Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy

Pediatric Emergency Care

Volumn 26, Issue 5, 2010, Pages 380-381

  Minns, Alicia B ^a   Ghafouri, Nazli ^b   Clark, Richard F ^a  

^a University of California   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

Isoniazid; Pyridoxine; Seizures

Indexed keywords

BICARBONATE; DIAZEPAM; GLUCOSE; ISONIAZID; PHENOBARBITAL; PYRIDOXINE; TUBERCULOSTATIC AGENT; VITAMIN B COMPLEX;

ARTICLE; BICARBONATE BLOOD LEVEL; CASE REPORT; DOSE RESPONSE; DRUG TREATMENT FAILURE; EPILEPTIC STATE; EXTUBATION; EYE DISEASE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; GLUCOSE BLOOD LEVEL; GRAND MAL SEIZURE; HUMAN; HYPOXIA; INFANT; INTUBATION; MALE; PHYSICAL EXAMINATION; RESPIRATION DEPRESSION; SOMNOLENCE; CHEMICALLY INDUCED; DIFFERENTIAL DIAGNOSIS; DRUG OVERDOSE; INTRAVENOUS DRUG ADMINISTRATION; STATUS EPILEPTICUS;

ANTITUBERCULAR AGENTS; DIAGNOSIS, DIFFERENTIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG OVERDOSE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; ISONIAZID; MALE; PYRIDOXINE; STATUS EPILEPTICUS; VITAMIN B COMPLEX;

EID: 77952261293     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/PEC.0b013e3181db24b6     Document Type: Article

References (14)

1. Vase T, Saluja J. INH inducted status epilepticus: response to pyridoxine. Indian J Chest Dis Allied Sci. 2006;48:205-206.
2. Brown CV. Acute isoniazid poisoning. Am Rev Respir Dis. 1972;105:206.
3. Yarbrough BE, Wood JP. Isoniazid overdose treated with high-dose pyridoxine. Ann Emerg Med. 1983; 12 (5) : 303-305.
4. Wason S, Lacouture PG, Lovejoy FH. Single high-dose pyridoxine treatment for isoniazid overdose. JAMA. 1981;246:1102-1104.
5. Shah BR, Santucci K, Sinert R. Acute isoniazid neurotoxicity in an urban hospital. Pediatrics. 1995;95:700-704.
6. Erdman AR. Pyridoxine. In: Dart RC, ed. Medical Toxicology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004: 244-247.
7. Henry GC, Haynes S. Insoniazid and other antituberculous drugs. In: Ford MD, Delaney KA, Ling LJ, et al, eds. Ford: Clinical Toxicology. 1st ed. Philadelphia, PA: WB Saunders Company; 2001: 439-445.
8. Howland MA. Antidotes in depth: pyridoxine. In: Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds. Goldfrank's Toxicologic Emergencies. 8th ed. New York, NY: McGraw-Hill Companies; 2006: 872-875.
9. Sievers ML, Herrier RN. Treatment of acute isoniazid toxicity. Am J Hosp Pharm. 1975;32:202-206.
10. Albin RL, Albers JW, Greenberg HS, et al. Acute sensory neuropathy-neuronopathy from pyridoxine overdose. Neurology. 1987;37:1729-1731.
11. Schaumberg H, Kaplan J, Windebank A, et al. Sensory neuropathy from pyridoxine abuse. NEJM. 1983; 309 (8) : 445-448.
12. Chin L, Sievers ML, Laird HE, et al. Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs. Toxicol Appl Pharmacol. 1978;45:713-722.
13. Scharman EJ, Rosencrance JG. Isoniazid toxicity: a survey of pyridoxine availability. Am J Emerg Med. 1994; 12 (3) : 386-387.
14. Santucci KA, Shah BR, Linakis JG. Acute isoniazid exposures and antidote availability. Pediatr Emerg Care. 1999;15:99-101.