Panel discussion: Alternative mouse models for carcinogenicity assessment

Toxicologic Pathology

Volumn 38, Issue 1, 2010, Pages 72-75

  French, John E ^a   Leblanc, Bernard ^b   Long, Gerald G ^c   Morton, Daniel ^b   Storer, Richard ^d   Leighton, John ^e   Swenberg, James ^f   Tsuda, Hiroyuki ^g  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b PFIZER INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^f UNIVERSITY OF NORTH CAROLINA   (United States)

^g NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Animal models; Assessment risk management; Carcinogenesis; Genetically engineered mice; Preclinical safety

Indexed keywords

METHYLNITROSOUREA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; URETHAN; VINYL CHLORIDE;

ANGIOSARCOMA; CANCER MODEL; CANCER RESEARCH; CARCINOGEN TESTING; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONFERENCE PAPER; EUROPE; GENOTOXICITY; GENOTYPE; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; ARTICLE; DISEASE MODEL; HUMAN; METHODOLOGY; MOUSE;

ANIMALIA; MUS;

ANIMALS; CARCINOGENICITY TESTS; DISEASE MODELS, ANIMAL; HUMANS; MICE;

EID: 77952303735     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309352091     Document Type: Conference Paper

References (3)

1. CHMP SafetyWorking Party (2004). CHMP SWP conclusions and recommendations on the use of genetically modified animal models for carcinogenicity assessment. http://www.emea.europa.eu/pdfs/human/swp/259202enpdf. Accessed July 2, 2009.
2. International Conference on Harmonization. 1998. Carcinogenicity: Testing for Carcinogenicity or Pharmaceuticals (ICH Topic S1B). Available at http://www.emea.europa.eu/pdfs/human/ich/029995en.pdf. Accessed July 2, 2009.
3. van der Laan, J. W., Silva Lima, B., and Snodin, D. (2002). Alternative models in carcinogenicity testing-a European perspective. Toxicol Pathol 30, 157-159