The effects of developmental lead (Pb) exposure on the expression of the CTGF and TGF-β1 in hippocampus of pups

Toxicological and Environmental Chemistry

Volumn 91, Issue 7, 2009, Pages 1375-1385

  Li, Ning ^a   Yu, Zengli ^a   Wang, Qi ^a   Zheng, Yantao ^a   Jia, Jinxia ^a   Liu, Xinxin ^a   Li, Wenjie ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

CTGF; Lead; Neurotoxicity; TGF 1

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; DRINKING WATER; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY ASSAY; NEONATAL MOUSE; NEUROTOXICITY; PB CONCENTRATION;

DEIONIZED WATER; MUSCULOSKELETAL SYSTEM; POTABLE WATER;

LEAD;

BLOOD; CONCENTRATION (COMPOSITION); DRINKING WATER; GENE; GROWTH RATE; IMMUNOASSAY; LEAD; NEUROLOGY; POLLUTION EXPOSURE; POLYMERASE CHAIN REACTION; PREGNANCY; PROTEIN; REAL TIME; RNA; RODENT; TOXICITY;

MUS;

EID: 77952275954     PISSN: 02772248     EISSN: 10290486     Source Type: Journal    
DOI: 10.1080/02772240902732407     Document Type: Article

References (37)

1. Abreu, J.G., N.I. Ketpura, B. Reversade, and E.M. De Robertis. 2002. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nature Cell Biology 4: 599-604.
2. Basha, M.R., W. Wei, M. Brydie, M. Razmiafshari, and N.H. Zawia. 2003. Lead induced developmental perturbations in hippocampal Sp1 DNA-binding are prevented by zinc supplementation. International Journal of Developmental Neuroscience 21: 1-12.
3. Beers, M.F., K.O. Solarin, S.H. Guttentag, J. Rosenbloom, A. Kormilli, L.W. Gonzales, and P.L. Ballard. 1998. TGF-beta1 inhibits surfactant component expression and epithelial cell maturation in cultured human fetal lung. Amreican Journal of Physiology 275: L950-60.
4. Bellinger, D., J. Sloman, A. Leviton, M. Rabinowitz, H.L. Needleman, and C. Waternaux. 1991. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics 87: 219-27.
5. Blom, I.E., R. Goldschmeding, and A. Leask. 2002. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biology 21: 473-82.
6. Brigstock, D.R. 1999. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocrine Reviews 20: 189-206.
7. Brigstock, D.R. 2003. The CCN family: a new stimulus package. Journal of Endocrinology 178: 169-75.
8. Burdette, L.J., and R. Goldstein. 1986. Long-term behavioral and electrophysiological changes associated with lead exposure at different stages of brain development in the rat. Brain Research 394: 101-10.
9. Centrella, M., M.C. Horowitz, J.M. Wozney, and T.L. McCarthy. 1994. Transforming growth factor-beta gene family members and bone. Endocrine Reviews 15: 27-39.
10. Cory-Slechta, D.A. 1997. Postnatal lead exposure and MK-801 sensitivity. Neurotoxicology 18: 209-20.
11. Duncan, M.R., K.S. Frazier, S. Abramson, S. Williams, H. Klapper, X. Huang, and G.R. Grotendorst. 1999a. Connective tissue growth factor mediates transforming growth factor beta induced collagen synthesis: downregulation by cAMP. Federation of American Societies for Experimental Biology Journal 13: 1774-86.
12. Gilbert, M.E., C.M. Mack, and S.M. Lasley. 1999a. The influence of developmental period of lead exposure on long-term potentiation in the adult rat dentate gyrus in vivo. Neurotoxicology 20: 57-69.
13. Gilbert, M.E., C.M. Mack, and S.M. Lasley. 1999b. Chronic developmental lead exposure and hippocampal long-term potentiation: biphasic dose-response relationship. Neurotoxicology 20: 71-82.
14. Goodman, J.H., and R.S. Sloviter. 1993. Cocaine neurotoxicity and altered neuropeptide Y immunoreactivity in the rat hippocampus; a silver degeneration and immunocytochemical study. Brain Research 616, nos. 1-2: 263-72.
15. Goyer, R.A. 1990. Transplacental transport of lead. Environmental Health Perspectives 89: 101-5.
16. Guilarte, T.R., and J.L. McGlothan. 1998. Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure. Brain Research 790: 98-107.
17. Hirata, M., H. Kosaka, and T. Yoshida. 2004. Study on the effect of lead on event-related potentials among lead-exposed workers. Industrial Health 42: 431-4.
18. Igarashi, A., H. Okochi, D.M. Bradham, and G.R. Grotendorst. 1993. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Molecular Biology of the Cell 4: 637-45.
19. Kasperczyk, A., S. Kasperczyk, S. Horak, A. Ostalowska, E. Grucka-Mamczar, E. Romuk, A. Olejek, and E. Birkner. 2004. Semen parameters in men exposed to lead and lipid peroxidation. Toxicology and Applied Pharmacology 228: 378-84.
20. Kemp, T.J., I.K. Aggeli, P.H. Sugden, and A. Clerk. 2004. Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes. Journal of Molecular and Cellular Cardiology 37: 603-6.
21. Lau, L.F., and S.C. Lam. 1999. The CCN family of angiogenic regulators: the integrin connection. Experimental Cell Research 248: 44-57.
22. Lockitch, G. 1993. Perspectives on lead toxicity. Clinical Biochemistry 26: 371-81.
23. Lossinsky, A.S., A.W. Vorbrodt, and H.M. Wisniewski. 1986. Characterization of endothelial cell transport in the developing mouse blood-brain barrier. Developmental Neuroscience 8: 61-75.
24. Matsui, Y., and J. Sadoshima. 2004. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. Journal of Molecular and Cellular Cardiology 37: 477-81.
25. Monyer, H., N. Burnashev, D.J. Laurie, B. Sakmann, and P.H. Seeburg. 1994. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-40.
26. Mykkanen, H.M., J.W. Dickerson, and M.C. Lancaster. 1979. Effect of age on the tissue distribution of lead in the rat. Toxicology and Applied Pharmacology 51: 447-54.
27. Nihei, M.K., N.L. Desmond, J.L. McGlothan, A.C. Kuhlmann, and T.R. Guilarte. 2000. N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning. Neuroscience 99: 233-42.
28. Nihei, M.K., and T.R. Guilarte. 1999. NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2{thorn} during development. Brain Research. Molecular Brain Research 66: 42-9.
29. Ohnishi, H., T. Oka, S. Kusachi, T. Nakanishi, K. Takeda, M. Nakahama, M. Doi, et al. 1998. Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats. Journal of Molecular and Cellular Cardiology 30: 2411-22.
30. Parent, J.M., T.W. Yu, R.T. Leibowitz, D.H. Geschwind, R.S. Sloviter, and D.H. Lowenstein. 1997. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. The Journal of Neuroscience: The official journal of the Society for Neuroscience 17, no.10: 3727-38.
31. Pennica, D., T.A. Swanson, J.W. Welsh, M.A. Roy, and D.A. Lawrence. 1998. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proceedings of the National Academy of Sciences of the United States of America 95: 14717-122.
32. Perbal, B. 2001. The CCN family of genes: a brief history. Molecular Pathology 54: 103-4.
33. Perbal, B. 2004. CCN proteins: multifunctional signalling regulators. Lancet 363: 62-4.
34. Reddy, G.R., and N.H. Zawia. 2000. Lead exposure alters Egr-1 DNA binding in the neonatal rat brain. International Journal of Developmental Neuroscience 18: 791-5.
35. Vorbrodt, A.W., A.S. Lossinsky, and H.M. Wisniewski. 1986. Localization of alkaline phosphatase activity in endothelia of developing and mature mouse blood-brain barrier. Developmental Neuroscience 8: 1-13.
36. Xu, L., R.B. Corcoran, J.W. Welsh, D. Pennica, and A.J. Levine. 2000. WISP-1 is a Wnt-1 and betacathenin-responsive oncogene. Genes & Development 14: 585-95.
37. Zhou, L., C.R. Dey, S.E. Wert, and J.A. Whitsett. 1996. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene. Developmental Biology 175: 227-38.