Mechanical ventilation induces changes in exhaled breath condensate of patients without lung injury

Respiratory Medicine

Volumn 104, Issue 6, 2010, Pages 822-828

  Roca, Oriol ^a,b   Gómez Ollés, Susana ^a,b   Cruz, Maria Jesús ^a,b   Muñoz, Xavier ^a,b   Griffiths, Mark J D ^c   Masclans, Joan R ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Biomarkers; Exhaled breath condensate; Mechanical ventilation; Ventilator associated lung injury

Indexed keywords

8 ISOPROSTANE; HELIUM; NITROGEN DIOXIDE; AUTACOID; BIOLOGICAL MARKER; NITRIC OXIDE;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BREATHING MECHANICS; BREATHING RATE; CLINICAL ARTICLE; CRITICALLY ILL PATIENT; EXHALATION; FEMALE; HUMAN; LUNG COMPLIANCE; LUNG INJURY; MALE; NON INVASIVE PROCEDURE; PATIENT MONITORING; PH; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY TRACT PARAMETERS; TIME; BREATH ANALYSIS; CRITICAL ILLNESS; FORCED EXPIRATORY VOLUME; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; PROGNOSIS;

AGED; BIOLOGICAL MARKERS; BREATH TESTS; CRITICAL ILLNESS; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; NITRIC OXIDE; PROGNOSIS; RESPIRATION, ARTIFICIAL;

EID: 77952289978     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2010.01.013     Document Type: Article

References (41)

1. Pinhu L., Whitehead T., Evans T., and Griffiths M. Ventilator-associated lung injury. Lancet 361 9354 (2003) 332-340
2. Dreyfuss D., Soler P., Basset G., and Saumon G. High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 137 5 (1988) 1159-1164
3. Slutsky A.S. Ventilator-induced lung injury: from barotrauma to biotrauma. Respir Care 50 5 (2005) 646-659
4. Slutsky A.S., and Tremblay L.N. Multiple system organ failure. Is mechanical ventilation a contributing factor?. Am J Respir Crit Care Med 157 6 Pt 1 (1998) 1721-1725
5. Gajic O., Frutos-Vivar F., Esteban A., Hubmayr R.D., and Anzueto A. Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients. Intensive Care Med 31 7 (2005) 922-926
6. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 342 18 (2000) 1301-1308
7. Amato M.B., Barbas C.S., Medeiros D.M., et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338 6 (1998) 347-354
8. Villar J., Kacmarek R.M., Pérez-Méndez L., and Aguirre-Jaime A. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med 34 5 (2006) 1311-1318
9. Ranieri V.M., Suter P.M., Tortorella C., et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282 1 (1999) 54-61
10. Parsons P.E., Eisner M.D., Thompson B.T., et al. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med 33 1 (2005) 1-6
11. Gattinoni L., and Protti A. Ventilation in the prone position: for some but not for all?. CMAJ 178 9 (2008) 1174-1176
12. Horváth I., Hunt J., Barnes P.J., et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 26 (2005) 523-548
13. Moloney E.D., Mumby S.E., Gajdocsi R., et al. Exhaled breath condensate detects markers of pulmonary inflammation after cardiothoracic surgery. Am J Respir Crit Care Med 169 (2004) 64-69
14. Baldwin S.R., Simon R.H., Grum C.M., Ketai L.H., Boxer L.A., and Devall L.J. Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1 (1986) 11-14
15. Carpenter C.T., Price P.V., and Christman B.W. Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS. Chest 114 (1998) 1653-1659
16. Gessner C., Hammerschmidt S., Kuhn H., et al. Exhaled breath condensate nitrite and its relation to tidal volume in acute lung injury. Chest 124 (2003) 1046-1052
17. Gessner C., Hammerschmidt S., Kuhn H., et al. Exhaled breath condensate acidification in acute lung injury. Respir Med 97 (2003) 1188-1194
18. Sack U., Scheibe R., Wotzel M., et al. Multiplex analysis of cytokines in exhaled breath condensate. Cytometry A 69 (2006) 169-172
19. Walsh B.K., Mackey D.J., Pajewski T., Yu Y., Gaston B.M., and Hunt J.F. Exhaled-breath condensate pH can be safely and continuously monitored in mechanically ventilated patients. Respir Care 51 10 (2006) 1125-1131
20. Roca O., Gómez-Ollés S., Cruz M.J., Muñoz X., Griffiths M.J., and Masclans J.R. Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis. Crit Care 12 3 (2008) R72
21. Gessner C., Dihazi H., Brettschneider S., et al. Presence of cytokeratins in exhaled breath condensate of mechanical ventilated patients. Respir Med 102 2 (2008) 299-306
22. Bernard G.R., Artigas A., Brigham K.L., et al. The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149 (1994) 818-824
23. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22 (1996) 707-710
24. Cruz M.J., Sánchez-Vidaurre S., Romero P.V., Morell F., and Muñoz X. Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate. Chest 135 2 (2009) 462-467
25. Kostikas K., Papatheodorou G., Ganas K., Psathakis K., Panagou P., and Loudikes S. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 165 (2002) 1364-1370
26. Hunt J.F., Erwin E., Palmer L., et al. Expression and activity of pH-regulatory glutaminase in the human airway epithelium. Am J Respir Crit Care Med 165 (2002) 101-107
27. Tate S., MacGregor G., Davis M., Innes J.A., and Greening A.P. Airways in cystic fibrosis are acidified: detection by exhaled breath condensate. Thorax 57 (2002) 926-929
28. Wolthuis E.K., Choi G., Dessing M.C., et al. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology 108 1 (2008) 46-54
29. Tsangaris I., Lekka M.E., Kitsiouli E., Constantopoulos S., and Nakos G. Bronchoalveolar lavage alterations during prolonged ventilation of patients without acute lung injury. Eur Respir J 21 3 (2003) 495-501
30. Montuschi P. Isoprostanes, prostanoids and leukotrienes in exhaled breath condensate. In: Montuschi P. (Ed). New perspectives in monitoring lung inflammation. Analysis of exhaled breath condensate (2005), CRC Press, Boca Raton, FL 53-66
31. Torrego A., Cimbollek S., Hew M., and Chung K.F. No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux. Cough 19 1 (2005) 10
32. Hunt J., Yu Y., Burns J., Gaston B., et al. Identification of acid reflux cough using serial assays of exhaled breath condensate pH. Cough 11 2 (2006) 3
33. Berg J.T., Deem S., Kerr M.E., and Swenson E.R. Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces. Am J Physiol Heart Circ Physiol 279 6 (2000) H2947-H2953
34. Zhu S., Ware L.B., Geiser T., Matthay M.A., and Matalon S. Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Am J Respir Crit Care Med 163 1 (2001) 166-172
35. Kharitonov S. Nitric oxide-derived markers in exhaled breath condensate. In: Montuschi P. (Ed). New perspectives in monitoring lung inflammation. Analysis of exhaled breath condensate (2005), CRC Press, Boca Raton, FL 85-104
36. Brett S.J., and Evans T.W. Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome. Am J Respir Crit Care Med 157 3 Pt 1 (1998) 993-997
37. McClintock D.E., Ware L.B., Eisner M.D., Wickersham N., Thompson B.T., Matthay M.A., National Heart, Lung, and and Blood Institute ARDS Network. Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med 175 3 (2007) 256-262
38. Sznajder J.I., Fraiman A., Hall J.B., et al. Increased hydrogen peroxide in the expired breath of patients with acute hypoxemic respiratory failure. Chest 96 3 (1989) 606-612
39. Okazawa A., Kawikova I., Cui Z.H., Skoogh B.E., and Lötvall J. 8-Epi-PGF2alpha induces airflow obstruction and airway plasma exudation in vivo. Am J Respir Crit Care Med 155 2 (1997) 436-441
40. Prieto L., Ferrer A., Palop J., Domenech J., Llusar R., and Rojas R. Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices. Respir Med 101 8 (2007) 1715-1720
41. Wells K., Vaughan J., Pajewski T.N., et al. Exhaled breath condensate pH assays are not influenced by oral ammonia. Thorax 60 (2005) 27-31