-
1
-
-
52149086562
-
AKT1 (E17K) in human solid tumours
-
Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, Scarpa A, Leenstra S, Frattini M, Barbareschi M, Del Grammastro M, Sciarotta MG, Zanon C, Marchetti A, Bardelli A (2008) AKT1 (E17K) in human solid tumours. Oncogene 27: 5648-5650
-
(2008)
Oncogene
, vol.27
, pp. 5648-5650
-
-
Bleeker, F.E.1
Felicioni, L.2
Buttitta, F.3
Lamba, S.4
Cardone, L.5
Rodolfo, M.6
Scarpa, A.7
Leenstra, S.8
Frattini, M.9
Barbareschi, M.10
Del Grammastro, M.11
Sciarotta, M.G.12
Zanon, C.13
Marchetti, A.14
Bardelli, A.15
-
2
-
-
57349171273
-
An activating mutation in AKT1 in human prostate cancer
-
Boormans JL, Hermans KG, van Leenders GJLH, Trapman J, Verhagen PCMS (2008) An activating mutation in AKT1 in human prostate cancer. Int J Cancer 123: 2725-2726
-
(2008)
Int J Cancer
, vol.123
, pp. 2725-2726
-
-
Boormans, J.L.1
Hermans, K.G.2
Van Leenders Gjlh3
Trapman, J.4
Pcms, V.5
-
3
-
-
34547574720
-
A new mutational aktivation in the PI3K pathway
-
Brugge J, Hung MC, Mills GB (2007) A new mutational aktivation in the PI3K pathway. Cancer Cell 12: 104-107
-
(2007)
Cancer Cell
, vol.12
, pp. 104-107
-
-
Brugge, J.1
Hung, M.C.2
Mills, G.B.3
-
4
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455: 1061-1068
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
5
-
-
15444349266
-
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
-
Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS, Sidransky D (1997) Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57: 4997-5000
-
(1997)
Cancer Res
, vol.57
, pp. 4997-5000
-
-
Cairns, P.1
Okami, K.2
Halachmi, S.3
Halachmi, N.4
Esteller, M.5
Herman, J.G.6
Jen, J.7
Isaacs, W.B.8
Bova, G.S.9
Sidransky, D.10
-
6
-
-
0033551070
-
New insights into tumor progression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG (1999) New insights into tumor progression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96: 4240-4245
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
7
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs S, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savaga S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, tucker-Kellog G, Touchman J, Patel K, Mousses S, Brittner M, Schevtz R, Lai MH, Blanchard KL, Thomas JE (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savaga, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.W.14
Zeckner, D.J.15
Tucker-Kellog, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Brittner, M.20
Schevtz, R.21
Lai, M.H.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
8
-
-
53849132331
-
A novel AKT3 mutation in melanoma tumours and cell lines
-
Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG, Lazar AFJ, Gershenwald JE, Mills GB (2008) A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer 99: 1265-1268
-
(2008)
Br J Cancer
, vol.99
, pp. 1265-1268
-
-
Davies, M.A.1
Stemke-Hale, K.2
Tellez, C.3
Calderone, T.L.4
Deng, W.5
Prieto, V.G.6
Lazar, A.F.J.7
Gershenwald, J.E.8
Mills, G.B.9
-
9
-
-
68549083200
-
Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
-
Do H, Solomon B, Mitchell PL, Fox SB, Dobrovic A (2008) Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. BMC Res Notes 1: 14
-
(2008)
BMC Res Notes
, vol.1
, pp. 14
-
-
Do, H.1
Solomon, B.2
Mitchell, P.L.3
Fox, S.B.4
Dobrovic, A.5
-
10
-
-
77952239869
-
Prognostic factors for and outcomes of locally advanced prostate cancer after radical prostatectomy
-
e-pub ahead of print 12 November 2009
-
Hsu CY, Wildhagen MF, van Poppel H, Bangma CH (2009) Prognostic factors for and outcomes of locally advanced prostate cancer after radical prostatectomy. BJU Int; e-pub ahead of print 12 November 2009
-
(2009)
BJU Int
-
-
Hsu, C.Y.1
Wildhagen, M.F.2
Van Poppel, H.3
Bangma, C.H.4
-
11
-
-
37249056471
-
The structure of a human p110a/p85a complex elucidates the effects of oncogenic PI3Ka mutations
-
Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM (2007) The structure of a human p110a/p85a complex elucidates the effects of oncogenic PI3Ka mutations. Science 318: 1744-1748
-
(2007)
Science
, vol.318
, pp. 1744-1748
-
-
Huang, C.H.1
Mandelker, D.2
Schmidt-Kittler, O.3
Samuels, Y.4
Velculescu, V.E.5
Kinzler, K.W.6
Vogelstein, B.7
Gabelli, S.B.8
Amzel, L.M.9
-
12
-
-
17144382038
-
Frequent mutation of the PIK3CA gene in ovarian and breast cancers
-
Levine DA, Bogomolniy F, Yee CJ, Lash A, Barakat RR, Borgen PI, Boyd J (2005) Frequent mutation of the PIK3CA gene in ovarian and breast cancers. Clin Cancer Res 11: 2875-2878
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2875-2878
-
-
Levine, D.A.1
Bogomolniy, F.2
Yee, C.J.3
Lash, A.4
Barakat, R.R.5
Borgen, P.I.6
Boyd, J.7
-
13
-
-
0030936323
-
PTEN a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
14
-
-
65949092291
-
PIK3CA mutations in human solid tumours
-
Ligresti G, Militello L, Steelman LS, Cavallaro A, Basile F, Nicoletti F, Stivala F, McCubrey JA, Libra M (2009) PIK3CA mutations in human solid tumours. Cell Cycle 8: 1352-1358
-
(2009)
Cell Cycle
, vol.8
, pp. 1352-1358
-
-
Ligresti, G.1
Militello, L.2
Steelman, L.S.3
Cavallaro, A.4
Basile, F.5
Nicoletti, F.6
Stivala, F.7
McCubrey, J.A.8
Libra, M.9
-
15
-
-
21344454216
-
Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis
-
Ma X, Ziel-van der Made A, Autar B, van der Korput A, Vermeij M, van Duijn P, Cleutjens KB, de Krijger R, Krimpenfort P, Berns A, van der Kwast TH, Trapman J (2005) Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res 65: 5730-5739
-
(2005)
Cancer Res
, vol.65
, pp. 5730-5739
-
-
Ma, X.1
Ziel-Van Der Made, A.2
Autar, B.3
Van Der Korput, A.4
Vermeij, M.5
Van Duijn, P.6
Cleutjens, K.B.7
De Krijger, R.8
Krimpenfort, P.9
Berns, A.10
Van Der Kwast, T.H.11
Trapman, J.12
-
16
-
-
27844506524
-
Akt-regulated pathways in prostate cancer
-
Majumder PK, Sellers WR (2005) Akt-regulated pathways in prostate cancer. Oncogene 24: 7465-7474
-
(2005)
Oncogene
, vol.24
, pp. 7465-7474
-
-
Majumder, P.K.1
Sellers, W.R.2
-
17
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, De Gisi S, Malara N, Savino R, Rocco G, Chiappetta G, Franco R, Tirino V, Pirozzi G, Viglietto G (2008) Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 7: 665-669
-
(2008)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
Fabiani, F.4
De Rosa, N.5
De Gisi, S.6
Malara, N.7
Savino, R.8
Rocco, G.9
Chiappetta, G.10
Franco, R.11
Tirino, V.12
Pirozzi, G.13
Viglietto, G.14
-
18
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz Jr LA, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Siu, I.M.9
Gallia, G.L.10
Olivi, A.11
McLendon, R.12
Rasheed, B.A.13
Keir, S.14
Nikolskaya, T.15
Nikolsky, Y.16
Busam, D.A.17
Tekleab, H.18
Diaz Jr, L.A.19
Hartigan, J.20
Smith, D.R.21
Strausberg, R.L.22
Marie, S.K.23
Shinjo, S.M.24
Yan, H.25
Riggins, G.J.26
Bigner, D.D.27
Karchin, R.28
Papadopoulos, N.29
Parmigiani, G.30
Vogelstein, B.31
Velculescu, V.E.32
Kinzler, K.W.33
more..
-
19
-
-
11144358645
-
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
-
DOI 10.1126/science.1096502
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554 (Pubitemid 38541907) (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
20
-
-
67649868092
-
The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
-
Shoji K, Oda K, Nakagawa S, Hosakawa S, Nagae G, Uehara Y, Sone K, Miyamoto Y, Hiraike H, Hiraike-Wada O, Nei T, Kawana K, Aburatani H, Yano T, Taketani Y (2009) The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. Br J Cancer 101: 145-148
-
(2009)
Br J Cancer
, vol.101
, pp. 145-148
-
-
Shoji, K.1
Oda, K.2
Nakagawa, S.3
Hosakawa, S.4
Nagae, G.5
Uehara, Y.6
Sone, K.7
Miyamoto, Y.8
Hiraike, H.9
Hiraike-Wada, O.10
Nei, T.11
Kawana, K.12
Aburatani, H.13
Yano, T.14
Taketani, Y.15
-
21
-
-
0031964511
-
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues
-
Suzuki H, Freije D, Nusskern DR, Okami K, Cairns P, Sidransky D, Isaacs WB, Bova GS (1998) Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res 58: 204-209
-
(1998)
Cancer Res
, vol.58
, pp. 204-209
-
-
Suzuki, H.1
Freije, D.2
Nusskern, D.R.3
Okami, K.4
Cairns, P.5
Sidransky, D.6
Isaacs, W.B.7
Bova, G.S.8
-
22
-
-
33645231294
-
The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion
-
Verhagen PC, van Duijn PW, Hermans KG, Looijenga LH, van Gurp RJ, Stoop H, van der Kwast TH, Trapman J (2006) The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion. J Pathol 208: 699-707
-
(2006)
J Pathol
, vol.208
, pp. 699-707
-
-
Verhagen, P.C.1
Van Duijn, P.W.2
Hermans, K.G.3
Looijenga, L.H.4
Van Gurp, R.J.5
Stoop, H.6
Van Der Kwast, T.H.7
Trapman, J.8
-
23
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Rev Cancer 2: 489-501
-
(2002)
Nature Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
24
-
-
0032126505
-
Frequent inactivation of PTEN in prostate cancer cell lines and xenografts
-
Vlietstra RJ, van Alewijk DC, Hermans KG, van Steenbrugge GJ, Trapman J (1998) Frequent inactivation of PTEN in prostate cancer cell lines and xenografts. Cancer Res 58: 2720-2723
-
(1998)
Cancer Res
, vol.58
, pp. 2720-2723
-
-
Vlietstra, R.J.1
Van Alewijk, D.C.2
Hermans, K.G.3
Van Steenbrugge, G.J.4
Trapman, J.5
-
25
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumour suppressor gene leads to metastatic prostate cancer
-
Wang S, Gao L, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H (2003) Prostate-specific deletion of the murine Pten tumour suppressor gene leads to metastatic prostate cancer. Cancer Cell 4: 209-221
-
(2003)
Cancer Cell
, vol.4
, pp. 209-221
-
-
Wang, S.1
Gao, L.2
Lei, Q.3
Rozengurt, N.4
Pritchard, C.5
Jiao, J.6
Thomas, G.V.7
Li, G.8
Roy-Burman, P.9
Nelson, P.S.10
Liu, X.11
Wu, H.12
-
26
-
-
0032574718
-
Inactivation of the tumour suppressor PTEN/MMAC1 in advanced prostate cancer through loss of expression
-
Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, Said JW, Isaacs WB, Sawyers CL (1998) Inactivation of the tumour suppressor PTEN/MMAC1 in advanced prostate cancer through loss of expression. Proc Natl Acad Sci USA 95: 5246-5250
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
Wu, X.2
Suzuki, H.3
Reiter, R.E.4
Tran, C.5
Vessella, R.L.6
Said, J.W.7
Isaacs, W.B.8
Sawyers, C.L.9
-
27
-
-
64849084242
-
AKT1 E17K pleckstrin homology domain in urothelial carcinoma
-
Zilberman DE, Cohen Y, Amariglio N, Fridman E, Ramon J, Rechavi G (2009) AKT1 E17K pleckstrin homology domain in urothelial carcinoma. Cancer Genet Cytogenet 191: 34-37
-
(2009)
Cancer Genet Cytogenet
, vol.191
, pp. 34-37
-
-
Zilberman, D.E.1
Cohen, Y.2
Amariglio, N.3
Fridman, E.4
Ramon, J.5
Rechavi, G.6
|