3, 2010, Pages 159-166

  Park, Hyun Soo ^a   Kim, Sang Hee ^b   Bang, Seong Ae ^a   Yoon, Eun Jin ^a   Cho, Sang Soo ^a   Kim, Sang Eun ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; DIAGNOSTIC AGENT; GLUCOSE; RADIOPHARMACEUTICAL AGENT;

ADULT; ARTICLE; BRAIN METABOLISM; BRAIN REGION; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; GLUCOSE METABOLISM; HUMAN; IMPULSIVENESS; INSULA; INTERNET ADDICTION; MALE; NEUROBIOLOGY; OCCIPITAL CORTEX; ORBITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RIGHT HANDEDNESS; ADDICTION; BRAIN LEVEL; IMAGE PROCESSING; INTERNET; METABOLISM; NEOSTRIATUM; PHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGICAL ASPECT; RECREATION; SCINTISCANNING;

ADULT; BEHAVIOR, ADDICTIVE; BRAIN CHEMISTRY; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMPULSIVE BEHAVIOR; INTERNET; MALE; NEOSTRIATUM; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; RADIOPHARMACEUTICALS; VIDEO GAMES; YOUNG ADULT;

EID: 77952310277     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1092852900027437     Document Type: Article

References (41)

1. Block JJ. Issues for DSM-V: Internet Addiction. Am J Psychiatry. 2008;165:306-307.
2. Aboujaoude E, Koran LM, Gamel N, Large MD, Serpe RT. Potential markers for problematic internet use: a telephone survey of 2,513 adults. CNS Spectr. 2006;11:750-755.
3. Yen JY, Ko CH, Yen CF, Wu HY, Yang MJ. The Comorbid Psychiatric Symptoms of Internet Addiction: Attention Deficit and Hyperactivity Disorder (ADHD), Depression, Social Phobia, and Hostility. J Adolesc Health. 2007;41:93-98.
4. Ferraro G, Caci B, D'Amico A, Di Blasi M. Internet addiction disorder: an Italian study. Cyberpsychol Behav. 2007;10:170-175.
5. Ko YS, Kim SJ, Kim BG. National Research of Internet Addiction. Seoul, Korea: Korea Agency Digital Oppotunity and Promotion; 2007.
6. Block JJ. Pathological Computer Game Use. Psychiatric Times. 2007;24. Retrieved March 1, 2007, from http://www.psychiatrictimes.com/display/article/10168/55406
7. Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W. Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. Brain Res Cogn Brain Res. 2005; 23:137-151.
8. Hollander E, Pallanti S, Baldini Rossi N, Sood E, Baker BR, Buchsbaum MS. Imaging monetary reward in pathological gamblers. World J Biol Psychiatry. 2005;6:113-120.
9. Johansson A, Gotestam KG. Problems with computer games without monetary reward: similarity to pathological gambling. Psychol Rep. 2004;95:641-650.
10. Shapira NA, Goldsmith TD, Keck PE Jr, Khosla UM, McElroy SL. Psychiatric features of individuals with problematic internet use. J Affect Disord. 2000;57:267-272.
11. Han DH, Lee YS, Yang KC, Kim EY, Lyoo IK, Renshaw PF. Dopamine Genes and Reward Dependence in Adolescents with Excessive Internet Video Game Play. J Addict Med. 2007;1:133-138.
12. Kim SH, Ahn Cl. Personality trait and Decision-Making of Addicted Internet Game Users. Korean J Health Psych. 2005;10:415-430.
13. Oh K, Kim Y, Jang K, et al. Operation of the Internet Game Addiction Center and the eEementary Study for Development of the Internet Game Addiction Scale. Seoul, Korea: Korea Agency Digital Opportunity and Promotion; 2005.
14. Patton J H, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51:768-774.
15. Soloff PH, Meltzer CC, Becker C, Greer PJ, Kelly TM, Constantine D. Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Res. 2003;123:153-163.
16. Goldstein RZ, Volkow ND, Wang GJ, Fowler JS, Rajaram S. Addiction changes orbitofrontal gyrus function: involvement in response inhibition. NeuroReport. 2001;12:2595-2629.
17. Bolla KI, Eldreth DA, London ED, et al. Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage. 2003;19:1085-1094.
18. London ED, Ernst M, Grant S, Bonson K, Weinstein A. Orbitofrontal cortex and human drug abuse: functional imaging. Cereb Cortex. 2000;10:334-342.
19. London ED, Simon SL, Berman SM, et al. Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Arch Gen Psychiatry. 2004;61:73-84.
20. Salat DH, Kaye JA, Janowsky JS. Greater orbital prefrontal volume selectively predicts worse working memory performance in older adults. Cereb Cortex. 2002;12:494-505.
21. Hyman SE, Malenka RC. Addiction and the brain: The neurobiology of compulsion and its persistence. Nat Rev Neurosci. 2001;2:695-703.
22. Robbins TW, Everitt BJ. Drug addiction: bad habits add up. Nature. 1999;398:567-570.
23. Volkow ND, Fowler JS, Wang G-J, Goldstein RZ. Role of Dopamine, the Frontal Cortex and Memory Circuits in Drug Addiction: Insight from Imaging Studies. Neurobiol Learn Mem. 2002;78:610-624.
24. Reuter J, Raedler T, Rose M, Hand I, Gläscher J, Büchel C. Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci. 2005;8:147-148.
25. Chang L, Haning W. Insights from recent positron emission tomographic studies of drug abuse and dependence. Curr Opin Psychiatry. 2006;19:246-252.
26. Volkow ND, Fowler JS. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex. 2000;10:318-325.
27. Naqvi NH, Bechara A. The hidden island of addiction: the insula. Trends Neurosci. 2009;32:56-67.
28. Brody AL, Mandelkern MA, London ED, et al. Brain metabolic changes during cigarette craving. Arch Gen Psychiatry. 2002;59:1162-1172.
29. Brody AL, Mandelkern MA, Olmstead RE, et al. Neural substrates of resisting craving during cigarette cue exposure. Biol Psychiatry. 2007;62:642-651.
30. Franklin TR, Wang Z, Wang J, et al. Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study. Neuropsychopharmacology. 2007;32:2301-2309.
31. Kilts CD, Schweitzer JB, Quinn CK, et al. Neural activity related to drug craving in cocaine addiction. Arch Gen Psychiatry. 2001;58:334-341.
32. Wang GJ, Volkow ND, Fowler JS, et al. Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sci. 1999;64:775-784.
33. Myrick H, Anton RF, Li X, et al. Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving. Neuropsychopharmacology. 2004;29:393-402.
34. Tapert SF, Brown GG, Baratta MV, Brown SA. fMRI BOLD response to alcohol stimuli in alcohol dependent young women. Addict Behav. 2004;29:33-50.
35. Naqvi NH, Rudrauf D, Damasio H, Bechara A. Damage to the insula disrupts addiction to cigarette smoking. Science. 2007;315:531-534.
36. Ko CH, Liu GC, Hsiao S, et al. Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res. 2009;43:739-747.
37. Verdejo-Garcia A, Perez-Garcia M, Bechara A. Emotion, Decision-Making and Substance Dependence: A Somatic-Marker Model of Addiction. Curr Neuropharmacol. 2006;4:17-31.
38. Crockford DN, Goodyear B, Edwards J, Quickfall J, el-Guebaly N. Cue-induced brain activity in pathological gamblers. Biol Psychiatry. 2005;58:787-795.
39. Wang Z, Faith M, Patterson F, et al. Neural substrates of abstinence-induced cigarette cravings in chronic smokers. J Neurosci. 2007;27:14035-14040.
40. Ng BD, Wiemer-hastings P. Addiction to the Internet and Online Gaming. Cyber Psychology & Behavior. 2005;8:110-113.
41. Griffiths MD, Davies MN, Chappel D. Demographic Factors and Playing Variables in Online Computer Gaming. Cyber Psychology & Behavior. 2004;7:479-487.