The clinical utility of urinary neutrophil gelatinase-associated lipocalin in the neonatal ICU

Current Opinion in Pediatrics

Volumn 22, Issue 2, 2010, Pages 146-150

  Parravicini, Elvira ^a  

^a Columbia University ^*  (United States)

Author keywords

Acute kidney injury; Biomarker; Newborn; Urinary neutrophil gelatinase associated lipocalin; Very low birth weight infant

Indexed keywords

NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

CHRONIC KIDNEY DISEASE; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DISEASE MARKER; EXTRACORPOREAL CIRCULATION; HUMAN; KIDNEY FAILURE; KIDNEY INJURY; NEPHROTOXICITY; NEWBORN INTENSIVE CARE; NEWBORN SEPSIS; NONHUMAN; NORMAL VALUE; OLIGURIA; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; UPREGULATION; VERY LOW BIRTH WEIGHT;

ACUTE-PHASE PROTEINS; ADULT; BIOLOGICAL MARKERS; CRITICAL ILLNESS; HUMANS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; KIDNEY FAILURE, ACUTE;

EID: 77952283119     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e3283369e78     Document Type: Review

References (14)

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2. Mori K, Lee HT, Rapoport D, et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 2005;115:610-621. (Pubitemid 40322235)
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7. Lavery AP, Meinzen-Derr JK, Anderson E, et al. Urinary NGAL in premature infants. Pediatr Res 2008;64:423-428. This is the first study that detects the presence of NGAL in urine of VLBW infants and postulates that uNGAL concentration rises in the condition of AKI.
8. Huynh TK, Bateman DA, Parravicini E, et al. Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr Res 2009;669:528-532. This is the first study establishing uNGAL reference range in a population of healthy VLBW infants.
9. Parravicini E, Lorenz JM, Nemerofsky SL, et al. Reference range of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants: preliminary data. Am J Perinatol 2009;26:437-440. This study first reported that uNGAL concentration in healthy premature infants is similar to that of healthy children and adults.
10. Askenazi DJ, Ambalavanan N, Goldstein SL. Acute kidney injury in critically ill Newborns: what do we know? What do we need to learn? Pediatr Nephrol 2009;24:265-274. This paper is an excellent review of AKI in Newborns.
11. Iacobelli S, Bonsante F, Ferdinus C, et al. Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age <32 weeks. J Perinatol 2009;29:232-236. This study investigates the influence of maternal and neonatal factors on serum creatinine in a very large population of VLBW infants.
12. Bennett M, Dent CL, Ma Q, et al. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol 2008;3:665-673. This study demonstrates that uNGALisan early predictive marker of AKI severity in young children after CBP.
13. Kuwabara T, Mori K, Mukoyama M, et al. Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int 2009;75:285-294. An outstanding demonstration, in an animal model, of the two NGAL separate pools and their interaction in the situation of renal injury.
14. Bolignano D, Lacquaniti A, Coppolino G, et al. Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease. Clin J Am Soc Nephrol 2009;4:337-344. This study shows that uNGAL concentration reflects the degree of renal impairment in a population of adults with not-terminal CKD and predicts CKD progression to ESRD.