The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients

Neurochemistry International

Volumn 56, Issue 6-7, 2010, Pages 736-739

  Morikawa, Tomomi ^a   Manabe, Takayuki ^a   Ito, Yoshihito ^b,d   Yamada, Shinnosuke ^b,c   Yoshimi, Akira ^b,c   Nagai, Taku ^c   Ozaki, Norio ^b,d   Mayeda, Akila ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MEIJO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

HMGA1a; Lymphoblastoid; Schizophrenia

Indexed keywords

HIGH MOBILITY GROUP A1A PROTEIN; HIGH MOBILITY GROUP A1B PROTEIN; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL IMMORTALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; CELL LINE, TRANSFORMED; CELL NUCLEUS; GENE EXPRESSION; HMGA1A PROTEIN; HMGA1B PROTEIN; HUMANS; IMMUNOBLOTTING; LYMPHOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHIZOPHRENIA; UP-REGULATION;

EID: 77952292585     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.03.011     Document Type: Article

References (22)

1. Costain W.J., Mishra R.K. PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. Peptides 2003, 24:137-146.
2. Higashide S., Morikawa K., Okumura M., Kondo S., Ogata M., Murakami T., Yamashita A., Kanemoto S., Manabe T., Imaizumi K. Identification of regulatory cis-acting elements for alternative splicing of presenilin 2 exon 5 under hypoxic stress conditions. J. Neurochem. 2004, 91:1191-1198.
3. Makinodan M., Tatsumi K., Manabe T., Yamauchi T., Makinodan E., Matsuyoshi H., Shimoda S., Noriyama Y., Kishimoto T., Wanaka A. Maternal immune activation in mice delays myelination and axonal development in the hippocampus of the offspring. J. Neurosci. Res. 2008, 86:2190-2200.
4. Manabe T., Kitayama T., Ogita K., Yoneda Y. Differential expression and phosphorylation of particular fos family members by kainate in nuclear and cytosolic fractions of murine hippocampus. Neuroscience 2000, 100:453-463.
5. Manabe T., Katayama T., Sato N., Kudo T., Matsuzaki S., Imaizumi K., Tohyama M. The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients. Neurosci. Lett. 2002, 328:198-200.
6. Manabe T., Katayama T., Sato N., Gomi F., Hitomi J., Yanagita T., Kudo T., Honda A., Mori Y., Matsuzaki S., Imaizumi K., Mayeda A., Tohyama M. Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease. Cell Death Differ. 2003, 10:698-708.
7. Manabe T., Tatsumi K., Inoue M., Matsuyoshi H., Makinodan M., Yokoyama S., Wanaka A. L3/Lhx8 is involved in the determination of cholinergic or GABAergic cell fate. J. Neurochem. 2005, 94:723-730.
8. Manabe T., Tatsumi K., Inoue M., Makinodan M., Yamauchi T., Makinodan E., Yokoyama S., Sakumura R., Wanaka A. L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells. Cell Death Differ. 2007, 14:1080-1085.
9. Manabe T., Ohe K., Katayama T., Matsuzaki S., Yanagita T., Okuda H., Bando Y., Imaizumi K., Reeves R., Tohyama M., Mayeda A. HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA. Genes Cells 2007, 12:1179-1191.
10. Manabe T., Katayama T., Tohyama M. HMGA1a recognition candidate DNA sequences in humans. PLoS One 2009, 4:e8004.
11. Matsuzaki S., Manabe T., Katayama T., Nishikawa A., Yanagita T., Okuda H., Yasuda Y., Miyata S., Meshitsuka S., Tohyama M. Metals accelerate production of the aberrant splicing isoform of the presenilin-2. J. Neurochem. 2004, 88:1345-1351.
12. Nicodemus K.K., Marenco S., Batten A.J., Vakkalanka R., Egan M.F., Straub R.E., Weinberger D.R. Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk. Mol. Psychiatry 2008, 13:873-877.
13. Nishikawa A., Manabe T., Katayama T., Kudo T., Matsuzaki S., Yanagita T., Okuda H., Bando Y., Tohyama M. Novel function of PS2V: change in conformation of tau proteins. Biochem. Biophys. Res. Commun. 2004, 318:435-438.
14. Ohe, K., Mayeda, A., in press. HMGA1a trapping of U1 snRNP at an authetic 5′ splice site induces aberrant exon skipping in spordadic Alzheimer's disease. Mol. Cell. Biol. doi:10.1128/MCB.00114-10.
15. Okuda H., Manabe T., Yanagita T., Matsuzaki S., Bando Y., Katayama T., Wanaka A., Tohyama M. Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina. Mol. Cell. Neurosci. 2006, 33:81-87.
16. Rapoport J.L., Addington A.M., Frangou S., Psych M.R. The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry 2005, 10:434-449.
17. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear funcrion. Gene 2001, 277:63-81.
18. Sato N., Hori O., Yamaguchi A., Lambert J.C., Chartier-Harlin M.C., Robinson P.A., Delacourte A., Schmidt A.M., Furuyama T., Imaizumi K., Tohyama M., Takagi T. A novel presenilin-2 splice variant in human Alzheimer's disease brain tissue. J. Neurochem. 1999, 72:2498-2505.
19. Sato N., Imaizumi K., Manabe T., Taniguchi M., Hitomi J., Katayama T., Yoneda T., Morihara T., Yasuda Y., Takagi T., Kudo T., Tsuda T., Itoyama Y., Makifuchi T., Fraser P.E., St George-Hyslop P., Tohyama M. Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2. J. Biol. Chem. 2001, 276:2108-2114.
20. Smith M.J., Sharples R.A., Evin G., McLean C.A., Dean B., Pavey G., Fantino E., Cotton R.G., Imaizumi K., Masters C.L., Cappai R., Culvenor J.G. Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. Mol. Brain Res. 2004, 127:128-135.
21. Vawter M.P., Atz M.E., Rollins B.L., Cooper-Casey K.M., Shao L., Byerley W.F. Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia. Human Genet. 2006, 119:558-570.
22. Yanagita T., Manabe T., Okuda H., Matsuzaki S., Bando Y., Katayama T., Tohyama M. Possible involvement of the expression and phosphorylation of N-Myc in the induction of HMGA1a by hypoxia in the human neuroblastoma cell line. Neurosci. Lett. 2005, 374:47-52.