Extended experience with a steroid minimization immunosuppression protocol in pediatric renal transplant recipients

Pediatric Transplantation

Volumn 14, Issue 4, 2010, Pages 488-495

  Lau, Keith K ^a,b   Berg, Gerre M ^b   Schjoneman, Yolanda G ^b   Perez, Richard V ^c   Butani, Lavjay ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Pediatrics; Renal transplantation; Steroid discontinuation

Indexed keywords

BASILIXIMAB; CHOLESTEROL; GANCICLOVIR; HEMOGLOBIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; THYMOCYTE ANTIBODY; VALGANCICLOVIR; IMMUNOSUPPRESSIVE AGENT; STEROID;

ACUTE GRAFT REJECTION; ADOLESCENT; ARTICLE; BK VIRUS; CAMPYLOBACTER ENTERITIS; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LEUKOCYTE COUNT; MAINTENANCE THERAPY; MALE; MULTIPLE CYCLE TREATMENT; POSTOPERATIVE COMPLICATION; PRESCHOOL CHILD; PYELONEPHRITIS; SCHOOL CHILD; STEROID THERAPY; URINARY TRACT INFECTION; VIREMIA; ANTHROPOMETRY; BIOPSY; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; GRAFT REJECTION; IMMUNOLOGY; KIDNEY FUNCTION TEST; POSTOPERATIVE COMPLICATIONS; PROCEDURES; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ANTHROPOMETRY; BIOPSY; CHI-SQUARE DISTRIBUTION; CHILD; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; MALE; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; STEROIDS; TREATMENT OUTCOME;

EID: 77952281082     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2009.01254.x     Document Type: Article

References (18)

1. Birkeland SA. Steroid-free immunosuppression after kidney transplantation with antithymocyte globulin induction and cyclosporine and mycophenolate mofetil maintenance therapy. Transplantation 1998 : 66 : 1207 1210.
2. Rostaing L, Cantarovich D, Mourad G, et al. Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation. Transplantation. 2005 : 79 : 807 814.
3. Birkeland SA, Larsen KE, Rohr N. Pediatric renal transplantation without steroids. Pediatr Nephrol 1998 : 12 : 87 92.
4. Sarwal MM, Yorgin PD, Alexander S, et al. Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation. Transplantation 2001 : 72 : 13 21.
5. Sarwal MM, Vidhun JR, Alexander SR, Satterwhite T, Millan M, Salvatierra O Jr. Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation 2003 : 76 : 1331 1339.
6. Lau KK, Haddad MN, Berg GM, Perez RV, Butani L. Rapid steroid discontinuation for pediatric renal transplantation: A single center experience. Pediatr Transplant 2007 : 11 : 504 510.
7. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004 : 114 : 555 576.
8. Schwartz GL, Haycock GB, Edelmann CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976 : 58 : 259 263.
9. Katznelson S, Wilkinson AH, Kobashigawa JA, et al. The effect of pravastatin on acute rejection after kidney transplantation - a pilot study. Transplantation 1996 : 61 : 1469 1474.
10. Butani L, Perez RV, Gallay BJ. Success of a steroid-minimization immunosuppression protocol for renal transplantation in the presence of donor-specific antibodies. Pediatr Transplant 2009 : 13 : 624 627.
11. https://web.emmes.com/study/ped/annlrept/Annual%20Report%20-2008.pdf
12. Sarwal M, Benfield M, Ettinger R, et al. One year results of a prospective, randomized, multicenter trial of steroid avoidance in pediatric renal transplantation. Pediatr Transplant 2009 : 13 (Suppl. 1 Abstract # LB 2.
13. Grenda R, Watson A, Tompeter R. Early steroid withdrawal in paediatric kidney recipients after two doses of daclizumab induction, tacrolimus and MMF versus tacrolimus, MMF and steroid-The TWIST study. Pediatr Transplant 2009 : 13 (Suppl. 1 Abstract # 453.
14. Opelz G, Naujokat C, Daniel V, Terness P, Döhler B. Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipients. Transplantation 2006 : 81 : 1227 1233.
15. Colleen Hastings M, Wyatt RJ, Lau KK, et al. Five years' experience with thymoglobulin induction in a pediatric renal transplant population. Pediatr Transplant 2006 : 10 : 805 810.
16. Cattaneo D, Perico N, Gaspari F, Gotti E, Remuzzi G. Glucocorticoids interfere with mycophenolate mofetil bioavailability in kidney transplantation. Kidney Int 2002 : 62 : 1060 1067.
17. Malgor LA, Barrios L, De Albarenque MV, et al. Erythropoietic action of dexamethasone on the anemia associated with an experimental chronic renal failure. Acta Physiol Pharmacol Latinoam 1987 : 37 : 365 376.
18. Butani L. Prospective monitoring of lipid profiles in children receiving Pravastatin preemptively after renal transplantation. Pediatr Transplant 2005 : 9 : 746 753.