In-vivo normothermic recirculation: An update

Current Opinion in Organ Transplantation

Volumn 15, Issue 2, 2010, Pages 173-176

  García Valdecasas, Juan Carlos ^a   Fondevila, Constantino ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

Donors after cardiac death; Liver transplantation; Nonheart beating donors

Indexed keywords

BILE DUCT DISEASE; CHOLESTASIS; CLINICAL EFFECTIVENESS; GRAFT SURVIVAL; HUMAN; IN VIVO STUDY; INCIDENCE; LIVER GRAFT REJECTION; LIVER ISCHEMIA; LIVER MACHINE PERFUSION; LIVER PERFUSION; LIVER PRESERVATION; LIVER TRANSPLANTATION; ORGAN DONOR; PATIENT SAFETY; RESUSCITATION; REVIEW; SURVIVAL RATE;

ANIMALS; BODY TEMPERATURE; BRAIN DEATH; GRAFT SURVIVAL; HUMANS; LIVER TRANSPLANTATION; ORGAN PRESERVATION; PERFUSION; TIME FACTORS; TISSUE DONORS;

EID: 77952263977     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3283373488     Document Type: Review

References (11)

1. Garcia-Valdecasas JC, Tabet J, Valero R, et al. Liver conditioning after cardiac arrest: the use of normothermic recirculation in an experimental animal model. Transpl Int 1998;11:424-432. (Pubitemid 28554598)
2. Net M, Valero R, Almenara R, et al. Hepatic xanthine levels as viability predictor of livers procured from nonheart-beating donor pigs. Transplantation 2001;71:1232-1237. (Pubitemid 32507140)
3. Net M, Valero R, Almenara R, et al. The effect of normothermic recirculation is mediated by ischemic preconditioning in NHBD liver transplantation. Am J Transplant 2005;5:2385-2392. (Pubitemid 43919421)
4. Valero R, Garcia-Valdecasas JC, Tabet J, et al. Hepatic blood flow and oxygen extraction ratio during normothermic recirculation and total body cooling as viability predictors in nonheart-beating donor pigs. Transplantation 1998;66:170-176. (Pubitemid 28369995)
5. Valero R, Garcia-Valdecasas JC, Net M, et al. L-Arginine reduces liver and biliary tract damage after liver transplantation from nonheart-beating donor pigs. Transplantation 2000;70:730-737.
6. Net M, Valero R, Almenara R, et al. Hepatic preconditioning after prolonged warm ischemia by means of S-adenosyl-L-methionine administration in pig liver transplantation from nonheart-beating donors. Transplantation 2003;75:1970-1977. (Pubitemid 36793277)
7. Valero R, Cabrer C, Oppenheimer F, et al. Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from nonheart-beating donors. Transpl Int 2000;13:303-310.
8. Abt P, Crawford M, Desai N, et al. Liver transplantation from controlled nonheart-beating donors: an increased incidence of biliary complications. Transplantation 2003;75:1659-1663. (Pubitemid 36629146)
9. Maheshwari A, Maley W, Li Z, Thuluvath PJ. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl 2007;13:1645-1653.
10. Fondevila C, Hessheimer AJ, Ruiz A, et al. Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria. Am J Transplant 2007;7:1849-1855. (Pubitemid 46905436)
11. Brockmann J, Reddy S, Coussios C, et al. Normothermic perfusion a new paradigm for organ preservation. Ann Surg 2009;250:1-6. In this recent article the authors showed very clearly that hypothermia has come to its limits and the use of normothermia is mandatory if we need to recover livers for transplantation. The authors suggest the value of in-situ normothermic recirculation in order to increase the efficacy of ex-situ normothermic perfusion.