The Salmonella enterica serovar Typhimurium QseB response regulator negatively regulates bacterial motility and swine colonization in the absence of the QseC sensor kinase

Microbial Pathogenesis

Volumn 48, Issue 6, 2010, Pages 214-219

  Bearson, Bradley L ^a   Bearson, Shawn M D ^a   Lee, In Soo ^b   Brunelle, Brian W ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b Hannam University   (South Korea)

Author keywords

Colonization; Iron; Motility; Norepinephrine; Salmonella; Swine

Indexed keywords

BACTERIAL PROTEIN; FERRIOXAMINE; FERRIOXAMINE E; NORADRENALIN; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN CIRA; OUTER MEMBRANE PROTEIN FEPA; OUTER MEMBRANE PROTEIN IRON; SENSOR KINASE QSEB; SENSOR KINASE QSEC; SIDEROPHORE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL MOTILITY; BACTERIAL SHEDDING; CELL MOTILITY; MICROBIAL ACTIVITY; NONHUMAN; OPERON; PHENOTYPE; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SEROTYPE; SIGNAL TRANSDUCTION; SWINE DISEASE; WILD TYPE;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL SHEDDING; CHLORIDES; FECES; FEMALE; FERRIC COMPOUNDS; MALE; MUTATION; NOREPINEPHRINE; OPERON; PEPTIDES, CYCLIC; QUORUM SENSING; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SWINE;

BACTERIA (MICROORGANISMS); SALMONELLA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM; SUIDAE;

EID: 77952241133     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2010.03.005     Document Type: Article

References (27)

1. Laub M.T., Goulian M. Specificity in two-component signal transduction pathways. Annu Rev Genet 2007, 41:121-145.
2. Stock A.M., Robinson V.L., Goudreau P.N. Two-component signal transduction. Annu Rev Biochem 2000, 69:183-215.
3. Sperandio V., Torres A.G., Jarvis B., Nataro J.P., Kaper J.B. Bacteria-host communication: the language of hormones. Proc Natl Acad Sci U S A 2003, 100:8951-8956.
4. Clarke M.B., Hughes D.T., Zhu C., Boedeker E.C., Sperandio V. The QseC sensor kinase: a bacterial adrenergic receptor. Proc Natl Acad Sci U S A 2006, 103:10420-10425.
5. Freestone P.P., Haigh R.D., Williams P.H., Lyte M. Stimulation of bacterial growth by heat-stable, norepinephrine-induced autoinducers. FEMS Microbiol Lett 1999, 172:53-60.
6. Williams P.H., Rabsch W., Methner U., Voigt W., Tschape H., Reissbrodt R. Catecholate receptor proteins in Salmonella enterica: role in virulence and implications for vaccine development. Vaccine 2006, 24:3840-3844.
7. Freestone P.P., Haigh R.D., Lyte M. Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica. BMC Microbiol 2007, 7:8.
8. Methner U., Rabsch W., Reissbrodt R., Williams P.H. Effect of norepinephrine on colonisation and systemic spread of Salmonella enterica in infected animals: role of catecholate siderophore precursors and degradation products. Int J Med Microbiol 2008, 298:429-439.
9. Bearson B.L., Bearson S.M.D., Uthe J.J., Dowd S.E., Houghton J.O., Lee I.S., et al. Iron regulated genes of Salmonella enterica serovar Typhimurium in response to norepinephrine and the requirement of fepDGC for norepinephrine-enhanced growth. Microbes Infect 2008, 10:807-816.
10. Bearson B.L., Bearson S.M. The role of the QseC quorum-sensing sensor kinase in colonization and norepinephrine-enhanced motility of Salmonella enterica serovar Typhimurium. Microb Pathog 2008, 44:271-278.
11. Freestone P.P., Lyte M., Neal C.P., Maggs A.F., Haigh R.D., Williams P.H. The mammalian neuroendocrine hormone norepinephrine supplies iron for bacterial growth in the presence of transferrin or lactoferrin. J Bacteriol 2000, 182:6091-6098.
12. Merighi M., Carroll-Portillo A., Septer A.N., Bhatiya A., Gunn J.S. Role of Salmonella enterica serovar Typhimurium two-component system PreA/PreB in modulating PmrA-regulated gene transcription. J Bacteriol 2006, 188:141-149.
13. Merighi M., Septer A.N., Carroll-Portillo A., Bhatiya A., Porwollik S., McClelland M., et al. Genome-wide analysis of the PreA/PreB (QseB/QseC) regulon of Salmonella enterica serovar Typhimurium. BMC Microbiol 2009, 9:42.
14. Rabsch W., Methner U., Voigt W., Tschape H., Reissbrodt R., Williams P.H. Role of receptor proteins for enterobactin and 2,3-dihydroxybenzoylserine in virulence o f Salmonella enterica. Infect Immun 2003, 71:6953-6961.
15. Held K.G., Postle K. ExbB and ExbD do not function independently in TonB-dependent energy transduction. J Bacteriol 2002, 184:5170-5173.
16. Andrews S.C., Robinson A.K., Rodriguez-Quinones F. Bacterial iron homeostasis. FEMS Microbiol Rev 2003, 27:215-237.
17. Clarke M.B., Sperandio V. Events at the host-microbial interface of the gastrointestinal tract III. Cell-to-cell signaling among microbial flora, host, and pathogens: there is a whole lot of talking going on. Am J Physiol Gastrointest Liver Physiol 2005, 288:G1105-G1109.
18. Karavolos M.H., Spencer H., Bulmer D.M., Thompson A., Winzer K., Williams P., et al. Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses. BMC Genomics 2008, 9:458.
19. Chilcott G.S., Hughes K.T. Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar Typhimurium and Escherichia coli. Microbiol Mol Biol Rev 2000, 64:694-708.
20. Kostakioti M., Hadjifrangiskou M., Pinkner J.S., Hultgren S.J. QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Mol Microbiol 2009, 73:1020-1031.
21. Chen C., Brown D.R., Xie Y., Green B.T., Lyte M. Catecholamines modulate Escherichia coli O157:H7 adherence to murine cecal mucosa. Shock 2003, 20:183-188.
22. Wang Q., Frye J.G., McClelland M., Harshey R.M. Gene expression patterns during swarming in Salmonella typhimurium: genes specific to surface growth and putative new motility and pathogenicity genes. Mol Microbiol 2004, 52:169-187.
23. Spencer H., Karavolos M.H., Bulmer D.M., Aldridge P., Chhabra S.R., Winzer K., et al. Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella. J Bacteriol 2010, 192:714-724.
24. Rasko D.A., Moreira C.G., Li de R., Reading N.C., Ritchie J.M., Waldor M.K., et al. Targeting QseC signaling and virulence for antibiotic development. Science 2008, 321:1078-1080.
25. Vidal S.M., Malo D., Vogan K., Skamene E., Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 1993, 73:469-485.
26. Stecher B., Paesold G., Barthel M., Kremer M., Jantsch J., Stallmach T., et al. Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ mice. Infect Immun 2006, 74:5047-5057.
27. Foster J.W., Bearson B. Acid-sensitive mutants of Salmonella typhimurium identified through a dinitrophenol lethal screening strategy. J Bacteriol 1994, 176:2596-2602.