An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells

Phytomedicine

Volumn 17, Issue 8-9, 2010, Pages 653-658

  Vanachayangkul, P ^a   Byer, K ^b   Khan, S ^b   Butterweck, V ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b Department of Clinical and Health Psychology   (United States)

Author keywords

Ammi visnaga; Calcium oxalate; Hyperoxaluria; Khellin; Nephrolithiasis; Visnagin

Indexed keywords

AMMI VISNAGA EXTRACT; KHELLIN; LACTATE DEHYDROGENASE; OXALIC ACID; VISNAGIN; WHEWELLITE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME RELEASE; EPITHELIUM CELL; FRUIT; KIDNEY EPITHELIUM; NEPHROLITHIASIS; NONHUMAN; PRIORITY JOURNAL; SOLVENT EXTRACTION;

AMMI; ANIMALS; CALCIUM OXALATE; CELL LINE; CELL SURVIVAL; DOGS; EPITHELIAL CELLS; FRUIT; KHELLIN; KIDNEY; KIDNEY CALCULI; L-LACTATE DEHYDROGENASE; LLC-PK1 CELLS; OXALATES; OXALIC ACID; PLANT EXTRACTS; SWINE;

AMMI VISNAGA;

EID: 77952293187     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.10.011     Document Type: Article

References (33)

1. Abeysekera B.F., Abramowski Z., and Towers G.H. Genotoxicity of the natural furochromones, khellin and visnagin and the identification of a khellin-thymine photoadduct. Photochem. Photobiol. 38 (1983) 311-315
2. Butterweck V., and Khan S.R. Herbal medicines in the management of urolithiasis: alternative or complementary?. Planta Med. 75 (2009) 1095-1103
3. Cassuto E., Gross N., Bardwell E., and Howard-Flanders P. Genetic effects of photoadducts and photocross-links in the DNA of phage lambda exposed to 360 nm light and tri-methylpsoralen or khellin. Biochim. Biophys. Acta 475 (1977) 589-600
4. Coe F.L., Evan A., and Worcester E. Kidney stone disease. J. Clin. Invest. 115 (2005) 2598-2608
5. Dellabella M., Milanese G., and Muzzonigro G. Medical-expulsive therapy for distal ureterolithiasis: randomized prospective study on role of corticosteroids used in combination with tamsulosin-simplified treatment regimen and health-related quality of life. Urology 66 (2005) 712-715
6. Gstraunthaler G., Pfaller W., and Kotanko P. Biochemical characterization of renal epithelial cell cultures (LLC-PK1 and MDCK). Am. J. Physiol. 248 (1985) F536-0
7. Gstraunthaler G., Steinmassl D., and Pfaller W. Renal cell cultures: a tool for studying tubular function and nephrotoxicity. Toxicol. Lett. 53 (1990) 1-7
8. Gunaydin K., and Beyazit N. The chemical investigations on the ripe fruits of Ammi visnaga (LAM.) Lamarck growing in Turkey. Nat. Prod. Res. 18 (2004) 169-175
9. Hackett R.L., Shevock P.N., and Khan S.R. Cell injury associated calcium oxalate crystalluria. J Urol. 144 (1990) 1535-1538
10. Huang H.S., Ma M.C., Chen J., and Chen C.F. Changes in the oxidant-antioxidant balance in the kidney of rats with nephrolithiasis induced by ethylene glycol. J. Urol. 167 (2002) 2584-2593
11. Jonassen J.A., Cao L.C., Honeyman T., and Scheid C.R. Intracellular events in the initiation of calcium oxalate stones. Nephron Exp. Nephrol. 98 (2004) E61-E64
12. Khan S.R. Calcium-oxalate crystal interaction with renal tubular epithelium, mechanism of crystal adhesion and its impact on stone development. Urol. Res. 23 (1995) 71-79
13. Khan S.R. Renal tubular damage/dysfunction: key to the formation of kidney stones. Urol. Res. 34 (2006) 86-91
14. Khan S.R., and Kok D.J. Modulators of urinary stone formation. Front. Biosci. 9 (2004) 1450-1482
15. Khan S.R., Shevock P.N., and Hackett R.L. Membrane-associated crystallization of calcium oxalate in vitro. Calcif. Tissue Int. 46 (1990) 116-120
16. Khan Z.A., Assiri A.M., Al-Afghani H.M., and Maghrabi T.M. Inhibition of oxalate nephrolithiasis with Ammi visnaga (AI-Khillah). Int. Urol. Nephrol. 33 (2001) 605-608
17. Koul H., Kennington L., Honeyman T., Jonassen J., Menon M., and Scheid C. Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cells. Kidney Int 50 (1996) 1525-1530
18. Moe O.W. Kidney stones: pathophysiology and medical management. Lancet 367 (2006) 333-344
19. Morliere P., Honigsmann H., Averbeck D., Dardalhon M., Huppe G., Ortel B., Santus R., and Dubertret L. Phototherapeutic, photobiologic, and photosensitizing properties of khellin. J. Invest. Dermatol. 90 (1988) 720-724
20. Sarica K., Yagci F., Bakir K., Erbagci A., Erturhan S., and Ucak R. Renal tubular injury induced by hyperoxaluria: evaluation of apoptotic changes. Urol. Res. 29 (2001) 34-37
21. Scheid C., Honeyman T., Kohjimoto Y., Cao L.C., and Jonassen J. Oxalate-induced changes in renal epithelial cell function: role in stone disease. Mol. Urol. 4 (2000) 371-382
22. Scheid C., Koul H., Hill W.A., Luber-Narod J., Jonassen J., Honeyman T., Kennington L., Kohli R., Hodapp J., Ayvazian P., and Menon M. Oxalate toxicity in LLC-PK1 cells, a line of renal epithelial cells. J. Urol. 155 (1996) 1112-1116
23. Schepers M.S., van Ballegooijen E.S., Bangma C.H., and Verkoelen C.F. Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells. Kidney Int. 68 (2005) 1543-1553
24. Schepers M.S., van Ballegooijen E.S., Bangma C.H., and Verkoelen C.F. Oxalate is toxic to renal tubular cells only at supraphysiologic concentrations. Kidney Int. 68 (2005) 1660-1669
25. Selvam R. Calcium oxalate stone disease: role of lipid peroxidation and antioxidants. Urol. Res. 30 (2002) 35-47
26. Thamilselvan S., Byer K.J., Hackett R.L., and Khan S.R. Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells. J. Urol. 164 (2000) 224-229
27. Thamilselvan S., Hackett R.L., and Khan S.R. Cells of proximal and distal tubular origin respond differently to challenges of oxalate and calcium oxalate crystals. J. Am. Soc. Nephrol. 10 Suppl. 14 (1999) S452-0
28. Thamilselvan S., and Khan S.R. Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies. J. Nephrol. 11 Suppl. 1 (1998) 66-69
29. Thamilselvan S., Khan S.R., and Menon M. Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol. Res. 31 (2003) 3-9
30. Vedaldi D., Caffieri S., Dall'Acqua F., Andreassi L., Bovalini L., and Martelli P. Khellin, a naturally occurring furochromone, used for the photochemotherapy of skin diseases: mechanism of action. Farmaco Sci. 43 (1988) 333-346
31. Verkoelen C.F., van der Boom B.G., Schroder F.H., and Romijn J.C. Cell cultures and nephrolithiasis. World J. Urol. 15 (1997) 229-235
32. Wiessner J.H., Hasegawa A.T., Hung L.Y., Mandel G.S., and Mandel N.S. Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells. Kidney Int. 59 (2001) 637-644
33. Worcester E.M., and Coe F.L. Nephrolithiasis. Prim. Care 35 (2008) 369-391