메뉴 건너뛰기




Volumn 88, Issue 4, 2010, Pages 351-360

Langerhans cells: Critical regulators of skin immunity

Author keywords

Contact hypersensitivity; Dendritic cell; Interleukin 10; Langerhans cell; Transforming growth factor ; UV radiation

Indexed keywords

INTERLEUKIN 10; LANGERIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77952220955     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2010.40     Document Type: Review
Times cited : (70)

References (125)
  • 2
    • 36248965712 scopus 로고    scopus 로고
    • Dendritic cells: Understanding immunogenicity
    • Steinman RM. Dendritic cells: understanding immunogenicity. Eur J Immunol 2007; 37(Suppl 1): S53-S60.
    • (2007) Eur J Immunol , vol.37 , Issue.SUPPL. 1
    • Steinman, R.M.1
  • 3
    • 0015619335 scopus 로고
    • Identification of a novel cell type in peripheral lymphoid organs of mice.I. Morphology, quantitation, tissue distribution
    • Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J ExpMed 1973; 137: 1142-1162.
    • (1973) J ExpMed , Issue.137 , pp. 1142-1162
    • Steinman, R.M.1    Cohn, Z.A.2
  • 4
    • 34447605625 scopus 로고
    • Ueber die Nerven der menschlichen Haut
    • Langerhans P. Ueber die Nerven der menschlichen Haut. Virchows Arch 1968; 44: 325-337.
    • (1968) Virchows Arch , vol.44 , pp. 325-337
    • Langerhans, P.1
  • 5
    • 0021917676 scopus 로고
    • Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro
    • DOI 10.1084/jem.161.3.526
    • Schuler G, Steinman RM. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells. In vitro. J Exp Med 1985; 161: 526-546. (Pubitemid 15142803)
    • (1985) Journal of Experimental Medicine , vol.161 , Issue.3 , pp. 526-546
    • Schuler, G.1    Steinman, R.M.2
  • 6
    • 1642379407 scopus 로고    scopus 로고
    • Lymphoid organ dendritic cells: Beyond the Langerhans cells paradigm
    • Wilson NS, Villadangos JA. Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm. Immunol Cell Biol 2004; 82: 91-98.
    • (2004) Immunol Cell Biol , vol.82 , pp. 91-98
    • Wilson, N.S.1    Villadangos, J.A.2
  • 7
    • 0024549594 scopus 로고
    • Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells
    • Romani N, Koide S, Crowley M, Witmer-Pack M, Livingstone AM, Fathman CG et al. Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 1989; 169: 1169-1178.
    • (1989) J Exp Med , vol.169 , pp. 1169-1178
    • Romani, N.1    Koide, S.2    Crowley, M.3    Witmer-Pack, M.4    Livingstone, A.M.5    Fathman, C.G.6
  • 8
    • 0027305137 scopus 로고
    • Phagocytosis of antigens by Langerhans cells in vitro
    • Reise Sousa C, Stahl PD, Austyn JM. Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med 1993; 178: 509-519.
    • (1993) J Exp Med , vol.178 , pp. 509-519
    • Reise Sousa, C.1    Stahl, P.D.2    Austyn, J.M.3
  • 9
    • 0030869567 scopus 로고    scopus 로고
    • Developmental regulation of MHC class II transport in mouse dendritic cells
    • Pierre P, Turley SJ, Gatti E, Hull M, Meltzer J, Mirza A et al. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 1997; 388: 787-792.
    • (1997) Nature , vol.388 , pp. 787-792
    • Pierre, P.1    Turley, S.J.2    Gatti, E.3    Hull, M.4    Meltzer, J.5    Mirza, A.6
  • 10
    • 0018580178 scopus 로고
    • Epidermal Langerhans cells are derived from cells originating in bone marrow
    • Katz SI, Tamaki K, Sachs DH. Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature 1979; 282: 324-326.
    • (1979) Nature , vol.282 , pp. 324-326
    • Katz, S.I.1    Tamaki, K.2    Sachs, D.H.3
  • 11
    • 0018580176 scopus 로고
    • Mouse epidermal Ia molecules have a bone marrow origin
    • Frelinger JG, Hood L, Hill S, Frelinger JA. Mouse epidermal Ia molecules have a bone marrow origin. Nature 1979; 282: 321-323.
    • (1979) Nature , vol.282 , pp. 321-323
    • Frelinger, J.G.1    Hood, L.2    Hill, S.3    Frelinger, J.A.4
  • 12
    • 0018176271 scopus 로고
    • Immunologic functions of Ia-bearing epidermal Langerhans cells
    • Stingl G, Katz SI, Clement L, Green I, Shevach EM. Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 1978; 121: 2005-2013.
    • (1978) J Immunol , vol.121 , pp. 2005-2013
    • Stingl, G.1    Katz, S.I.2    Clement, L.3    Green, I.4    Shevach, E.M.5
  • 13
    • 0020624161 scopus 로고
    • Epidermal cell-induced generation of cytotoxic T-lymphocyte responses against alloantigens or TNP-modified syngeneic cells: Requirement for Ia-positive Langerhans cells
    • Pehamberger H, Stingl LA, Pogantsch S, Steiner G, Wolff K, Stingl G. Epidermal cell-induced generation of cytotoxic T-lymphocyte responses against alloantigens or TNP-modified syngeneic cells: requirement for Ia-positive Langerhans cells. J Invest Dermatol 1983; 81: 208-211.
    • (1983) J Invest Dermatol , vol.81 , pp. 208-211
    • Pehamberger, H.1    Stingl, L.A.2    Pogantsch, S.3    Steiner, G.4    Wolff, K.5    Stingl, G.6
  • 15
    • 73949120263 scopus 로고    scopus 로고
    • External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
    • Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M. External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J Exp Med 2009; 206: 2937-2946.
    • (2009) J Exp Med , vol.206 , pp. 2937-2946
    • Kubo, A.1    Nagao, K.2    Yokouchi, M.3    Sasaki, H.4    Amagai, M.5
  • 16
    • 0027530547 scopus 로고
    • Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin
    • Tang A, Amagai M, Granger LG, Stanley JR, Udey MC. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 1993; 361: 82-85.
    • (1993) Nature , vol.361 , pp. 82-85
    • Tang, A.1    Amagai, M.2    Granger, L.G.3    Stanley, J.R.4    Udey, M.C.5
  • 17
    • 4143096772 scopus 로고    scopus 로고
    • CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
    • Ohl L, Mohaupt M, Czeloth N, Hintzen G, Kiafard Z, Zwirner J et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 2004; 21: 279-288.
    • (2004) Immunity , vol.21 , pp. 279-288
    • Ohl, L.1    Mohaupt, M.2    Czeloth, N.3    Hintzen, G.4    Kiafard, Z.5    Zwirner, J.6
  • 18
    • 77349112874 scopus 로고    scopus 로고
    • Langerhans cells and more: Langerin-expressing dendritic cell subsets in the skin
    • Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 2010; 234: 120-141.
    • Immunol Rev , vol.2010 , Issue.234 , pp. 120-141
    • Romani, N.1    Clausen, B.E.2    Stoitzner, P.3
  • 19
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker T, Riedinger M, Karjalinen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 1997; 185: 541-550.
    • (1997) J Exp Med , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalinen, K.3
  • 20
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman RM, Turley S, Mellman I, Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000; 191: 411-416.
    • (2000) J Exp Med , vol.191 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 21
    • 0034614894 scopus 로고    scopus 로고
    • A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
    • Huang FP, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 2000; 191: 435-444.
    • (2000) J Exp Med , vol.191 , pp. 435-444
    • Huang, F.P.1    Platt, N.2    Wykes, M.3    Major, J.R.4    Powell, T.J.5    Jenkins, C.D.6
  • 23
    • 0035002521 scopus 로고    scopus 로고
    • Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factorbeta1- dependent cells
    • Hemmi H, Yoshino M, Yamazaki H, Naito M, Iyoda T, Omatsu Y et al. Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factorbeta1- dependent cells. Int Immunol 2001; 13: 695-704.
    • (2001) Int Immunol , vol.13 , pp. 695-704
    • Hemmi, H.1    Yoshino, M.2    Yamazaki, H.3    Naito, M.4    Iyoda, T.5    Omatsu, Y.6
  • 24
    • 0035903326 scopus 로고    scopus 로고
    • Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    • Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001; 194: 769-779.
    • (2001) J Exp Med , vol.194 , pp. 769-779
    • Hawiger, D.1    Inaba, K.2    Dorsett, Y.3    Guo, M.4    Mahnke, K.5    Rivera, M.6
  • 25
    • 0037122011 scopus 로고    scopus 로고
    • Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class i products and peripheral CD8+ T cell tolerance
    • Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002; 196: 1627-1638.
    • (2002) J Exp Med , vol.196 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 26
    • 0037039379 scopus 로고    scopus 로고
    • Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
    • Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 2002; 99: 351-358.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 351-358
    • Steinman, R.M.1    Nussenzweig, M.C.2
  • 27
    • 35348968837 scopus 로고    scopus 로고
    • Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
    • Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S et al. Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity 2007; 27: 610-624.
    • (2007) Immunity , vol.27 , pp. 610-624
    • Jiang, A.1    Bloom, O.2    Ono, S.3    Cui, W.4    Unternaehrer, J.5    Jiang, S.6
  • 28
    • 0141678970 scopus 로고    scopus 로고
    • Most lymphoid organ dendritic cell types are phenotypically and functionally immature
    • Wilson NS, El-Sukkari D, Belz GT, Smith CM, Steptoe RJ, Heath WR et al. Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood 2003; 102: 2187-2194.
    • (2003) Blood , vol.102 , pp. 2187-2194
    • Wilson, N.S.1    El-Sukkari, D.2    Belz, G.T.3    Smith, C.M.4    Steptoe, R.J.5    Heath, W.R.6
  • 29
    • 0141654300 scopus 로고    scopus 로고
    • Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    • Allan RS, Smith CM, Belz GT, van Lint AL, Wakim LM, Heath WR et al. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science 2003; 301: 1925-1928.
    • (2003) Science , vol.301 , pp. 1925-1928
    • Allan, R.S.1    Smith, C.M.2    Belz, G.T.3    Van Lint, A.L.4    Wakim, L.M.5    Heath, W.R.6
  • 30
    • 33746027329 scopus 로고    scopus 로고
    • Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
    • Allan RS, Waithman J, Bedoui S, Jones CM, Villadangos JA, Zhan Y et al. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 2006; 25: 153-162.
    • (2006) Immunity , vol.25 , pp. 153-162
    • Allan, R.S.1    Waithman, J.2    Bedoui, S.3    Jones, C.M.4    Villadangos, J.A.5    Zhan, Y.6
  • 31
    • 0037455066 scopus 로고    scopus 로고
    • Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2
    • Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, Zhu J et al. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med 2003; 197: 153-162.
    • (2003) J Exp Med , vol.197 , pp. 153-162
    • Zhao, X.1    Deak, E.2    Soderberg, K.3    Linehan, M.4    Spezzano, D.5    Zhu, J.6
  • 32
    • 13544268716 scopus 로고    scopus 로고
    • Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells
    • Bosnjak L, Miranda-Saksena M, Koelle DM, Boadle RA, Jones CA, Cunningham AL. Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells. J Immunol 2005; 174: 2220-2227.
    • (2005) J Immunol , vol.174 , pp. 2220-2227
    • Bosnjak, L.1    Miranda-Saksena, M.2    Koelle, D.M.3    Boadle, R.A.4    Jones, C.A.5    Cunningham, A.L.6
  • 33
    • 7644229602 scopus 로고    scopus 로고
    • Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
    • Carbone FR, Belz GT, Heath WR. Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity. Trends Immunol 2004; 25: 655-658.
    • (2004) Trends Immunol , vol.25 , pp. 655-658
    • Carbone, F.R.1    Belz, G.T.2    Heath, W.R.3
  • 34
    • 33745609027 scopus 로고    scopus 로고
    • Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization
    • He Y, Zhang J, Donahue C, Falo Jr LD. Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization. Immunity 2006; 24: 643-656.
    • (2006) Immunity , vol.24 , pp. 643-656
    • He, Y.1    Zhang, J.2    Donahue, C.3    Falo Jr, L.D.4
  • 35
    • 65249099085 scopus 로고    scopus 로고
    • Cross-presentation of viral and self antigens by skin-derived CD103(+) dendritic cells
    • Bedoui S, Whitney PG, Waithman J, Eidsmo L, Wakim L, Caminschi I et al. Cross-presentation of viral and self antigens by skin-derived CD103(+) dendritic cells. Nat Immunol 2009; 10: 488-495.
    • (2009) Nat Immunol , vol.10 , pp. 488-495
    • Bedoui, S.1    Whitney, P.G.2    Waithman, J.3    Eidsmo, L.4    Wakim, L.5    Caminschi, I.6
  • 36
    • 33745976440 scopus 로고    scopus 로고
    • Migratory dendritic cells: Sometimes simply ferries?
    • Randolph GJ. Migratory dendritic cells: sometimes simply ferries? Immunity 2006; 25: 15-18.
    • (2006) Immunity , vol.25 , pp. 15-18
    • Randolph, G.J.1
  • 37
    • 0027248719 scopus 로고
    • Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigenspecific T cells
    • Moll H, Fuchs H, Blank C, Rö llinghoff M. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigenspecific T cells. Eur J Immunol 1993; 23: 1595-1601.
    • (1993) Eur J Immunol , vol.23 , pp. 1595-1601
    • Moll, H.1    Fuchs, H.2    Blank, C.3    Röllinghoff, M.4
  • 38
    • 0026539390 scopus 로고
    • Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis
    • Will A, Blank C, Rö llinghoff M, Moll H. Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis. Eur J Immunol 1992; 22: 1341-1347.
    • (1992) Eur J Immunol , vol.22 , pp. 1341-1347
    • Will, A.1    Blank, C.2    Röllinghoff, M.3    Moll, H.4
  • 39
    • 3242679958 scopus 로고    scopus 로고
    • CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis
    • Ritter U, Meissner A, Scheidig C, Körner H. CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis. Eur J Immunol 2004; 34: 1542-1550.
    • (2004) Eur J Immunol , vol.34 , pp. 1542-1550
    • Ritter, U.1    Meissner, A.2    Scheidig, C.3    Körner, H.4
  • 40
    • 60549091808 scopus 로고    scopus 로고
    • Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes
    • Brewig N, Kissenpfennig A, Malissen B, Veit A, Bickert T, Fleischer B et al. Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes. J Immunol 2009; 182: 774-783.
    • (2009) J Immunol , vol.182 , pp. 774-783
    • Brewig, N.1    Kissenpfennig, A.2    Malissen, B.3    Veit, A.4    Bickert, T.5    Fleischer, B.6
  • 41
    • 0034661692 scopus 로고    scopus 로고
    • A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity
    • Belkaid Y, Mendez S, Lira R, Kadambi N, Milon G, Sacks D. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity. J Immunol 2000; 165: 969-977.
    • (2000) J Immunol , vol.165 , pp. 969-977
    • Belkaid, Y.1    Mendez, S.2    Lira, R.3    Kadambi, N.4    Milon, G.5    Sacks, D.6
  • 42
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    • Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002; 420: 502-507.
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 43
    • 39149109612 scopus 로고    scopus 로고
    • Division of labor, plasticity, and crosstalk between dendritic cell subsets
    • Pulendran B, Tang H, Denning TL. Division of labor, plasticity, and crosstalk between dendritic cell subsets. Curr Opin Immunol 2008; 20: 61-67.
    • (2008) Curr Opin Immunol , vol.20 , pp. 61-67
    • Pulendran, B.1    Tang, H.2    Denning, T.L.3
  • 44
    • 0033984930 scopus 로고    scopus 로고
    • Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    • Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 2000; 12: 71-81.
    • (2000) Immunity , vol.12 , pp. 71-81
    • Valladeau, J.1    Ravel, O.2    Dezutter-Dambuyant, C.3    Moore, K.4    Kleijmeer, M.5    Liu, Y.6
  • 45
    • 0002603988 scopus 로고
    • An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cell) in vitiligo
    • Birbeck MS, Breathnach AS, Everall JD. An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cell) in vitiligo. J Invest Dermatol 1961; 37: 51-64.
    • (1961) J Invest Dermatol , vol.37 , pp. 51-64
    • Birbeck, M.S.1    Breathnach, A.S.2    Everall, J.D.3
  • 47
    • 0037289787 scopus 로고    scopus 로고
    • Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207
    • Stoitzner P, Holzmann S, McLellan AD, Ivarsson L, Stössel H, Kapp M et al. Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. J Invest Dermatol 2003; 120: 266-274.
    • (2003) J Invest Dermatol , vol.120 , pp. 266-274
    • Stoitzner, P.1    Holzmann, S.2    McLellan, A.D.3    Ivarsson, L.4    Stössel, H.5    Kapp, M.6
  • 48
    • 0033392139 scopus 로고    scopus 로고
    • The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface
    • Valladeau J, Duvert-Frances V, Pin JJ, Dezutter-Dambuyant C, Vincent C, Massacrier C et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol 1999; 29: 2695-2704.
    • (1999) Eur J Immunol , vol.29 , pp. 2695-2704
    • Valladeau, J.1    Duvert-Frances, V.2    Pin, J.J.3    Dezutter-Dambuyant, C.4    Vincent, C.5    Massacrier, C.6
  • 50
    • 0036097245 scopus 로고    scopus 로고
    • Identification and expression of mouse Langerin (CD207) in dendritic cells
    • Takahara K, Omatsu Y, Yashima Y, Maeda Y, Tanaka S, Iyoda T et al. Identification and expression of mouse Langerin (CD207) in dendritic cells. Int Immunol 2002; 14: 433-444.
    • (2002) Int Immunol , vol.14 , pp. 433-444
    • Takahara, K.1    Omatsu, Y.2    Yashima, Y.3    Maeda, Y.4    Tanaka, S.5    Iyoda, T.6
  • 51
    • 0034899321 scopus 로고    scopus 로고
    • Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice
    • Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y et al. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol 2001; 19: 746-750.
    • (2001) Nat Biotechnol , vol.19 , pp. 746-750
    • Saito, M.1    Iwawaki, T.2    Taya, C.3    Yonekawa, H.4    Noda, M.5    Inui, Y.6
  • 52
    • 0026747170 scopus 로고
    • Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor
    • Naglich JG, Metherall JE, Russell DW, Eidels L. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 1992; 69: 1051-1061.
    • (1992) Cell , vol.69 , pp. 1051-1061
    • Naglich, J.G.1    Metherall, J.E.2    Russell, D.W.3    Eidels, L.4
  • 53
    • 0030779109 scopus 로고    scopus 로고
    • Structure-function analysis of the diphtheria toxin receptor toxin binding site by site-directed mutagenesis
    • Mitamura T, Umata T, Nakano F, Shishido Y, Toyoda T, Itai A et al. Structure-function analysis of the diphtheria toxin receptor toxin binding site by site-directed mutagenesis. J Biol Chem 1997; 272: 27084-27090.
    • (1997) J Biol Chem , vol.272 , pp. 27084-27090
    • Mitamura, T.1    Umata, T.2    Nakano, F.3    Shishido, Y.4    Toyoda, T.5    Itai, A.6
  • 54
    • 85058248273 scopus 로고    scopus 로고
    • DC ablation in mice: Promises, pitfalls, and challenges
    • Bennett CL, Clausen BE. DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol 2007; 28: 525-531.
    • (2007) Trends Immunol , vol.28 , pp. 525-531
    • Bennett, C.L.1    Clausen, B.E.2
  • 55
    • 18644375874 scopus 로고    scopus 로고
    • In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens
    • Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 2002; 17: 211-220.
    • (2002) Immunity , vol.17 , pp. 211-220
    • Jung, S.1    Unutmaz, D.2    Wong, P.3    Sano, G.4    De Los Santos, K.5    Sparwasser, T.6
  • 56
    • 22344443257 scopus 로고    scopus 로고
    • Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    • Bennett CL, van Rijn E, Jung S, Inaba K, Steinman RM, Kapsenberg ML et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 2005; 169: 569-576.
    • (2005) J Cell Biol , vol.169 , pp. 569-576
    • Bennett, C.L.1    Van Rijn, E.2    Jung, S.3    Inaba, K.4    Steinman, R.M.5    Kapsenberg, M.L.6
  • 57
    • 21144444056 scopus 로고    scopus 로고
    • Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    • Kissenpfennig A, Henri S, Dubois B, Laplace-Builhé C, Perrin P, Romani N et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 2005; 22: 643-654.
    • (2005) Immunity , vol.22 , pp. 643-654
    • Kissenpfennig, A.1    Henri, S.2    Dubois, B.3    Laplace-Builhé, C.4    Perrin, P.5    Romani, N.6
  • 58
    • 28844492624 scopus 로고    scopus 로고
    • Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    • Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005; 23: 611-620.
    • (2005) Immunity , vol.23 , pp. 611-620
    • Kaplan, D.H.1    Jenison, M.C.2    Saeland, S.3    Shlomchik, W.D.4    Shlomchik, M.J.5
  • 59
    • 21444454735 scopus 로고    scopus 로고
    • A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
    • Buch T, Heppner FL, Tertilt C, Heinen TJ, Kremer M, Wunderlich FT et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2005; 2: 419-426.
    • (2005) Nat Methods , vol.2 , pp. 419-426
    • Buch, T.1    Heppner, F.L.2    Tertilt, C.3    Heinen, T.J.4    Kremer, M.5    Wunderlich, F.T.6
  • 60
    • 33746860835 scopus 로고    scopus 로고
    • An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus
    • Brockschnieder D, Pechmann Y, Sonnenberg-Riethmacher E, Riethmacher D. An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 2006; 44: 322-327.
    • (2006) Genesis , vol.44 , pp. 322-327
    • Brockschnieder, D.1    Pechmann, Y.2    Sonnenberg-Riethmacher, E.3    Riethmacher, D.4
  • 62
  • 63
    • 34447275920 scopus 로고    scopus 로고
    • Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen
    • Caton ML, Smith-Raska MR, Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med 2007; 204: 1653-1664.
    • (2007) J Exp Med , vol.204 , pp. 1653-1664
    • Caton, M.L.1    Smith-Raska, M.R.2    Reizis, B.3
  • 64
    • 0023032287 scopus 로고
    • Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells
    • Sullivan S, Bergstresser PR, Tigelaar RE, Streilein JW. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. J Immunol 1986; 137: 2460-2467.
    • (1986) J Immunol , vol.137 , pp. 2460-2467
    • Sullivan, S.1    Bergstresser, P.R.2    Tigelaar, R.E.3    Streilein, J.W.4
  • 66
    • 37549019986 scopus 로고    scopus 로고
    • The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
    • Poulin LF, Henri S, de Bovis B, Devilard E, Kissenpfennig A, Malissen B. The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 2007; 204: 3119-3131.
    • (2007) J Exp Med , vol.204 , pp. 3119-3131
    • Poulin, L.F.1    Henri, S.2    De Bovis, B.3    Devilard, E.4    Kissenpfennig, A.5    Malissen, B.6
  • 67
    • 37549030450 scopus 로고    scopus 로고
    • Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    • Ginhoux F, Collin MP, Bogunovic M, Abel M, Leboeuf M, Helft J et al. Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J ExpMed 2007; 204: 3133-3146.
    • (2007) J ExpMed , vol.204 , pp. 3133-3146
    • Ginhoux, F.1    Collin, M.P.2    Bogunovic, M.3    Abel, M.4    Leboeuf, M.5    Helft, J.6
  • 68
    • 62549149956 scopus 로고    scopus 로고
    • Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    • Nagao K, Ginhoux F, Leitner WW, Motegi S, Bennett CL, Clausen BE et al. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci USA 2009; 106: 3312-3317.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3312-3317
    • Nagao, K.1    Ginhoux, F.2    Leitner, W.W.3    Motegi, S.4    Bennett, C.L.5    Clausen, B.E.6
  • 69
    • 76149133088 scopus 로고    scopus 로고
    • CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    • S1-6
    • Henri S, Poulin LF, Tamoutounour S, Ardouin L, Guilliams M, de Bovis B et al. CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 2010; 207: 189-206. S1-6.
    • (2010) J Exp Med , vol.207 , pp. 189-206
    • Henri, S.1    Poulin, L.F.2    Tamoutounour, S.3    Ardouin, L.4    Guilliams, M.5    De Bovis, B.6
  • 70
    • 55249092998 scopus 로고    scopus 로고
    • Insights into Langerhans cell function from Langerhans cell ablation models
    • Kaplan DH, Kissenpfennig A, Clausen BE. Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol 2008; 38: 2369-2376.
    • (2008) Eur J Immunol , vol.38 , pp. 2369-2376
    • Kaplan, D.H.1    Kissenpfennig, A.2    Clausen, B.E.3
  • 72
    • 38149085156 scopus 로고    scopus 로고
    • Langerhans cells are required for efficient presentation of topically applied hapten to T cells
    • Bennett CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol 2007; 179: 6830-6835.
    • (2007) J Immunol , vol.179 , pp. 6830-6835
    • Bennett, C.L.1    Noordegraaf, M.2    Martina, C.A.3    Clausen, B.E.4
  • 73
    • 75649090136 scopus 로고    scopus 로고
    • Langerhans cells at the interface of medicine, science, and industry
    • Stoitzner P, Stingl G, Merad M, Romani N. Langerhans cells at the interface of medicine, science, and industry. J Invest Dermatol 2010; 130: 331-335.
    • J Invest Dermatol , vol.2010 , Issue.130 , pp. 331-335
    • Stoitzner, P.1    Stingl, G.2    Merad, M.3    Romani, N.4
  • 74
    • 0031045202 scopus 로고    scopus 로고
    • High and low doses of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity
    • Bacci S, Alard P, Dai R, Nakamura T, Streilein JW. High and low doses of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity. Eur J Immunol 1997; 27: 442-448.
    • (1997) Eur J Immunol , vol.27 , pp. 442-448
    • Bacci, S.1    Alard, P.2    Dai, R.3    Nakamura, T.4    Streilein, J.W.5
  • 76
    • 0018866633 scopus 로고
    • Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB
    • Toews GB, Bergstresser PR, Streilein JW. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 1980; 124: 445-453.
    • (1980) J Immunol , vol.124 , pp. 445-453
    • Toews, G.B.1    Bergstresser, P.R.2    Streilein, J.W.3
  • 77
    • 63449108301 scopus 로고    scopus 로고
    • Constitutive ablation of dendritic cells breaks self-tolerance of CD4T cells and results in spontaneous fatal autoimmunity
    • Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009; 206: 549-559.
    • (2009) J Exp Med , vol.206 , pp. 549-559
    • Ohnmacht, C.1    Pullner, A.2    King, S.B.3    Drexler, I.4    Meier, S.5    Brocker, T.6
  • 79
    • 2442658900 scopus 로고    scopus 로고
    • Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    • Merad M, Hoffmann P, Ranheim E, Slaymaker S, Manz MG, Lira SA et al. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med 2004; 10: 510-517.
    • (2004) Nat Med , vol.10 , pp. 510-517
    • Merad, M.1    Hoffmann, P.2    Ranheim, E.3    Slaymaker, S.4    Manz, M.G.5    Lira, S.A.6
  • 80
    • 22144484148 scopus 로고    scopus 로고
    • Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation
    • Stoitzner P, Tripp CH, Douillard P, Saeland S, Romani N. Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation. J Invest Dermatol 2005; 125: 116-125.
    • (2005) J Invest Dermatol , vol.125 , pp. 116-125
    • Stoitzner, P.1    Tripp, C.H.2    Douillard, P.3    Saeland, S.4    Romani, N.5
  • 81
    • 0031022619 scopus 로고    scopus 로고
    • Sunlight and skin cancer: Another link revealed
    • Kraemer KH. Sunlight and skin cancer: another link revealed. Proc Natl Acad Sci USA 1997; 94: 11-14.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11-14
    • Kraemer, K.H.1
  • 83
    • 0020567012 scopus 로고
    • Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation
    • Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ, Streilein JW. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 1983; 158: 781-794.
    • (1983) J Exp Med , vol.158 , pp. 781-794
    • Elmets, C.A.1    Bergstresser, P.R.2    Tigelaar, R.E.3    Wood, P.J.4    Streilein, J.W.5
  • 84
    • 37249046514 scopus 로고    scopus 로고
    • 25 years of UV-induced immunosuppression mediated by T cells-from disregarded T suppressor cells to highly respected regulatory T cells
    • Schwarz T. 25 years of UV-induced immunosuppression mediated by T cells-from disregarded T suppressor cells to highly respected regulatory T cells. Photochem Photobiol 2008; 84: 10-18.
    • (2008) Photochem Photobiol , vol.84 , pp. 10-18
    • Schwarz, T.1
  • 85
    • 13244295620 scopus 로고    scopus 로고
    • Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair
    • Schwarz A, Maeda A, Kernebeck K, van Steeg H, Beissert S, Schwarz T. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 2005; 201: 173-179.
    • (2005) J Exp Med , vol.201 , pp. 173-179
    • Schwarz, A.1    Maeda, A.2    Kernebeck, K.3    Van Steeg, H.4    Beissert, S.5    Schwarz, T.6
  • 87
    • 77349115170 scopus 로고    scopus 로고
    • Epidermal Langerhans cells are not required for UV-induced immunosuppression
    • Wang L, Jameson SC, Hogquist KA. Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol 2009; 183: 5548-5553.
    • (2009) J Immunol , vol.183 , pp. 5548-5553
    • Wang, L.1    Jameson, S.C.2    Hogquist, K.A.3
  • 88
    • 0141956458 scopus 로고    scopus 로고
    • Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression
    • Kölgen W, van Steeg H, van der Horst GT, Hoeijmakers JH, van Vloten WA, de Gruijl FR et al. Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. J Invest Dermatol 2003; 121: 751-756.
    • (2003) J Invest Dermatol , vol.121 , pp. 751-756
    • Kölgen, W.1    Van Steeg, H.2    Van Der Horst, G.T.3    Hoeijmakers, J.H.4    Van Vloten, W.A.5    De Gruijl, F.R.6
  • 89
    • 33846225254 scopus 로고    scopus 로고
    • Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells
    • Schwarz A, Maeda A, Schwarz T. Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells. J Immunol 2007; 178: 877-886.
    • (2007) J Immunol , vol.178 , pp. 877-886
    • Schwarz, A.1    Maeda, A.2    Schwarz, T.3
  • 90
    • 0035801477 scopus 로고    scopus 로고
    • Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity
    • Mehling A, Loser K, Varga G, Metze D, Luger TA, Schwarz T et al. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med 2001; 194: 615-628.
    • (2001) J Exp Med , vol.194 , pp. 615-628
    • Mehling, A.1    Loser, K.2    Varga, G.3    Metze, D.4    Luger, T.A.5    Schwarz, T.6
  • 91
    • 0030702821 scopus 로고    scopus 로고
    • Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis
    • Seery JP, Carroll JM, Cattell V, Watt FM. Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis. J Exp Med 1997; 186: 1451-1459.
    • (1997) J Exp Med , vol.186 , pp. 1451-1459
    • Seery, J.P.1    Carroll, J.M.2    Cattell, V.3    Watt, F.M.4
  • 93
    • 67349266988 scopus 로고    scopus 로고
    • UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo
    • Glaser R, Navid F, Schuller W, Jantschitsch C, Harder J, Schröder JM et al. UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo. J Allergy Clin Immunol 2009; 123: 1117-1123.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1117-1123
    • Glaser, R.1    Navid, F.2    Schuller, W.3    Jantschitsch, C.4    Harder, J.5    Schröder, J.M.6
  • 94
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90: 770-774.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3    Geiser, A.4    Lyght, M.5    Flanders, K.C.6
  • 95
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992; 359: 693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6
  • 96
    • 0037100520 scopus 로고    scopus 로고
    • Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
    • Leveen P, Larsson J, Ehinger M, Cilio CM, Sundler M, Sjöstrand LJ et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood 2002; 100: 560-568.
    • (2002) Blood , vol.100 , pp. 560-568
    • Leveen, P.1    Larsson, J.2    Ehinger, M.3    Cilio, C.M.4    Sundler, M.5    Sjöstrand, L.J.6
  • 97
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • Marie JC, Liggitt D, Rudensky AY. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 2006; 25: 441-454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 98
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000; 12: 171-181.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 100
    • 21244489290 scopus 로고    scopus 로고
    • Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling
    • Karlsson G, Liu Y, Larsson J, Goumans MJ, Lee JS, Thorgeirsson SS et al. Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling. Physiol Genomics 2005; 21: 396-403.
    • (2005) Physiol Genomics , vol.21 , pp. 396-403
    • Karlsson, G.1    Liu, Y.2    Larsson, J.3    Goumans, M.J.4    Lee, J.S.5    Thorgeirsson, S.S.6
  • 101
    • 0033561648 scopus 로고    scopus 로고
    • TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells
    • Geissmann F, Revy P, Regnault A, Lepelletier Y, Dy M, Brousse N et al. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol 1999; 162: 4567-4575.
    • (1999) J Immunol , vol.162 , pp. 4567-4575
    • Geissmann, F.1    Revy, P.2    Regnault, A.3    Lepelletier, Y.4    Dy, M.5    Brousse, N.6
  • 102
    • 61449211195 scopus 로고    scopus 로고
    • TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation
    • Ohtani T, Mizuashi M, Nakagawa S, Sasaki Y, Fujimura T, Okuyama R et al. TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation. Immunology 2009; 126: 485-499.
    • (2009) Immunology , vol.126 , pp. 485-499
    • Ohtani, T.1    Mizuashi, M.2    Nakagawa, S.3    Sasaki, Y.4    Fujimura, T.5    Okuyama, R.6
  • 103
    • 77949893984 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells
    • Torres-Aguilar H, Aguilar-Ruiz SR, Gonzalez-Perez G, Mungúa R, Bajaña S, Meraz-Ŕos MA et al. Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells. J Immunol 2010; 184: 1765-1775.
    • (2010) J Immunol , vol.184 , pp. 1765-1775
    • Torres-Aguilar, H.1    Aguilar-Ruiz, S.R.2    Gonzalez-Perez, G.3    Mungúa, R.4    Bajaña, S.5    Meraz-Ŕos, M.A.6
  • 105
    • 0842321793 scopus 로고    scopus 로고
    • Cutting edge: In vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis
    • Faunce DE, Terajewicz A, Stein-Streilein J. Cutting edge: in vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis. J Immunol 2004; 172: 1991-1995.
    • (2004) J Immunol , vol.172 , pp. 1991-1995
    • Faunce, D.E.1    Terajewicz, A.2    Stein-Streilein, J.3
  • 106
    • 0030456368 scopus 로고    scopus 로고
    • A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
    • Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J ExpMed 1996; 184: 2417-2422.
    • (1996) J ExpMed , vol.184 , pp. 2417-2422
    • Borkowski, T.A.1    Letterio, J.J.2    Farr, A.G.3    Udey, M.C.4
  • 107
    • 0030612475 scopus 로고    scopus 로고
    • A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice
    • Borkowski TA, Letterio JJ, Mackall CL, Saitoh A, Wang XJ, Roop DR et al. A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice. J Clin Invest 1997; 100: 575-581.
    • (1997) J Clin Invest , vol.100 , pp. 575-581
    • Borkowski, T.A.1    Letterio, J.J.2    MacKall, C.L.3    Saitoh, A.4    Wang, X.J.5    Roop, D.R.6
  • 108
    • 0037386339 scopus 로고    scopus 로고
    • Transcriptional profiling identifies Id2 function in dendritic cell development
    • Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 2003; 4: 380-386.
    • (2003) Nat Immunol , vol.4 , pp. 380-386
    • Hacker, C.1    Kirsch, R.D.2    Ju, X.S.3    Hieronymus, T.4    Gust, T.C.5    Kuhl, C.6
  • 109
    • 12144285752 scopus 로고    scopus 로고
    • Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation
    • Fainaru O, Woolf E, Lotem J, Yarmus M, Brenner O, Goldenberg D et al. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J 2004; 23: 969-979.
    • (2004) EMBO J , vol.23 , pp. 969-979
    • Fainaru, O.1    Woolf, E.2    Lotem, J.3    Yarmus, M.4    Brenner, O.5    Goldenberg, D.6
  • 110
    • 0035670921 scopus 로고    scopus 로고
    • Appearance of Langerhans cells in the epidermis of Tgfb1 SCID mice: Paracrine and autocrine effects of transforming growth factor-beta 1 and -beta 2
    • Thomas RM, Belsito DV, Huang C, Chen LZ, Ormsby I, Simmons WJ et al. Appearance of Langerhans cells in the epidermis of Tgfb1 SCID mice: paracrine and autocrine effects of transforming growth factor-beta 1 and -beta 2. J Invest Dermatol 2001; 117: 1574-1580.
    • (2001) J Invest Dermatol , vol.117 , pp. 1574-1580
    • Thomas, R.M.1    Belsito, D.V.2    Huang, C.3    Chen, L.Z.4    Ormsby, I.5    Simmons, W.J.6
  • 113
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, Lohler J, Rennick D, Rajewsky K, Mü ller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 114
    • 0032536530 scopus 로고    scopus 로고
    • The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
    • Spencer SD, Di Marco F, Hooley J, Pitts-Meek S, Bauer M, Ryan AM et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med 1998; 187: 571-578.
    • (1998) J Exp Med , vol.187 , pp. 571-578
    • Spencer, S.D.1    Di Marco, F.2    Hooley, J.3    Pitts-Meek, S.4    Bauer, M.5    Ryan, A.M.6
  • 115
    • 9244237038 scopus 로고    scopus 로고
    • T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    • Roers A, Siewe L, Strittmatter E, Deckert M, Schlü ter D, Stenzel W et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med 2004; 200: 1289-1297.
    • (2004) J Exp Med , vol.200 , pp. 1289-1297
    • Roers, A.1    Siewe, L.2    Strittmatter, E.3    Deckert, M.4    Schlüter, D.5    Stenzel, W.6
  • 116
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008; 28: 546-558.
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3    Fontenot, J.4    Castelli, L.5    Ye, X.6
  • 117
    • 33845574337 scopus 로고    scopus 로고
    • Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
    • Siewe L, Bollati-Fogolin M, Wickenhauser C, Krieg T, Mü ller W, Roers A. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol 2006; 36: 3248-3255.
    • (2006) Eur J Immunol , vol.36 , pp. 3248-3255
    • Siewe, L.1    Bollati-Fogolin, M.2    Wickenhauser, C.3    Krieg, T.4    Müller, W.5    Roers, A.6
  • 118
    • 75149114226 scopus 로고    scopus 로고
    • Monocytes/ macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    • Pils MC, Pisano F, Fasnacht N, Heinrich JM, Groebe L, Schippers A et al. Monocytes/ macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol 2010; 40: 443-448.
    • (2010) Eur J Immunol , vol.40 , pp. 443-448
    • Pils, M.C.1    Pisano, F.2    Fasnacht, N.3    Heinrich, J.M.4    Groebe, L.5    Schippers, A.6
  • 119
    • 0033105695 scopus 로고    scopus 로고
    • Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells
    • Steinbrink K, Jonuleit H, Mü ller G, Schuler G, Knop J, Enk AH. Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells. Blood 1999; 93: 1634-1642.
    • (1999) Blood , vol.93 , pp. 1634-1642
    • Steinbrink, K.1    Jonuleit, H.2    Müller, G.3    Schuler, G.4    Knop, J.5    Enk, A.H.6
  • 120
    • 0036430017 scopus 로고    scopus 로고
    • Interleukin-10- treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo
    • Mü ller G, Mü ller A, Tü ting T, Steinbrink K, Saloga J, Szalma C et al. Interleukin-10- treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo. J Invest Dermatol 2002; 119: 836-841.
    • (2002) J Invest Dermatol , vol.119 , pp. 836-841
    • Müller, G.1    Müller, A.2    Tüting, T.3    Steinbrink, K.4    Saloga, J.5    Szalma, C.6
  • 121
    • 34548808554 scopus 로고    scopus 로고
    • IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease
    • Perona-Wright G, Anderton SM, Howie SE, Gray D. IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease. Int Immunol 2007; 19: 1123-1134.
    • (2007) Int Immunol , vol.19 , pp. 1123-1134
    • Perona-Wright, G.1    Anderton, S.M.2    Howie, S.E.3    Gray, D.4
  • 122
    • 33750339165 scopus 로고    scopus 로고
    • Alternatively activated' dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig
    • Lan YY, Wang Z, Raimondi G, Wu W, Colvin BL, de Creus A et al. 'Alternatively activated' dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol 2006; 177: 5868-5877.
    • (2006) J Immunol , vol.177 , pp. 5868-5877
    • Lan, Y.Y.1    Wang, Z.2    Raimondi, G.3    Wu, W.4    Colvin, B.L.5    De Creus, A.6
  • 123
    • 0029035110 scopus 로고
    • Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses
    • Berg DJ, Leach MW, Kühn R, Rajewsky K, Mü ller W, Davidson NJ et al. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 1995; 182: 99-108.
    • (1995) J Exp Med , vol.182 , pp. 99-108
    • Berg, D.J.1    Leach, M.W.2    Kühn, R.3    Rajewsky, K.4    Mü Ller, W.5    Davidson, N.J.6
  • 124
    • 34548757393 scopus 로고    scopus 로고
    • Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    • Grimbaldeston MA, Nakae S, Kalesnikoff J, Tsai M, Galli SJ. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 2007; 8: 1095-1104.
    • (2007) Nat Immunol , vol.8 , pp. 1095-1104
    • Grimbaldeston, M.A.1    Nakae, S.2    Kalesnikoff, J.3    Tsai, M.4    Galli, S.J.5
  • 125
    • 77349125610 scopus 로고    scopus 로고
    • Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10
    • Igyarto BZ, Jenison MC, Dudda JC, Roers A, Mü ller W, Koni PA et al. Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol 2009; 183: 5085-5093.
    • (2009) J Immunol , vol.183 , pp. 5085-5093
    • Igyarto, B.Z.1    Jenison, M.C.2    Dudda, J.C.3    Roers, A.4    Mü Ller, W.5    Koni, P.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.